Zobrazeno 1 - 8
of 8
pro vyhledávání: '"metabolism [Superoxide Dismutase-1]"'
Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice
Autor:
Stéphanie Millecamps, Michael T. Heneka, Félix Berriat, Matthieu Ribon, Delphine Bohl, Martine Rampanana, Céline Leone, Julie Cottin, Christian S Lobsiger, Séverine Boillée, Aude Chiot
Publikováno v:
Neurobiology of aging 101, 181-186 (2021). doi:10.1016/j.neurobiolaging.2021.01.015
Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2021, 101, pp.181-186. ⟨10.1016/j.neurobiolaging.2021.01.015⟩
Neurobiology of Aging, 2021, 101, pp.181-186. ⟨10.1016/j.neurobiolaging.2021.01.015⟩
Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2021, 101, pp.181-186. ⟨10.1016/j.neurobiolaging.2021.01.015⟩
Neurobiology of Aging, 2021, 101, pp.181-186. ⟨10.1016/j.neurobiolaging.2021.01.015⟩
International audience; Neuroinflammation is a hallmark of Amyotrophic Lateral Sclerosis (ALS) in hSOD1 G93A mouse models where microglial cells contribute to the progressive motor neuron degenerative process. S100-A8 and S100-A9 (also known as MRP8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2873bba22eb16906b8144217ed108b06
https://doi.org/10.1016/j.neurobiolaging.2021.01.015
https://doi.org/10.1016/j.neurobiolaging.2021.01.015
Autor:
René Günther, Arun Pal, Chloe Williams, Vitaly L. Zimyanin, Maria Liehr, Cläre von Neubeck, Mechthild Krause, Mrudula G. Parab, Susanne Petri, Norman Kalmbach, Stefan L. Marklund, Jared Sterneckert, Peter Munch Andersen, Florian Wegner, Jonathan D. Gilthorpe, Andreas Hermann
Publikováno v:
Cells; Volume 11; Issue 7; Pages: 1246
Cells 11(7), 1246 (2022). doi:10.3390/cells11071246 special issue: "Neurodegenerative and Neurologic Disease: Genes, Mechanisms, and Therapies"
Cells 11(2022), 1246
Cells 11(7), 1246 (2022). doi:10.3390/cells11071246 special issue: "Neurodegenerative and Neurologic Disease: Genes, Mechanisms, and Therapies"
Cells 11(2022), 1246
Little is known about the early pathogenic events by which mutant superoxide dismutase 1 (SOD1) causes amyotrophic lateral sclerosis (ALS). This lack of mechanistic understanding is a major barrier to the development and evaluation of efficient thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0067abdc1aad691e6998f268be42c22d
Autor:
Daniel Zytnicki, Marcin Bączyk, Nicolas Doisne, Clémence Martinot, Najwa Ouali Alami, Barbara Commisso, Nicolas Delestrée, Francesco Roselli, David Bayer, Marin Manuel, Linyun Tang, Wayne N. Frankel
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (8), ⟨10.1084/jem.20191734⟩
The Journal of Experimental Medicine
Journal of experimental medicine 217(8), e20191734 (2020). doi:10.1084/jem.20191734
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (8), ⟨10.1084/jem.20191734⟩
The Journal of Experimental Medicine
Journal of experimental medicine 217(8), e20191734 (2020). doi:10.1084/jem.20191734
This study demonstrates that, in a mouse model of ALS, excitatory synapses on spinal motoneurons are disrupted. Activation of the cAMP/PKA pathway reverts the functional and structural synaptic deficits and ameliorates disease markers by increasing m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ee2bfc13e2b37563ad14e712f1530a
https://doi.org/10.1084/jem.20191734
https://doi.org/10.1084/jem.20191734
Publikováno v:
International journal of molecular sciences 21(18), 6938-(2020). doi:10.3390/ijms21186938
International Journal of Molecular Sciences
Volume 21
Issue 18
International Journal of Molecular Sciences, Vol 21, Iss 6938, p 6938 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 18
International Journal of Molecular Sciences, Vol 21, Iss 6938, p 6938 (2020)
Amyotropic lateral sclerosis (ALS) is a lethally progressive and irreversible neurodegenerative disease marked by apparent death of motor neurons present in the spinal cord, brain stem and motor cortex. While more and more gene mutants being establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d29795516a3bf903129529c3d5293e1
Autor:
Phillip C. Wong, Diana Wiesner, Francesco Roselli, Tobias M. Boeckers, Deniz Yilmazer-Hanke, Barbara Commisso, Linyun Tang, Albert C. Ludolph, Jochen H. Weishaupt, Najwa Ouali Alami, Luc Dupuis, David Bayer, Bernd Baumann, Thomas Wirth
Publikováno v:
Life science alliance 3(11), e201900571 (2020). doi:10.26508/lsa.201900571
Life Science Alliance
Life Science Alliance, Life Science Alliance LLC, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩
Life Science Alliance, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩
Life Science Alliance
Life Science Alliance, Life Science Alliance LLC, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩
Life Science Alliance, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩
Chemogenetic motoneuron excitation and astrocyte GPCR-Gi signaling restore blood–spinal cord barrier, disrupted in four ALS mouse models, revealing its role in disease progression but not initiation.
