Zobrazeno 1 - 10
of 19
pro vyhledávání: '"metabolism [Neurites]"'
Autor:
Anja Staab, Veronica Villeri, Kristina Desch, Erin M. Schuman, Claudia M Fusco, Julian David Langer, Ivy C. W. Chan, Aline Ricarda Dörrbaum, Mantian Wang, Eleanor Vail
Publikováno v:
Nature Communications 12(1), 6127 (2021). doi:10.1038/s41467-021-26365-x
Nat. Commun.
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications (Nat Commun)
Nat. Commun.
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications (Nat Commun)
Owing to their morphological complexity and dense network connections, neurons modify their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue enriched for dendrites and axons). Although ribosome biogenesis largely takes pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f206c9f7b50af8d77a0776937533f806
https://pub.dzne.de/record/162680
https://pub.dzne.de/record/162680
Autor:
Johanna Tüshaus, Hung-En Hsia, Wolfgang Wurst, Xiao Feng, Stefan F. Lichtenthaler, Benedikt Wefers, Laura I Hofmann, Denise K. Marciano
Publikováno v:
The FASEB journal 35(9), e21813 (2021). doi:10.1096/fj.202100475R
FASEB J. 35:e21813 (2021)
FASEB J. 35:e21813 (2021)
Cell adhesion is tightly controlled in multicellular organisms, for example, through proteolytic ectodomain shedding of the adhesion-mediating cell surface transmembrane proteins. In the brain, shedding of cell adhesion proteins is required for nervo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb52c5f81af11ec46e13c8659da062d
https://pub.dzne.de/record/162810
https://pub.dzne.de/record/162810
Autor:
Gregor Eichele, Andre Fischer, Xunlei Zhou, Haifang Wang, Christina Thaller, Eva Benito, Jun Yan, M. Sadman Sakib, Cemil Kerimoglu, Inga Urban
Publikováno v:
Scientific Reports
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency
Autor:
Bert Klebl, Martin Stehling, Lara Marrone, Peter Nussbaumer, Masin Abo-Rady, Antje Janosch, Jan Eickhoff, Matthias Baumann, Eric N. Anderson, Guruchandar Arulmozhivarman, Gunther Zischinsky, Kenjiro Adachi, Sascha Menninger, Marc Bickle, Peter Reinhardt, Claudia Fröb, Hannes C.A. Drexler, Michell M. Reimer, Jared Sterneckert, Michael Glatza, Susanne Kordes, Prabesh Bhattarai, Udai Bhan Pandey, Caghan Kizil, Lydia Reinhardt, Hans R. Schöler
Publikováno v:
Stem Cell Reports
Stem cell reports 12(3), 502-517 (2019). doi:10.1016/j.stemcr.2019.01.015
Stem Cell Reports, Vol 12, Iss 3, Pp 502-517 (2019)
Stem cell reports 12(3), 502-517 (2019). doi:10.1016/j.stemcr.2019.01.015
Stem Cell Reports, Vol 12, Iss 3, Pp 502-517 (2019)
Summary Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem cell-based phenotypic screening and identified small molecules that directly protected neur
Autor:
Ferrari, María E, Bernis, María E, McLeod, Faye, Podpolny, Marina, Coullery, Romina P, Casadei, Inelia M, Salinas, Patricia C, Rosso, Silvana B
Publikováno v:
Journal of cell science 131(13), jcs216101 (2018). doi:10.1242/jcs.216101
The formation of complex dendritic arbors is crucial for the assembly of functional networks as abnormal dendrite formation underlies several neurodevelopmental and psychiatric disorders. Many extracellular factors have been postulated as regulators
Autor:
Eckhard Mandelkow, Senthilvelrajan Kaniyappan, Eva-Maria Mandelkow, Varunvenkatesh Balaji, Yipeng Wang
Publikováno v:
