Glutamatergic system components as potential biomarkers and therapeutic targets in cancer in non-neural organs

Autor: Ana Cristina García-Gaytán, Andy Hernández-Abrego, Mauricio Díaz-Muñoz, Isabel Méndez

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Glutamate is one of the most abundant amino acids in the blood. Besides its role as a neurotransmitter in the brain, it is a key substrate in several metabolic pathways and a primary messenger that acts through its receptors outside the central nervo

Externí odkaz: https://doaj.org/article/305346646e4e484d8a74a30bd2229422

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Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures

Autor: Paul B. Bernard, Anna M. Castano, Heather O'Leary, Kameron Simpson, Michael D. Browning, Tim A. Benke

Publikováno v: Neurobiology of Disease, Vol 59, Iss , Pp 1-17 (2013)

Outside of Fragile X syndrome (FXS), the role of Fragile-X Mental Retardation Protein (FMRP) in mediating neuropsychological abnormalities is not clear. FMRP, p70-S6 kinase (S6K) and protein phosphatase 2A (PP2A) are thought to cooperate as a dynamic

Externí odkaz: https://doaj.org/article/4a059921a781407b98ebd9b84e3fe38e

The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells

Autor: Melina A. Agosto, Theodore G. Wensel, Nitin Kumar, Abiodun Adefola R. Adeosun

Publikováno v: The Journal of Biological Chemistry

Signals from retinal photoreceptors are processed in two parallel channels - the ON channel responds to light increments, while the OFF channel responds to light decrements. The ON pathway is mediated by ON type bipolar cells (BCs), which receive glu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0db22b29f6ce21978ada0b80745ba51
https://doi.org/10.1016/j.jbc.2021.101418

Fragile X syndrome: Current insight

Autor: Srinivasn Muthuswamy, Sarita Agarwal, Deepika Delsa Dean

Publikováno v: Egyptian Journal of Medical Human Genetics; Vol 17, No 4 (2016); 303-309
Egyptian Journal of Medical Human Genetics, Vol 17, Iss 4, Pp 303-309 (2016)

Fragile X syndrome (FXS) is a multigenerational disorder having massive adverse effect not only on the individuals but also on their families. It is the most common type of intellectual disability after Down’s syndrome. Over two decades have passed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2ac8318f8deaa292029ac369866143
https://doi.org/10.1016/j.ejmhg.2016.01.005