Výsledky vyhledávání - "metabolism [Potassium]"

Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons

Publikováno v: Hippocampus 29(9), 817-835 (2019). doi:10.1002/hipo.23078

The hippocampal formation plays a role in mnemonic tasks and epileptic discharges in vivo. In vitro, these functions and malfunctions may relate to persistent firing (PF) and depolarization block (DB), respectively. Pyramidal neurons of the CA1 field

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f985149b4b4365875edba3bc9e2be38
https://doi.org/10.1002/hipo.23078

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Distinguishing features of microglia- and monocyte-derived macrophages after stroke

Autor: Lilian Staerck, Golo Kronenberg, Helmut Kettenmann, Friederike Klempin, Stephanie Wegner, Karen Gertz, Wolfgang Uckert, Nadine Richter, Matthias Endres, Ria Uhlemann, Susanne A. Wolf

Publikováno v: Acta neuropathologica 135(4), 551-568 (2017). doi:10.1007/s00401-017-1795-6

After stroke, macrophages in the ischemic brain may be derived from either resident microglia or infiltrating monocytes. Using bone marrow (BM)-chimerism and dual-reporter transgenic fate mapping, we here set out to delimit the responses of either ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a437546f0aa140714a4c266aabf7cc
https://doi.org/10.1007/s00401-017-1795-6

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The Role of the Voltage-Gated Potassium Channel Proteins Kv8.2 and Kv2.1 in Vision and Retinal Disease: Insights from the Study of Mouse Gene Knock-Out Mutations

Autor: David M. Hunt, Nathan S. Hart, Melanie Barth, Paula I. Fuller-Carter, Jeanne M. Nerbonne, Valentina Voigt, Jessica K. Mountford, Livia S. Carvalho

Publikováno v: eNeuro
eNeuro 6(1), ENEURO.0032-19.2019 (2019). doi:10.1523/ENEURO.0032-19.2019

Mutations in theKCNV2gene, which encodes the voltage-gated K+channel protein Kv8.2, cause a distinctive form of cone dystrophy with a supernormal rod response (CDSRR). Kv8.2 channel subunits only form functional channels when combined in a heterotetr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dd488f06c947a9fb98618936ab8a9b
http://europepmc.org/articles/PMC6393689

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Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer's disease mouse model

Autor: Christian Steinhäuser, Peter Bedner, Monika Plescher, Gerald Seifert, Jan N. Hansen, Annett Halle

Publikováno v: Glia 66(7), 1464-1480 (2018). doi:10.1002/glia.23318

Microglia, the central nervous system resident innate immune cells, cluster around Aβ plaques in Alzheimer's disease (AD). The activation phenotype of these plaque-associated microglial cells, and their differences to microglia distant to Aβ plaque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0878bbd2890adcd02fe378cc02bf0954

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Limited contribution of astroglial gap junction coupling to buffering of extracellular K+ in CA1 stratum radiatum

Autor: Steffen Kautzmann, Anne Boehlen, Christian Henneberger, Christian Steinhäuser, Björn Breithausen

Publikováno v: Glia 68(5), 918-931 (2019). doi:10.1002/glia.23751

Astrocytes form large networks, in which individual cells are connected via gap junctions. It is thought that this astroglial gap junction coupling contributes to the buffering of extracellular K+ increases. However, it is largely unknown how the con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af3b715b32b7680e9be4af85e37d222
https://pub.dzne.de/record/141697

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Potassium channel-based optogenetic silencing

Autor: Wolfgang Bönigk, Sylvain Moser, Silvia Oldani, Heinz Beck, Franziska Schneider-Warme, Dietmar Schmitz, Martin Pofahl, Prateep Beed, Herwig Baier, Dominik Holtkamp, António M. Fernandes, Nicola Masala, Reinhard Seifert, Peter Kohl, Yinth Andrea Bernal Sierra, Peter Hegemann, John J. Tukker, Ramona A. Kopton, Benjamin R. Rost

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications 9(1), 4611 (2018). doi:10.1038/s41467-018-07038-8

Optogenetics enables manipulation of biological processes with light at high spatio-temporal resolution to control the behavior of cells, networks, or even whole animals. In contrast to the performance of excitatory rhodopsins, the effectiveness of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350803fd679d511f6260258bdf231106
https://hdl.handle.net/21.11116/0000-0003-5013-D21.11116/0000-0003-5015-B

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Disentangling astroglial physiology with a realistic cell model in silico

Autor: Savtchenko, Leonid P., Bard, Lucie, Jensen, Thomas P., Reynolds, James P., Kraev, Igor, Medvedev, Nikolay, Stewart, Michael G., Henneberger, Christian, Rusakov, Dmitri A.

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications 9(1), 3554 (2018). doi:10.1038/s41467-018-05896-w

Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying machinery remains enigmatic, mainly because the sponge-like astroc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9f9b717c155df985308fb7b6adcea2dc
http://europepmc.org/articles/PMC6120909

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Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia

Autor: Martin Biel, Mathias W. Seeliger, Sabrina Asteriti, Christian Schön, Vithiyanjali Sothilingam, Jochen Herms, Stylianos Michalakis, Naoyuki Tanimoto, Susanne Koch, Marina Garcia Garrido, Lorenzo Cangiano

Publikováno v: Human molecular genetics 25(6), 1165-1175 (2016). doi:10.1093/hmg/ddv639

Most inherited blinding diseases are characterized by compromised retinal function and progressive degeneration of photoreceptors. However, the factors that affect the life span of photoreceptors in such degenerative retinal diseases are rather poorl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8f8c6b1faf1e1bcaeeee5f0b4e42b7
https://doi.org/10.1093/hmg/ddv639

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Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation

Autor: Nicolas Singewald, Christine Strippel, Ludmila Sosulina, Maren D. Lange, Tatyana Kanyshkova, Simone B. Sartori, Achim Leonhard Walter, Hans-Christian Pape, Hector Romo-Parra

Publikováno v: Journal of neurophysiology 114(4), 2500-2508 (2015). doi:10.1152/jn.00883.2014

Substance P (SP) is implicated in stress regulation and affective and anxiety-related behavior. Particularly high expression has been found in the main output region of the amygdala complex, the central amygdala (CE). Here we investigated the cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b533d7934f923f15e53238f279a6beae
https://doi.org/10.1152/jn.00883.2014

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Immunocytochemical Localization of TASK-3 Protein (K2P9.1) in the Rat Brain

Autor: Harald Prüss, Christiane Marinc, Rüdiger W. Veh, Christian Derst

Publikováno v: Cellular and molecular neurobiology 34(1), 61-70 (2013). doi:10.1007/s10571-013-9987-7

Among all K2P channels, TASK-3 shows the most widespread expression in rat brain, regulating neuronal excitability and transmitter release. Using a recently purified and characterized polyclonal monospecific antibody against TASK-3, the entire rat br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c0c635f3293756a64650bbb3701ba2
https://doi.org/10.1007/s10571-013-9987-7

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