Zobrazeno 1 - 10
of 63
pro vyhledávání: '"metabolism [Proto-Oncogene Proteins]"'
Autor:
Silvia Cases-Cunillera, Karen M J van Loo, Julika Pitsch, Anne Quatraccioni, Sugirthan Sivalingam, Paolo Salomoni, Valeri Borger, Dirk Dietrich, Susanne Schoch, Albert J Becker
Publikováno v:
Neuro-Oncology 24(5), 741-754 (2022). doi:10.1093/neuonc/noab268
Neuro-Oncology 24(5), 741-754 (2022). doi:10.1093/neuonc/noab268
Published by Oxford Univ. Press, Oxford
Published by Oxford Univ. Press, Oxford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c084401789e468e8a20d91d828e5463a
Autor:
Lamya Yamani, Frances R. Balkwill, Federica M. Marelli-Berg, Juho Vuononvirta, Melania Capasso, Eleanor J. Ward, Suchita Nadkarni, Maryam Jangani
Publikováno v:
Journal of leukocyte biology 111(5), 967-980 (2022). doi:10.1002/JLB.1A0920-588R
Monocyte migration to the sites of inflammation and maturation into macrophages are key steps for their immune effector function. Here, we show that mechanistic target of rapamycin complex 2 (mTORC2)-dependent Akt activation is instrumental for metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c37bac8cd8d674c7b85b94c49a2a57
https://pub.dzne.de/record/162927
https://pub.dzne.de/record/162927
Autor:
Wolfgang Wurst, Thomas Ott, Kathrin Brockmann, Daniela Vogt-Weisenhorn, Andrea Wenninger-Weinzierl, Marita Munz, Ralf Kühn, Saskia Biskup, Florian Giesert, Natalja Funk, Thomas Gasser
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific reports 9(1), 4515 (2019). doi:10.1038/s41598-019-40808-y
Scientific Reports
Scientific reports 9(1), 4515 (2019). doi:10.1038/s41598-019-40808-y
Scientific Reports
Mutations within Leucine-rich repeat kinase 2 (LRRK2) are associated with late-onset Parkinson’s disease. The physiological function of LRRK2 and molecular mechanism underlying the pathogenic role of LRRK2 mutations remain uncertain. Here, we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9ccd730fe7023ec1eb8e959bc4ec6f
http://link.springer.com/article/10.1038/s41598-019-40808-y
http://link.springer.com/article/10.1038/s41598-019-40808-y
Autor:
Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Händler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jörg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Melania Capasso, Rachael Nimmo, Paolo Salomoni
Publikováno v:
Nature cell biology 23(12), 1224-1239 (2021). doi:10.1038/s41556-021-00774-y
Nature Cell Biology
Nature Cell Biology
Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee13b2bcc75258f28371f3d227cfcfb
https://pub.dzne.de/record/163640
https://pub.dzne.de/record/163640
Autor:
Jutta Ludwig-Müller, Tara L. Walker, Zeina Nicola, Merve Bulut, Gerd Kempermann, Alex M. Sykes, Leonardo Ortiz-López, Rupert W. Overall, Muhammad Ichwan, Vijay S. Adusumilli, Gerardo Ramírez-Rodríguez, Christoph Böttcher, Norbert Hubner, Enrique A. Lugo-Hernández
Publikováno v:
Stem cell reports 16(3), 548-565 (2021). doi:10.1016/j.stemcr.2021.01.005
Stem Cell Reports
Stem Cell Reports
Summary As mammals evolved with exposure to particular diets, naturally abundant compounds may have become part of the set of environmental co-determinants that shaped brain structure and function. Here we investigated whether bioactive factors found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e15b0ea64c8d6286e334014b640ae6b
https://pub.dzne.de/record/157719
https://pub.dzne.de/record/157719
Autor:
