Zobrazeno 1 - 10
of 130
pro vyhledávání: '"metabolism [alpha-Synuclein]"'
Autor:
Mary Xylaki, Isabel Paiva, Mohammed Al-Azzani, Ellen Gerhardt, Gaurav Jain, Md Rezaul Islam, Eftychia Vasili, Zinah Wassouf, Julia M. Schulze-Hentrich, André Fischer, Tiago Fleming Outeiro
Publikováno v:
Journal of Parkinson's Disease : JPD
Journal of Parkinson's Disease 13(2), 179-196 (2023). doi:10.3233/JPD-225055
Journal of Parkinson's Disease 13(2), 179-196 (2023). doi:10.3233/JPD-225055
Background:Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise is observed in synucleinopathies parallel to aSyn aggregation and is accompanied by transcript deregulation.Objective:We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179995a601cf57d2d0eab04219b18be8
https://doi.org/10.3233/jpd-225055
https://doi.org/10.3233/jpd-225055
Autor:
Manoj Kumar, Manasa P Srikanth, Michela Deleidi, Penelope J Hallett, Ole Isacson, Ricardo A Feldman
Publikováno v:
Human molecular genetics 32(11), 1888-1900 (2023). doi:10.1093/hmg/ddad025
Bi-allelic mutations in GBA1, the gene that encodes β-glucocerebrosidase (GCase), cause Gaucher disease (GD), whereas mono-allelic mutations do not cause overt pathology. Yet mono- or bi-allelic GBA1 mutations are the highest known risk factor for P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e623d80d2d569f3311782fe53a2d787
https://doi.org/10.1093/hmg/ddad025
https://doi.org/10.1093/hmg/ddad025
Autor:
Tae-Kyung Kim, Eun-Jin Bae, Byung Chul Jung, Minsun Choi, Soo Jean Shin, Sung Jun Park, Jeong Tae Kim, Min Kyo Jung, Ayse Ulusoy, Mi-Young Song, Jun Sung Lee, He-Jin Lee, Donato A. Di Monte, Seung-Jae Lee
Publikováno v:
Experimental & molecular medicine 54(12), 2148-2161 (2022). doi:10.1038/s12276-022-00895-w
The clinical progression of neurodegenerative diseases correlates with the spread of proteinopathy in the brain. The current understanding of the mechanism of proteinopathy spread is far from complete. Here, we propose that inflammation is fundamenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e379b9c198ff4f5969aaf652911957
https://doi.org/10.1038/s12276-022-00895-w
https://doi.org/10.1038/s12276-022-00895-w
Autor:
Ullrich Wüllner, Per Borghammer, Chi-un Choe, Ilona Csoti, Björn Falkenburger, Thomas Gasser, Paul Lingor, Peter Riederer
Publikováno v:
Wüllner, U, Borghammer, P, Choe, C-U, Csoti, I, Falkenburger, B, Gasser, T, Lingor, P & Riederer, P 2023, ' The heterogeneity of Parkinson's disease ', Journal of neural transmission (Vienna, Austria : 1996), vol. 130, no. 6, pp. 827-838 . https://doi.org/10.1007/s00702-023-02635-4
Journal of neural transmission 130(6), 827-838 (2023). doi:10.1007/s00702-023-02635-4
Journal of neural transmission 130(6), 827-838 (2023). doi:10.1007/s00702-023-02635-4
The heterogeneity of Parkinson’s disease (PD), i.e. the various clinical phenotypes, pathological findings, genetic predispositions and probably also the various implicated pathophysiological pathways pose a major challenge for future research proj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b19787179daf693469a3fce56cf597
https://pure.au.dk/portal/da/publications/the-heterogeneity-of-parkinsons-disease(2c2a9eb1-19a4-4783-bf97-902f68603c22).html
https://pure.au.dk/portal/da/publications/the-heterogeneity-of-parkinsons-disease(2c2a9eb1-19a4-4783-bf97-902f68603c22).html
Autor:
Alexander Kilzheimer, Thomas Hentrich, Carola Rotermund, Philipp J Kahle, Julia M Schulze-Hentrich
Publikováno v:
Human molecular genetics 32(3), 450-461 (2023). doi:10.1093/hmg/ddac205
