Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Autor: Teemu Smura, Frederic A. Meunier, Minou Djannatian, Jonas Franz, Martin Sebastian Winkler, Christine Stadelmann, Leonora Szirovicza, Brit Mollenhauer, Ari Helenius, Pamela Österlund, Olli Vapalahti, Tuğberk Kaya, Sarah J. Butcher, Maria Anastasina, Lev Levanov, Ravi Ojha, Suvi Kuivanen, Ludovico Cantuti-Castelvetri, Mikael Simons, Hannimari Kallio-Kokko, Ozgun Gokce, Giuseppe Balistreri, Katri Kallio, Merja Joensuu, Liliana D. Pedro, Allan Tobi, Franziska van der Meer, Tambet Teesalu, Jussi Hepojoki

Publikováno v: Science
Science, 370 (6518)
Science (New York, N.y.)
Science / Science now 370(6518), 856-860 (2020). doi:10.1126/science.abd2985
Signal Transduction and Targeted Therapy

Another host factor for SARS-CoV-2 Virus-host interactions determine cellular entry and spreading in tissues. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d602d02c0f3dd0c2860bc58f052583

A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors

Autor: Cédric Feschotte, Manvendra K. Singh, Vikas Bansal

Publikováno v: Cell Reports
Cell Reports, Vol 32, Iss 12, Pp 108175-(2020)
Cell reports 32(12), 108175 (2020). doi:10.1016/j.celrep.2020.108175
SSRN
bioRxiv
article-version (status) pre
article-version (number) 2

To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-associated receptors and factors (SCARFs) using single-cell transcriptomics across various healthy human tissues. SCARFs include cellular factors both facilitatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53de96471dee3f2ce03610e0ebd50321
http://europepmc.org/articles/PMC7470764

Reelin expression in Creutzfeldt-Jakob disease and experimental models of transmissible spongiform encephalopathies

Autor: Jesús R. Requena, Juan María Torres, Franc Llorens, Inga Zerr, Isidro Ferrer, Agata Mata, Katrin Thüne, Alejandro M. Sevillano, Silvia Vilches, Rosalina Gavín, Olivier Andreoletti, Juan Carlos Espinosa, Laura Urrea, José Antonio del Río

Publikováno v: Repositorio de Resultados de Investigación del INIA
INIA: Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2017, 54 (8), pp.6412-6425. ⟨10.1007/s12035-016-0177-8⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Molecular neurobiology 54(8), 6412-6425 (2016). doi:10.1007/s12035-016-0177-8

Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are mediated by the intracellular ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9b7f6eb472672bf32b4d8f6fe47b0c
https://hdl.handle.net/20.500.12792/2828

A Disulfide Bond-Containing Alkaline Phosphatase Triggers a BdbC-Dependent Secretion Stress Response in Bacillus subtilis

Autor: Michael Hecker, Wim J. Quax, Sierd Bron, Ronald Dorenbos, Elise Darmon, Jan Maarten van Dijl, Haike Antelmann, Roland Freudl, Jean-Yves F. Dubois, Oscar P. Kuipers, Jochen Meens

Publikováno v: Applied and environmental microbiology, 72(11), 6876-6885. AMER SOC MICROBIOLOGY
Applied and environmental microbiology 72, 6876-6885 (2006). doi:10.1128/AEM.01176-06

The gram-positive bacterium Bacillus subtilis secretes high levels of proteins into its environment. Most of these secretory proteins are exported from the cytoplasm in an unfolded state and have to fold efficiently after membrane translocation. As p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1db744853adbe252999feec38222ec
https://doi.org/10.1128/aem.01176-06

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2

Autor: Enrico Glaab, Thomas Ott, Hartwig Wolburg, Stefan Helling, Julia C. Fitzgerald, Rejko Krüger, Caroline May, Jing Chen, Katrin Marcus, Nicolas Casadei, Poonam Sood, Silke Nuber, Olaf Riess, Petra Fallier-Becker, Doron Rapaport, Thomas Ulrich, Nicole Kieper

Publikováno v: Human molecular genetics 25(24), ddw353 (2016). doi:10.1093/hmg/ddw353
Human molecular genetics 25(3), 459-471 (2015). doi:10.1093/hmg/ddv485
Human Molecular Genetics

The protease HtrA2 has a protective role inside mitochondria, but promotes apoptosis under stress. We previously identified the G399S HtrA2 mutation in Parkinson's disease (PD) patients and reported mitochondrial dysfunction in vitro. Mitochondrial d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f17945c47908f8982a83e5f350b4750
https://doi.org/10.1093/hmg/ddw353