Patrick Yu-Wai-Man, Christoph Ufer, Lynn Bedford, David J. Boocock, Theodosis S. Theodosi, Aslihan Ugun-Klusek, Julia C. Fitzgerald, E. Ellen Billett, Florence Burté
Publikováno v:
Redox Biology, Vol 20, Iss, Pp 167-181 (2019)
Redox Biology 20, 167-181 (2019). doi:10.1016/j.redox.2018.10.003
Redox Biology
Redox Biology 20, 167-181 (2019). doi:10.1016/j.redox.2018.10.003
Redox Biology
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and contribute to reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee6c7f7a07ce2d77e3885777776be6e
http://www.sciencedirect.com/science/article/pii/S2213231718307341
http://www.sciencedirect.com/science/article/pii/S2213231718307341
Autor:
Pantoja-Escobar, Gerardo, Morales-Martínez, Mario, Vega, Gabriel G, Castro-Escarpulli, Graciela, Vega, Mario I
Publikováno v:
Leukemia & lymphoma, vol 60, iss 4
The interaction between CD40, and its ligand, CD154, is essential for the development of humoral and cellular immune responses. The selective inhibition or activation of this pathway forms the basis for the development of new therapeutics against imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::11744bdba315bcc5a30e1bf34940aef0
https://escholarship.org/uc/item/3nj9g30m
https://escholarship.org/uc/item/3nj9g30m
Autor:
Josef Priller, Steffen Jung, Slava Epelman, Nora Hagemeyer, Sten Linnarsson, Marta Joana Costa Jordão, Fabio M.V. Rossi, Martin Kerschensteiner, Katrin Kierdorf, Fabiola Prutek, Frederic Geissmann, Lukas Amann, Tobias Goldmann, Robert Zeiser, Martin Krueger, Giuseppe Locatelli, Ori Staszewski, Peter Wieghofer, Ingo Bechmann, Marco Prinz, Hannah Hochgerner, Kathrin Frenzel
Publikováno v:
Nature immunology 17(7), 797-805 (2016). doi:10.1038/ni.3423
Perivascular, subdural meningeal and choroid plexus macrophages are non-parenchymal macrophages that mediate immune responses at brain boundaries. Although the origin of parenchymal microglia has recently been elucidated, much less is known about the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e27dc8425e610ce09399e4c9e73a1c
https://doi.org/10.1038/ni.3423
https://doi.org/10.1038/ni.3423
Autor:
Muhammad Ichwan, Gerd Kempermann, Alex M. Sykes, Susann Ruhwald, Tara L. Walker, Steffen Vogler, Rupert W. Overall, Klaus Fabel, Daniela Lasse
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 6, Iss 4, Pp 552-565 (2016)
Stem cell reports 6(4), 552-565 (2016). doi:10.1016/j.stemcr.2016.03.002
Stem Cell Reports, Vol 6, Iss 4, Pp 552-565 (2016)
Stem cell reports 6(4), 552-565 (2016). doi:10.1016/j.stemcr.2016.03.002
Summary Here, we show that the lysophosphatidic acid receptor 1 (LPA1) is expressed by a defined population of type 1 stem cells and type 2a precursor cells in the adult mouse dentate gyrus. LPA1, in contrast to Nestin, also marks the quiescent stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70674d519c5669d2edd766089c10578a
Autor:
Anton Ivanov, Vu Thao Quyen Le-Schulte, Christophe Bernard, Fabio Morellini, Ronny Eichler, Axel Neu, Stephan Lawrence Marguet, Igor Jakovcevski, Ileana L. Hanganu-Opatz, Dirk Isbrandt, Andrea Merseburg
Publikováno v:
Nature medicine 21(12), 1436-1444 (2015). doi:10.1038/nm.3987
The nervous system is vulnerable to perturbations during specific developmental periods. Insults during such susceptible time windows can have long-term consequences, including the development of neurological diseases such as epilepsy. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99de2fcb9965b9b6f993ba22f2b06d6b
https://doi.org/10.1038/nm.3987
https://doi.org/10.1038/nm.3987