Výsledky vyhledávání - "metabolism [Zinc]"

The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway

Autor: Giovanni Morrone, Fabrizio Bianchi, Bruna Codispoti, Enrico De Smaele, Heather M. Bond, Valeria Lucchino, Pietro Zoppoli, Annamaria Aloisio, Valentina Melocchi, Stefania Scicchitano, Emanuela Chiarella, Ylenia Montalcini, Marco Giordano, Maria Mesuraca

Publikováno v: Cell Death and Disease, Vol 10, Iss 10, Pp 1-16 (2019)
Cell Death & Disease
Cell death & disease 10(10), 715 (2019). doi:10.1038/s41419-019-1946-x

ZNF521 is a transcription co-factor with recognized regulatory functions in haematopoietic, osteo-adipogenic and neural progenitor cells. Among its diverse activities, ZNF521 has been implicated in the regulation of medulloblastoma (MB) cells, where

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20cd354fb1d1cac69c0b4dd53e2a6f3
http://link.springer.com/article/10.1038/s41419-019-1946-x

Zobrazit plný text záznamu

The Hippo pathway kinases LATS1 and 2 attenuate cellular responses to heavy metals through phosphorylating MTF1

Autor: Han Han, Hiroki J. Nakaoka, Line Hofmann, Jeff Jiajing Zhou, Clinton Yu, Lisha Zeng, Junyu Nan, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Ruxi Qi, Lee Bardwell, Dmitry A. Fishman, Ken W. Y. Cho, Lan Huang, Ray Luo, Rahul Warrior, Wenqi Wang

Publikováno v: Nat Cell Biol
Nature cell biology, vol 24, iss 1

Heavy metals are both integral parts of cells and environmental toxicants, and their deregulation is associated with severe cellular dysfunction and various diseases. Here we show that the Hippo pathway plays a critical role in regulating heavy metal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc72fa5595c58c2af5bb74b636342fb0
https://europepmc.org/articles/PMC9022944/

Zobrazit plný text záznamu

S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis

Autor: Simone Hagmeyer, Aisling M. Ross, Joerg Feldmann, Cláudio M. Gomes, Martina Bodria, Eleonora Daini, Joana S. Cristóvão, Andrea Raab, Chiara A. De Benedictis, Tobias M. Boeckers, Michele Zoli, Andreas M. Grabrucker, Antonietta Vilella

Publikováno v: Translational Psychiatry 11(1), 562 (2021). doi:10.1038/s41398-021-01694-z
Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)

Autism Spectrum Disorders (ASD) are caused by a combination of genetic predisposition and nongenetic factors. Among the nongenetic factors, maternal immune system activation and zinc deficiency have been proposed. Intriguingly, as a genetic factor, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485d1d41853c0162abf6ade98f022516
https://doi.org/10.1038/s41398-021-01694-z

Zobrazit plný text záznamu

Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength

Autor: Stefan Kindler, Charlotte J. Thynne, Craig C. Garner, Kevin Lee, Johanna M. Montgomery, Claudia Schob, Magali H. Arons, Sally A. Kim

Publikováno v: The journal of neuroscience 36(35), 9124-9134 (2016). doi:10.1523/JNEUROSCI.0116-16.2016

Shank3 is a multidomain scaffold protein localized to the postsynaptic density of excitatory synapses. Functional studies in vivo and in vitro support the concept that Shank3 is critical for synaptic plasticity and the trans-synaptic coupling between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1aad45aa2a339038bd9f0a42ce5e83d
https://doi.org/10.1523/jneurosci.0116-16.2016

Zobrazit plný text záznamu

The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance

Autor: Bianca Schrul, Dönem Avci, Oliver Schilling, Maya Schuldiner, Akio Fukumori, Elisabeth Kremmer, Marius K. Lemberg, Chia-yi Chen, Michal Breker, Harald Steiner, Martin L. Biniossek, Idan Frumkin, Shai Fuchs

Publikováno v: Mol. Cell 56, 630-640 (2014)
Molecular cell 56(5), 630-640 (2014). doi:10.1016/j.molcel.2014.10.012

Summary Proteolysis by aspartyl intramembrane proteases such as presenilin and signal peptide peptidase (SPP) underlies many cellular processes in health and disease. Saccharomyces cerevisiae encodes a homolog that we named yeast presenilin fold 1 (Y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66714995f0d6599f2e25ab6d2987cd3

Zobrazit plný text záznamu

Evaluating environmental and social influences on iron and zinc status of pregnant subsistence farmers in two geographically contrasting regions of Southern Malawi

Autor: Jeanie Rankin, Chris Robertson, Maria Pollard, Natalie Dickinson, Andrew Hursthouse, Kenneth Maleta

Publikováno v: Sci Total Environ
Sci Total Environ, 2014, 500-501, pp.199-210. ⟨10.1016/j.scitotenv.2014.08.087⟩

Dickinson, N Rankin, J Pollard, M Maleta, K Robertson, C Hursthouse, A eng NE/E008313/1/Medical Research Council/United Kingdom Research Support, Non-U.S. Gov't Netherlands 2014/09/15 06:00 Sci Total Environ. 2014 Dec 1;500-501:199-210. doi: 10.1016/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563b43ff855e46b0a041dff918a56958
https://doi.org/10.1016/j.scitotenv.2014.08.087

Zobrazit plný text záznamu

The First Structure of Dipeptidyl-peptidase III Provides Insight into the Catalytic Mechanism and Mode of Substrate Binding

Autor: Nina Jajčanin-Jozić, Pravas Kumar Baral, Karl Gruber, Peter Macheroux, Sigrid Deller, Marija Abramić

Publikováno v: The journal of biological chemistry 283, 22316-22324 (2008). doi:10.1074/jbc.M803522200

Dipeptidyl-peptidases III (DPP III) are zinc-dependent enzymes that specifically cleave the first two amino acids from the N terminus of different length peptides. In mammals, DPP III is associated with important physiological functions and is a pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364a3f33841f5786180c6d749faf8423
https://doi.org/10.1074/jbc.m803522200

Zobrazit plný text záznamu

Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma

Autor: Eva Schulze Heuling, Marc Soeren Schmidt, Matthias Endres, Arend Koch, Christoph Harms, Philipp Euskirchen, Christoph Dieterich, Marcus Czabanka, Sverre Mørk, Norman Zerbe, Meron Maricos, Ulrike Grittner, Eric Kadikowski, Felix Knab, Josefine Radke, Hrvoje Miletic

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0185376 (2017)
PLOS ONE 12(9), e0185376 (2017). doi:10.1371/journal.pone.0185376

The transcription factor ZEB1 has gained attention in tumor biology of epithelial cancers because of its function in epithelial-mesenchymal transition, DNA repair, stem cell biology and tumor-induced immunosuppression, but its role in gliomas with re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d0dfa93a58433da67b8cb05d9cd9c5
https://doi.org/10.1371/journal.pone.0185376

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání