Výsledky vyhledávání - "metabolism [Synaptosomal-Associated Protein 25]"

Therapeutic effectiveness of botulinum neurotoxin A: Potent blockade of autonomic transmission by targeted cleavage of only the pertinent SNAP-25

Autor: Saak V. Ovsepian, K. Roger Aoki, Gary W. Lawrence, J. Oliver Dolly, Jiafu Wang

Publikováno v: Neuropharmacology 70, 287-295 (2013). doi:10.1016/j.neuropharm.2013.02.012

In search of a basis for the impressive potency of an endoprotease that cleaves SNAP-25, botulinum neurotoxin type A (BoNT/A), in treating numerous diseases due to hyper-active autonomic nerves, truncation of its target and inhibition of neurotransmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317a38f6ad08566639e25f14f4de7d13
https://doi.org/10.1016/j.neuropharm.2013.02.012

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Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and trans-synaptic propagation at central synapses exceed those of its C-terminal-binding fragments

Autor: Ovsepian, Saak V, Ovespian, Saak V, Bodeker, MacDara, O'Leary, Valerie B, Lawrence, Gary W, Oliver Dolly, J.

Publikováno v: Brain structure & function 220(3), 1825-1838 (2015). doi:10.1007/s00429-015-1004-0

The prominent tropism of tetanus toxin (TeTx) towards peripheral nerves with retrograde transport and transfer to central neurons render it an invaluable probe for exploring fundamental neuronal processes such as endocytosis, retrograde trafficking a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b43cca9a3498b5543e5f0dded563bb
https://pub.dzne.de/record/137904

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Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds

Autor: Annalisa Santucci, Prashant P. Mehta, Bibhuti R. DasGupta, Jaime Jontes, Fabio Benfenati, Cesare Montecucco, Giampietro Schiavo, Michael Wilson

Publikováno v: Scopus-Elsevier

SNAP-25, a membrane-associated protein of the nerve terminal, is specifically cleaved by botulinum neurotoxins serotypes A and E, which cause human and animal botulism by blocking neurotransmitter release at the neuromuscular junction. Here we show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98a878aa9af1123211d723dfac3813a

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