Zobrazeno 1 - 10
of 28
pro vyhledávání: '"metabolism [Synaptic Vesicles]"'
Publikováno v:
Trends in neurosciences 46(4), 293-306 (2023). doi:10.1016/j.tins.2023.01.001
Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release, synapses need to maintain an adequate pool of SVs at all times. Deca
Autor:
Garner, Craig, Ackermann, Frauke
Publikováno v:
Molecular and cellular neuroscience 124, 103795 (2023). doi:10.1016/j.mcn.2022.103795
Properly working synapses are one important guarantor for a functional and healthy brain. They are small, densely packed structures, where information is transmitted through the release of neurotransmitters from synaptic vesicles (SVs). The latter cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68d445588caeaaa0e207bb1bb44cbbe
Autor:
Marta Orlando, Felicitas Bruentgens, Jörg Breustedt, Benjamin R. Rost, Stephan J. Sigrist, Dietmar Schmitz, Marta Maglione, Anton Dvorzhak
Publikováno v:
PLoS Biology, Vol 19, Iss 6, p e3001149 (2021)
PLoS Biology
PLoS biology 19(6), e3001149 (2021). doi:10.1371/journal.pbio.3001149
PLoS Biology
PLoS biology 19(6), e3001149 (2021). doi:10.1371/journal.pbio.3001149
Synaptic plasticity is a cellular model for learning and memory. However, the expression mechanisms underlying presynaptic forms of plasticity are not well understood. Here, we investigate functional and structural correlates of presynaptic potentiat
Autor:
Ivan Silbern, Henning Urlaub, Reinhard Jahn, Kuan-Ting Pan, Stefan Bonn, Maksims Fiosins, Silvio O. Rizzoli, Eugenio F. Fornasiero
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061
Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming action potential, voltage-gated calcium channels open, resulting in the influx of calcium ions that trigge
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and molecular life sciences, 78(6):2621-2639
Cellular and molecular life sciences 78(6), 2621-2639 (2021). doi:10.1007/s00018-020-03722-5
Cellular and molecular life sciences, 78(6):2621-2639
Cellular and molecular life sciences 78(6), 2621-2639 (2021). doi:10.1007/s00018-020-03722-5
The complex morphology of neurons, the specific requirements of synaptic neurotransmission and the accompanying metabolic demands create a unique challenge for proteostasis. The main machineries for neuronal protein synthesis and degradation are loca
Autor:
Pietro De Camilli, Goeun Kim, Sangeun Lee, Yumei Wu, Seonyoung Jeong, Sunghoe Chang, Dragomir Milovanovic, Daehun Park
Publikováno v:
Nature Communications
Nature Communications 12(1), 263 (2021). doi:10.1038/s41467-020-20462-z
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications 12(1), 263 (2021). doi:10.1038/s41467-020-20462-z
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Clusters of tightly packed synaptic vesicles (SVs) are a defining feature of nerve terminals. While SVs are mobile within the clusters, the clusters have no boundaries consistent with a liquid phase. We previously found that purified synapsin, a peri
Autor:
Carla Perego, Franco Onofri, Maria Perez Carrion, Christian Johannes Gloeckner, Zeila Casiraghi, Felix von Zweydorf, P. Marciani, Giovanni Piccoli, Francesca Pischedda, Antonella Marte, A. Marku
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific reports 10(1), 3799 (2020). doi:10.1038/s41598-020-60834-5
Scientific Reports
Scientific reports 10(1), 3799 (2020). doi:10.1038/s41598-020-60834-5
Scientific Reports
The LRRK2 protein consists of multiple functional domains, including protein-binding domains at its N and C-terminus. Mutations in the Leucine-rich repeat kinase 2 gene (LRRK2) have been linked to familial and sporadic Parkinson’s disease (PD). We
Autor:
Christian Hoffmann, Dragomir Milovanovic, Ayse Ulusoy, Giuseppe Morabito, R. Martin Vabulas, Roberto Sansevrino, Marcelo Ganzella, Chinyere Logan
Publikováno v:
Journal of molecular biology 433(12), 166961 (2021). doi:10.1016/j.jmb.2021.166961
Neurotransmission relies on the tight spatial and temporal regulation of the synaptic vesicle (SV) cycle. Nerve terminals contain hundreds of SVs that form tight clusters. These clusters represent a distinct liquid phase in which one component of the
Autor:
Sheila Hoffmann-Conaway, Anil Annamneedi, Craig C. Garner, Eckart D. Gundelfinger, Carolina Montenegro-Venegas
Publikováno v:
Autophagy
Autophagy 16(9), 1732-1733 (2020). doi:10.1080/15548627.2020.1801259
Autophagy 16(9), 1732-1733 (2020). doi:10.1080/15548627.2020.1801259
Maintaining the integrity and function of the presynaptic neurotransmitter release apparatus is a demanding process for a post-mitotic neuron; the mechanisms behind it are still unclear. BSN (bassoon), an active zone scaffolding protein, has been imp
Autor:
Sandra E. Encalada, Biao Li, Edgar Gutierrez, Eva-Maria Mandelkow, Mihir Vohra, David Soriano-Castell, Aimee W. Kao, Frank J.A. Dennissen, Juan A. Oses-Prieto, Austin L Wang, Dominique A. Salazar, Miguel Alves-Ferreira, Sean D. Mooney, Victoria J. Butler, Kaveh Ashrafi, Alma L. Burlingame, Kathy H. Li, Beibei Jing, Alex Groisman
Publikováno v:
Human molecular genetics, vol 28, iss 9
Human Molecular Genetics
Human molecular genetics 28(9), 1498-1514 (2018). doi:10.1093/hmg/ddy442
Human Molecular Genetics
Human molecular genetics 28(9), 1498-1514 (2018). doi:10.1093/hmg/ddy442
Mutations in the microtubule-associated protein tau (MAPT) underlie multiple neurodegenerative disorders, yet the pathophysiological mechanisms are unclear. A novel variant in MAPT resulting in an alanine to threonine substitution at position 152 (A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2fd562da33ba17969c5f579e917b05
https://escholarship.org/uc/item/18w0z80x
https://escholarship.org/uc/item/18w0z80x