Autophagy 14(12), 15548627.2018.1509607 (2018). doi:10.1080/15548627.2018.1509607
Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate. Here we investigated the sorting mechanisms of endogenous MAPT in mature primary neurons using mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e978d6ef52d50b033c660d1c53f0be
https://pub.dzne.de/record/140277
https://pub.dzne.de/record/140277
Autor:
Ludger Schöls, Stephan Gierer, Stephan Züchner, Claudia Schulte, Matthis Synofzik, Rebecca Schüle, Dietmar Rudolf Thal
Publikováno v:
International Journal of Molecular Sciences
International journal of molecular sciences 16(10), 25050-25066 (2015). doi:10.3390/ijms161025050
Volume 16
Issue 10
Pages 25050-25066
International Journal of Molecular Sciences, Vol 16, Iss 10, Pp 25050-25066 (2015)
International journal of molecular sciences 16(10), 25050-25066 (2015). doi:10.3390/ijms161025050
Volume 16
Issue 10
Pages 25050-25066
International Journal of Molecular Sciences, Vol 16, Iss 10, Pp 25050-25066 (2015)
Mutations in the SPG7 gene are the most frequent cause of autosomal recessive hereditary spastic paraplegias and spastic ataxias. Ala510Val is the most common SPG7 mutation, with a frequency of up to 1% in the general population. Here we report the c
Autor:
Scherazad Kootar, Marc Aurel Busche, Steven Moore, Lewis D. B. Evans, Sabina Tahirovic, Daniel Hornburg, Dietmar Rudolf Thal, Anna Daria, Hélène Marie, Jochen Herms, Frederick J. Livesey, Christian Haass, Elisabeth Kremmer, Vilmantas Giedraitis, Felix Meissner, Heike Hampel, Veronika Müller, Ulrike Müller, Michael Willem, Camilla Giudici, Saak V. Ovsepian, Michael T. Heneka, Brigitte Nuscher, Lars Lannfelt, Andrea Wenninger-Weinzierl, Arthur Konnerth, Magda Chafai
Publikováno v:
Nature
Nature, Nature Publishing Group, 2015, 526 (7573), pp.443-447. ⟨10.1038/nature14864⟩
Nature 526(7573), 443-447 (2015). doi:10.1038/nature14864
Nature, Nature Publishing Group, 2015, 526 (7573), pp.443-447. ⟨10.1038/nature14864⟩
Nature
Alzheimer's disease (AD) is characterized by the accumulation of amyloid plaques, which are predominantly composed of amyloid β-peptide (Aβ)1. Two principal physiological pathways either prevent or promote Aβ generation from its precursor (amyloid
Autor:
Karina Häbig, Thomas Hentrich, Birgit Heim, Florian Giesert, Carolin Walter, Olaf Riess, Michael Bonin, Wolfgang Wurst, Sandra Gellhaar, Verena Djuric
Publikováno v:
Biochimica et biophysica acta / Molecular basis of disease 1832(12), 2352-2367 (2013). doi:10.1016/j.bbadis.2013.09.009
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common genetic cause of Parkinson's disease (PD). However, LRRK2 function and molecular mechanisms causing the parkinsonian phenotype remain widely unknown. Most of LRRK2 k
Autor:
Natalia Ronkina, Natalya Gorinski, Fabrizia Cesca, Volodimir Cherkas, Gaga Kochlamazashvili, Tatiana Kuznetsova, Matthias Gaestel, Alexander Dityatev, Evgeni Ponimaskin, Juri Lafera, Dalia Abdel Galil, Patricia Marie-Jeanne Lievens
Publikováno v:
Molecular and cellular biology 36(17), 2208-2225 (2016). doi:10.1128/MCB.00144-16
The neural cell adhesion molecule (NCAM) mediates cell-cell and cell-matrix adhesion. It is broadly expressed in the nervous system and regulates neurite outgrowth, synaptogenesis, and synaptic plasticity. Previous in vitro studies revealed that palm