Exploring copper metabolism-induced cell death in gastric cancer: a single-cell RNA sequencing study and prognostic model development

Autor: Yi Chen, Yunmei Liao, Lang Huang, Zhibin Luo

Publikováno v: Discover Oncology, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Background Gastric cancer (GC) is the third leading cause of cancer-related deaths globally. Despite advancements in treatment, the overall 5-year survival rate remains below 30%, particularly in advanced stages. Copper metabolism, vital for

Externí odkaz: https://doaj.org/article/b2b0e146d2644348aa2cd245e0391117

Investigating the T cell Intrinsic Regulatory Role of VISTA in Anti-Tumor Immunity

Autor: Gilmour, Cassandra

The effector function of cytotoxic lymphocytes (CTLs) is precisely managed through TCR MHC engagement, co-stimulatory axis as well as co-inhibitory pathways. Due to the deprived environment in a tumor and persistent antigen stimulation, CTLs lose the

Externí odkaz: http://rave.ohiolink.edu/etdc/view?acc_num=case1681724746785326

Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments

Autor: Hristo Varbanov, Shaobo Jia, Gaga Kochlamazashvili, Subhrajit Bhattacharya, Manal Ali Buabeid, Mohamed El Tabbal, Hussam Hayani, Stoyan Stoyanov, Weilun Sun, Hauke Thiesler, Iris Röckle, Herbert Hildebrandt, Oleg Senkov, Vishnu Suppiramaniam, Rita Gerardy-Schahn, Alexander Dityatev

Publikováno v: Neurobiology of disease 180, 106079 (2023). doi:10.1016/j.nbd.2023.106079

Dysregulated cortical expression of the neural cell adhesion molecule (NCAM) and deficits of its associated polysialic acid (polySia) have been found in Alzheimer's disease and schizophrenia. However, the functional role of polySia in cortical synapt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f354e170b2cd5947183efd880fd341c1
https://pub.dzne.de/record/257594

REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION

Autor: N. G. Plekhova, I. N. Lyapun, L. M. Somova, G. G. Kompanets, I. N. Smirnov

Publikováno v: Acta Biomedica Scientifica, Vol 0, Iss 3(2), Pp 297-300 (2012)

The paper presents evidence that the susceptibility of monocyte-derived cells to the Hantaviral infection increases when they reach the final stage of differentiation. In view of the phylogenetic homogeneity of these cells, the data obtained in the s

Externí odkaz: https://doaj.org/article/472fa3758da247bf8932a9915c8d0a13

Alterations in Blood Monocyte Functions in Parkinson's Disease

Autor: Holger Jon Møller, Claudia Schulte, Daniela Berg, Daniel E. Otzen, Kalpana Shrivastava, Sara K. Nissen, Walter Maetzler, David Goldeck, Marina Romero-Ramos

Publikováno v: Nissen, S K, Shrivastava, K, Schulte, C, Otzen, D E, Goldeck, D, Berg, D, Møller, H J, Maetzler, W & Romero-Ramos, M 2019, ' Alterations in Blood Monocyte Functions in Parkinson's Disease ', Movement Disorders, vol. 34, no. 11, pp. 1711-1721 . https://doi.org/10.1002/mds.27815
Movement disorders 34(11), 1711-1721 (2019). doi:10.1002/mds.27815

BACKGROUND: PD is a multisystem disease where both central and peripheral nervous systems are affected. This systemic involvement also includes the immune response in PD, which implicates not only microglia in the brain, but also peripheral immune ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3472c893711e71c8276085e8e54ed7
https://doi.org/10.1002/mds.27815