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Another level of complex-ity: The role of metabolic channeling and metabolons in plant terpenoid metabolism

Autor: Michael Gutensohn, Erin Hartzell, Natalia Dudareva

Publikováno v: Frontiers in Plant Science, Vol 13 (2022)

Terpenoids constitute one of the largest and most diverse classes of plant metabolites. While some terpenoids are involved in essential plant processes such as photosynthesis, respiration, growth, and development, others are specialized metabolites p

Externí odkaz: https://doaj.org/article/5a7cf497d50247de84f33f939f523b16

In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium

Autor: Timothy D. Cummins, Teresa Cassel, William L. Dean, Bradford G. Hill, Michael L. Merchant, Teresa W.-M. Fan, Yuting Zheng, Pawel Lorkiewicz, Timothy N. Audam, Kyle L Fulghum

Publikováno v: Journal of molecular and cellular cardiology

Glucose metabolism comprises numerous amphibolic metabolites that provide precursors for not only the synthesis of cellular building blocks but also for ATP production. In this study, we tested how phosphofructokinase-1 (PFK1) activity controls the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfab0d6e4b4bb24d1f180727cf9a373e
http://europepmc.org/articles/PMC8766935

Detecting Protein Communities in Native Cell Extracts by Machine Learning: A Structural Biologist’s Perspective

Autor: Kyrilis, Fotis L., Belapure, Jaydeep, Kastritis, Panagiotis L.

Publikováno v: Frontiers in Molecular Biosciences

Native cell extracts hold great promise for understanding the molecular structure of ordered biological systems at high resolution. This is because higher-order biomolecular interactions, dubbed as protein communities, may be retained in their (near-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928a7a54e638c02d4f47fefb2d60ceb6
http://europepmc.org/articles/PMC8082361

Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent

Autor: Birger Lindberg Møller, Damian P. Drew, Tomas Laursen, Mohammed Saddik Motawia, Ketil Mathiasen Viborg, Krutika Bavishi, Camilla Knudsen, Henrik Toft Simonsen

Publikováno v: Knudsen, C, Bavishi, K, Viborg, K M, Drew, D P, Simonsen, H T, Motawia, M S, Møller, B L & Laursen, T 2020, ' Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent ', Phytochemistry, vol. 170, 112214 . https://doi.org/10.1016/j.phytochem.2019.112214

In recent years, ionic liquids and deep eutectic solvents (DESs) have gained increasing attention due to their ability to extract and solubilize metabolites and biopolymers in quantities far beyond their solubility in oil and water. The hypothesis th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fe7c7054f6c2de460cf2fcce139eff
https://orbit.dtu.dk/en/publications/fe44f4b3-6fd0-469c-bab7-ac4c93ef35a5