Blood–spinal cord barrier (BSCB) disrupti
Blood–spinal cord barrier (BSCB) disrupti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93218dfe1100975b7bc1fb24ea761df4
https://pub.dzne.de/record/164314
https://pub.dzne.de/record/164314
Autor:
Thomas Brännström, Matthis Synofzik, Elin Forsgren, Jonathan D. Gilthorpe, Ulrika Nordström, Per Zetterström, Isil Keskin, Stefan L. Marklund, Manuela Lehmann, Dale J. Lange, Peter M. Andersen
Publikováno v:
Acta Neuropathologica
Acta neuropathologica 138(1), 85-101 (2019). doi:10.1007/s00401-019-01986-1
Acta neuropathologica 138(1), 85-101 (2019). doi:10.1007/s00401-019-01986-1
Mutations in superoxide dismutase 1 (SOD1) cause amyotrophic lateral sclerosis (ALS). Disease pathogenesis is linked to destabilization, disorder and aggregation of the SOD1 protein. However, the non-genetic factors that promote disorder and the subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc4c73bc2b56586cb4077b135696acf
https://pubmed.ncbi.nlm.nih.gov/30863976
https://pubmed.ncbi.nlm.nih.gov/30863976
Autor:
Asaf Madi, Elaine O’Loughlin, Anna Worthmann, Oleg Butovsky, Lien Beckers, Tsuneya Ikezu, Frank L. Heppner, Kristin Hartmann, Vladimir Litvak, Mar Gacias, Markus Glatzel, Zain Fanek, Zachary Humulock, Howard L. Weiner, Susanne Krasemann, Joerg Heeren, Jordi Ochando, Zhiping Weng, Ron Cialic, Christian Haass, Yang Xu, Narghes Calcagno, David M. Holtzman, Tobias Zrzavy, Bogdan Budnik, Cynthia A. Lemere, George Tweet, Hans Lassmann, Scott T. Smith, Hao Chen, Caroline Baufeld, Rachid El Fatimy, David J. Greco, Charlotte Madore, Fargol Mazaheri, Emily C. Tjon, Patricia Conde-Sanroman, Jason D. Ulrich
Publikováno v:
Immunity 47(3), 566-581.e9 (2017). doi:10.1016/j.immuni.2017.08.008
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1c04d37b48c4a61a63dc78d139d1b0
https://pub.dzne.de/record/139513
https://pub.dzne.de/record/139513
Autor:
Maria Carmen Garza, Babila J. Tachu, Katharina Annick Wüsten, Gültekin Tamgüney, Holger Wille
Publikováno v:
Protein expression and purification 134, 63-71 (2017). doi:10.1016/j.pep.2017.04.001
• Expression of untagged wild-type and mutant human superoxide dismutase 1 (SOD1) proteins in the periplasm of E. coli.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55c1894ca970972acb9e70fae795c48
https://pubmed.ncbi.nlm.nih.gov/28385582
https://pubmed.ncbi.nlm.nih.gov/28385582