Výsledky vyhledávání - "metabolism [Serine]"

An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning

Autor: Kirsten Bohmbach, Nicola Masala, Eva M. Schönhense, Katharina Hill, André N. Haubrich, Andreas Zimmer, Thoralf Opitz, Heinz Beck, Christian Henneberger

Publikováno v: Nature Communications 13(1), 7932 (2022). doi:10.1038/s41467-022-35620-8

Dendrites of hippocampal CA1 pyramidal cells amplify clustered glutamatergic input by activation of voltage-gated sodium channels and N-methyl-D-aspartate receptors (NMDARs). NMDAR activity depends on the presence of NMDAR co-agonists such as D-serin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8eeecb37800295e64926a02448fd6d

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GBA Mutations Influence the Release and Pathological Effects of Small Extracellular Vesicles from Fibroblasts of Patients with Parkinson’s Disease

Autor: Micol Avenali, Gerardo Ongari, Stefania Croce, Cristina Ghezzi, Silvia Cerri, Donato A. Di Monte, Fabio Blandini, Roberta Zangaglia, Enza Maria Valente

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2215, p 2215 (2021)
International journal of molecular sciences 22(4), 2215 (2021). doi:10.3390/ijms22042215
International Journal of Molecular Sciences
Volume 22
Issue 4

Heterozygous mutations in the GBA gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), are the strongest known genetic risk factor for Parkinson’s disease (PD). The molecular mechanisms underlying the increased PD risk and the variable p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9f135670233cc83ce5569d9444f633
https://www.mdpi.com/1422-0067/22/4/2215

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An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

Autor: Regina Feederle, Christian Haass, Akio Fukumori, Kai Schlepckow, Stefan F. Lichtenthaler, Gernot Kleinberger, Harald Steiner

Publikováno v: EMBO Molecular Medicine
EMBO molecular medicine 9(10), 1356-1365 (2017). doi:10.15252/emmm.201707672

Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) support an essential function of microglia and innate immunity in the pathogenesis of Alzheimer’s disease (AD) and other neurodegenerati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f94700a37bd71d3afaa296089b0ff15
http://europepmc.org/articles/PMC5623859

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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Autor: W. Samantha N. Jayasekara, Cynthia Louis, Hassan Albargy, Kevin Luu, Katherine A. Fitzgerald, Francis J. Kirby, Finbar Mansell, Jesse J. Balic, Daniel J. Garama, Eicke Latz, Fiachra Humphries, Ashley Mansell, Nikola Baschuk, Daniel J. Gough, Dominic De Nardo

Publikováno v: Nature Communications 11(1), 3816 (2020). doi:10.1038/s41467-020-17669-5
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor (TLR)-4 expressed on macrophages induces a robust pro-inflammatory response which has recently been shown to be dependent on metabolic reprogramming 1, 2, 3, 4.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d96f36776d72d1c4575633c91b3361

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Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Publikováno v: Science
Science, 370 (6518)
Science (New York, N.y.)
Science / Science now 370(6518), 856-860 (2020). doi:10.1126/science.abd2985
Signal Transduction and Targeted Therapy

Another host factor for SARS-CoV-2 Virus-host interactions determine cellular entry and spreading in tissues. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a recept

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Disease-Specific Changes in Reelin Protein and mRNA in Neurodegenerative Diseases

Autor: Miguel Aguilar, Laia Lidón, Ignacio Alvarez, Enric Vidal, Inga Zerr, Vanessa Gil, Pau Pastor, Laura Urrea, José Antonio del Río, Isidre Ferrer, Monica Diez-Fairen, Alberto Lleó, Franc Llorens, Daniel Alcolea, Rosalina Gavín

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
IRTA Pubpro. Open Digital Archive
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Cells
Dipòsit Digital de la UB
Universidad de Barcelona
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Cells 9(5), 1252 (2020). doi:10.3390/cells9051252
Cells, Vol 9, Iss 1252, p 1252 (2020)
Volume 9
Issue 5

Reelin is an extracellular glycoprotein that modulates neuronal function and synaptic plasticity in the adult brain. Decreased levels of Reelin activity have been postulated as a key factor during neurodegeneration in Alzheimer´
s disease (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877c752f3c85b5cbb45640ffae9417fe
https://ddd.uab.cat/record/252622

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Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis

Autor: Yuan Shi, Elena Montagna, Sophie Crux, Song Shi, Kaichuan Zhu, Chengyu Zou, Mario M. Dorostkar, Carmelo Sgobio, Jochen Herms, Stéphane Marinesco, Ulrike Müller

Publikováno v: The EMBO journal 35(20), 2213-2222 (2016). doi:10.15252/embj.201694085
The EMBO Journal

Dynamic synapses facilitate activity‐dependent remodeling of neural circuits, thereby providing the structural substrate for adaptive behaviors. However, the mechanisms governing dynamic synapses in adult brain are still largely unknown. Here, we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a2078bd453643fd02f7527a1bbfdc9
https://doi.org/10.15252/embj.201694085

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A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors

Autor: Cédric Feschotte, Manvendra K. Singh, Vikas Bansal

Publikováno v: Cell Reports
Cell Reports, Vol 32, Iss 12, Pp 108175-(2020)
Cell reports 32(12), 108175 (2020). doi:10.1016/j.celrep.2020.108175
SSRN
bioRxiv
article-version (status) pre
article-version (number) 2

To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-associated receptors and factors (SCARFs) using single-cell transcriptomics across various healthy human tissues. SCARFs include cellular factors both facilitatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53de96471dee3f2ce03610e0ebd50321
http://europepmc.org/articles/PMC7470764

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Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons

Autor: Cathleen Hagemann, Ankita Ravi Vaswani, Hans-Ulrich Fried, Beatrice Weykopf, Oliver Brüstle, Sandra Blaess

Publikováno v: eLife 8, e41623 (2019). doi:10.7554/eLife.41623
eLife, Vol 8 (2019)
eLife

Midbrain dopaminergic (mDA) neurons migrate to form the laterally-located substantia nigra pars compacta (SN) and medially-located ventral tegmental area (VTA), but little is known about the underlying cellular and molecular processes. Here we visual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16e9515bb9ac1da90dcaee268fb3cd2
https://pub.dzne.de/record/140450

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