Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia

Autor: Ashkan Emadi, Kanwal Mahmood

Publikováno v: Pharmaceuticals, Vol 14, Iss 190, p 190 (2021)
Pharmaceuticals

Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Studies in hematological malignancies have shown alterations in fatty acid, folate, and amino acid metabolism pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a3a0abd8768e2e3e82772e3249bab7
https://www.mdpi.com/1424-8247/14/3/190

An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning

Autor: Kirsten Bohmbach, Nicola Masala, Eva M. Schönhense, Katharina Hill, André N. Haubrich, Andreas Zimmer, Thoralf Opitz, Heinz Beck, Christian Henneberger

Publikováno v: Nature Communications 13(1), 7932 (2022). doi:10.1038/s41467-022-35620-8

Dendrites of hippocampal CA1 pyramidal cells amplify clustered glutamatergic input by activation of voltage-gated sodium channels and N-methyl-D-aspartate receptors (NMDARs). NMDAR activity depends on the presence of NMDAR co-agonists such as D-serin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8eeecb37800295e64926a02448fd6d

GBA Mutations Influence the Release and Pathological Effects of Small Extracellular Vesicles from Fibroblasts of Patients with Parkinson’s Disease

Autor: Micol Avenali, Gerardo Ongari, Stefania Croce, Cristina Ghezzi, Silvia Cerri, Donato A. Di Monte, Fabio Blandini, Roberta Zangaglia, Enza Maria Valente

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2215, p 2215 (2021)
International journal of molecular sciences 22(4), 2215 (2021). doi:10.3390/ijms22042215
International Journal of Molecular Sciences
Volume 22
Issue 4

Heterozygous mutations in the GBA gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), are the strongest known genetic risk factor for Parkinson’s disease (PD). The molecular mechanisms underlying the increased PD risk and the variable p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9f135670233cc83ce5569d9444f633
https://www.mdpi.com/1422-0067/22/4/2215

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Autor: W. Samantha N. Jayasekara, Cynthia Louis, Hassan Albargy, Kevin Luu, Katherine A. Fitzgerald, Francis J. Kirby, Finbar Mansell, Jesse J. Balic, Daniel J. Garama, Eicke Latz, Fiachra Humphries, Ashley Mansell, Nikola Baschuk, Daniel J. Gough, Dominic De Nardo

Publikováno v: Nature Communications 11(1), 3816 (2020). doi:10.1038/s41467-020-17669-5
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor (TLR)-4 expressed on macrophages induces a robust pro-inflammatory response which has recently been shown to be dependent on metabolic reprogramming 1, 2, 3, 4.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d96f36776d72d1c4575633c91b3361