Zobrazeno 1 - 8
of 8
pro vyhledávání: '"metabolism [Synaptosomes]"'
Autor:
Thomas Klockgether, Teodora Stella Wijasa, Stephanie Schwartz, Volkmar Gieselmann, Michael T. Heneka, Frederic Brosseron, Francesco Santarelli, Marc Sylvester, Nahal Brocke-Ahmadinejad
Publikováno v:
Journal of neurochemistry 152(6), 710-726 (2019). doi:10.1111/jnc.14870
Increasing evidence suggests that both synaptic loss and neuroinflammation constitute early pathologic hallmarks of Alzheimer's disease. A downstream event during inflammatory activation of microglia and astrocytes is the induction of nitric oxide sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7d50969e515a236ac600ac26c5a0ed
https://doi.org/10.1111/jnc.14870
https://doi.org/10.1111/jnc.14870
Autor:
Ivan Silbern, Henning Urlaub, Reinhard Jahn, Kuan-Ting Pan, Stefan Bonn, Maksims Fiosins, Silvio O. Rizzoli, Eugenio F. Fornasiero
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061
Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming action potential, voltage-gated calcium channels open, resulting in the influx of calcium ions that trigge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d93635b9e859a1023882c0903a6342
https://pubmed.ncbi.nlm.nih.gov/33582301
https://pubmed.ncbi.nlm.nih.gov/33582301
Autor:
Georg Köhr, Dušica Briševac, Dan Du, Ralf Scholz, Mohammad Nael Elagabani, Hans-Christian Kornau
Publikováno v:
Journal of neurochemistry 157(3), 666-683 (2021). doi:10.1111/jnc.15230
Journal of Neurochemistry : official journal of the International Society for Neurochemistry
Journal of Neurochemistry : official journal of the International Society for Neurochemistry
Fragile X syndrome (FXS), the most common inherited cause of intellectual disability, results from silencing of the fragile X mental retardation gene 1 (FMR1). The analyses of FXS patients’ brain autopsies revealed an increased density of immature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7c2faee993ea2120f6f513675e9a3e
https://pubmed.ncbi.nlm.nih.gov/33125726
https://pubmed.ncbi.nlm.nih.gov/33125726
Autor:
Andre Fischer, Dennis M. Krüger, Sarah Köster, Tea Berulava, Gerrit Brehm, Rezaul Islam, Robert Epple
Publikováno v:
Mol Neurobiol
Molecular neurobiology 58(6), 2940-2953 (2021). doi:10.1007/s12035-021-02296-y
Molecular Neurobiology
Molecular neurobiology 58(6), 2940-2953 (2021). doi:10.1007/s12035-021-02296-y
Molecular Neurobiology
Neurons are highly compartmentalized cells that depend on local protein synthesis. Messenger RNAs (mRNAs) have thus been detected in neuronal dendrites, and more recently in the pre- and postsynaptic compartments as well. Other RNA species such as mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71ab3d3b00a748e0e3acbc531878a2a
https://pubmed.ncbi.nlm.nih.gov/33710584
https://pubmed.ncbi.nlm.nih.gov/33710584
Autor:
Thomas Endres, Stefan Vielhaber, Kerstin Hallmann, Niki Karavasili, Marten Szibor, Frank Schreiber, T. M. Gainutdinov, Volkmar Lessmann, Michael Schwarzer, Zemfira Gizatullina, Torsten Doenst, Matthias Kunz, Wolfram S. Kunz, Grazyna Debska-Vielhaber, Frank N. Gellerich, Alexandra Bamberger, Hans-Jochen Heinze
Publikováno v:
The journal of biological chemistry 295(14), 4383-4397 (2020). doi:10.1074/jbc.RA119.011902
The journal of biological chemistry, 295(14):4383-4397
The Journal of Biological Chemistry
The journal of biological chemistry, 295(14):4383-4397
The Journal of Biological Chemistry
Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3d6448d2f54ea5c8e34997c143a0fa
Autor:
Volkmar Gieselmann, Nahal Brocke-Ahmadinejad, Frederic Brosseron, Marc Sylvester, Teodora Stella Wijasa, Markus P. Kummer, Michael T. Heneka
Publikováno v:
Journal of neuroscience methods 291, 95-100 (2017). doi:10.1016/j.jneumeth.2017.08.005
Journal of Neuroscience Methods
Journal of Neuroscience Methods
Graphical abstract
Highlights • Protocol for quantitative proteomics of nitrosylation on synaptosomal proteins. • Identification of endogenous nitrosylation independent of induction by NO donors. • Use of iodoTMT sixplex mass tags for stab
Highlights • Protocol for quantitative proteomics of nitrosylation on synaptosomal proteins. • Identification of endogenous nitrosylation independent of induction by NO donors. • Use of iodoTMT sixplex mass tags for stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2e643a86d6d28e1cd8ab1fcc228c78
https://pub.dzne.de/record/139562
https://pub.dzne.de/record/139562
Autor:
Eva Benito, Jeffrey McIlhinney, Hamid Ahmad, Saheeb Ahmed, Joaquin I. Hurtado-Zavala, Binu Ramachandran, Pavel V Perestenko, Katja Burk, Aarti Swaminathan, Camin Dean, Ankit Awasthi, Ruth Faram, Andre Fischer
Publikováno v:
Cerebral cortex 28(4), 1087-1104 (2017). doi:10.1093/cercor/bhx009
Dendritic spines compartmentalize information in the brain, and their morphological characteristics are thought to underly synaptic plasticity. Here we identify copine-6 as a novel modulator of dendritic spine morphology. We found that brain-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69651459715fc20ba48cd6dc51e4d13
https://pubmed.ncbi.nlm.nih.gov/28158493
https://pubmed.ncbi.nlm.nih.gov/28158493
Autor:
Patrícia Guerreiro, Maria L. Orcellet, Roger S. Goody, Christian Griesinger, Stefan Becker, Tiago F. Outeiro, Flaviano Giorgini, Sibylle E. Eisbach, Diana F. Lázaro, Aymelt Itzen, Éva M. Szegő, Ane Martin Anduaga, Carlo Breda, Gerhard H. Braus, Tomás Lopes da Fonseca, Guowei Yin, Claudio O. Fernández, Markus Zweckstetter
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Neurobiology of disease 70, 149-161 (2014). doi:10.1016/j.nbd.2014.06.018
Neurobiology of Disease, Vol 70, Iss, Pp 149-161 (2014)
Neurobiology of Disease
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Neurobiology of disease 70, 149-161 (2014). doi:10.1016/j.nbd.2014.06.018
Neurobiology of Disease, Vol 70, Iss, Pp 149-161 (2014)
Neurobiology of Disease
Alpha-synuclein (αS) misfolding is associated with Parkinson's disease (PD) but little is known about the mechanisms underlying αS toxicity. Increasing evidence suggests that defects in membrane transport play an important role in neuronal dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88f75271e75c932d694f14aea38eaf6
https://pubmed.ncbi.nlm.nih.gov/24983211
https://pubmed.ncbi.nlm.nih.gov/24983211