FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress

Autor: Fernando Gómez-Herreros, Philip Van Damme, Marcel Naumann, Duncan A. Q. Moore, María Isabel Martínez-Macías, Ryan L. Green, Majid Hafezparast, Andreas Hermann, Keith W. Caldecott

Publikováno v: Life Science Alliance
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
Life science alliance 2(2), e201800222 (2019). doi:10.26508/lsa.201800222

FUS (fused in sarcoma) plays a key role in several steps of RNA metabolism, and dominant mutations in this protein are associated with neurodegenerative diseases. Here, we show that FUS is a component of the cellular response to topoisomerase I (TOP1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a997c0650dddf63f90e8dfd173f3753
http://europepmc.org/articles/PMC6391683