Nutritional influences have been discussed as potential modulators of Parkinson’s disease (PD) pathology through various epidemiological and physiological studies. In animal models, a high-fat diet (HFD) with greater intake of lipid-derived calorie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1796898c93b59fc865d9cb30511ebb
https://doi.org/10.1093/hmg/ddac205
https://doi.org/10.1093/hmg/ddac205
Autor:
Clive N. Svendsen, Helwig M, Nigel T. Maidment, Iris Lindberg, Yucer Nur, Zhan Shu, Di Monte D, Hoa A. Lam, Laperle Alexander
Publikováno v:
Journal of Parkinson's Disease 12(5), 1463-1478 (2022). doi:10.3233/JPD-213053
J Parkinsons Dis
J Parkinsons Dis
Parkinson’s disease is a devastating motor disorder involving the aberrant aggregation of the synaptic protein synuclein (aSyn) and degeneration of the nigrostriatal dopaminergic tract. We previously showed that proSAAS, a small secreted chaperone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cd3ba9f0dfbd58bcf8b93d3bd27c1d
https://doi.org/10.3233/jpd-213053
https://doi.org/10.3233/jpd-213053
Autor:
Rita Rosado-Ramos, Gonçalo M. Poças, Daniela Marques, Alexandre Foito, David M. Sevillano, Mafalda Lopes-da-Silva, Luís G. Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C. Seabra, César S. Mendes, Tiago Fleming Outeiro, Pedro M. Domingos, Cláudia N. Santos
Publikováno v:
Nature Communications 14(1), 1918 (2023). doi:10.1038/s41467-023-37561-2
Nature Communications, 14(1)
Nature Communications
Nature Communications, 14(1)
Nature Communications
Parkinson’s Disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide for which there are only symptomatic therapies. Small molecules able to target key pathological processes in PD have emerged as interesting optio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1731e38b02ddfac125b2eebd2f0dce45
https://hdl.handle.net/10362/151939
https://hdl.handle.net/10362/151939
Autor:
Matthias Schmitz, Niccolò Candelise, Sezgi Canaslan, Hermann C. Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann, Inga Zerr
Publikováno v:
Translational neurodegeneration 12(1), 12 (2023). doi:10.1186/s40035-023-00342-4
α-Synucleinopathies, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-synuclein (αSyn), referred to as Lew
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4c5cc481b8016769c70689b2aaa440
https://doi.org/10.1186/s40035-023-00342-4
https://doi.org/10.1186/s40035-023-00342-4
Autor:
Michael Klinkenberg, Michael Helwig, Rita Pinto-Costa, Angela Rollar, Raffaella Rusconi, Donato A. Di Monte, Ayse Ulusoy
Publikováno v:
Cells
Volume 12
Issue 4
Pages: 569
Cells 12(4), 569 (2023). doi:10.3390/cells12040569 special issue: "Alpha-Synuclein Pathology in Human Diseases"
Volume 12
Issue 4
Pages: 569
Cells 12(4), 569 (2023). doi:10.3390/cells12040569 special issue: "Alpha-Synuclein Pathology in Human Diseases"
Neuron-to-neuron transfer of pathogenic α-synuclein species is a mechanism of likely relevance to Parkinson’s disease development. Experimentally, interneuronal α-synuclein spreading from the low brainstem toward higher brain regions can be repro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b0d02eb8217db841e4c6f0c5210f01
Autor:
Pascale Baden, Maria Jose Perez, Hariam Raji, Federico Bertoli, Stefanie Kalb, María Illescas, Fokion Spanos, Claudio Giuliano, Alessandra Maria Calogero, Marvin Oldrati, Hannah Hebestreit, Graziella Cappelletti, Kathrin Brockmann, Thomas Gasser, Anthony H. V. Schapira, Cristina Ugalde, Michela Deleidi
Publikováno v:
Nature Communications 14(1), 1930 (2023). doi:10.1038/s41467-023-37454-4
Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher’s disease, are the most frequent genetic risk factor for Parkinson’s disease (PD). Here, we employ global proteomic and single-cell genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27055f5aa48d03d5dd4db093bb00cd70