Zobrazeno 1 - 5
of 5
pro vyhledávání: '"metabolism [Neuregulin-1]"'
Autor:
Michael Willem, Sabyashachi Mishra, Amedeo Caflisch, Lawrence Rajendran, Philipp Koch, Kai Simons, Christian Haass, Antonio Baici, Oliver Brüstle, Saoussen Ben Halima, K. Muruga Poopathi Raja
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2127-2141 (2016)
Cell reports 14(9), 2127-2141 (2016). doi:10.1016/j.celrep.2016.01.076
Cell Reports
Cell reports 14(9), 2127-2141 (2016). doi:10.1016/j.celrep.2016.01.076
Cell Reports
SummaryDevelopment of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb3e28d2c3a9a75894ba5236b4ddb35
http://www.sciencedirect.com/science/article/pii/S2211124716300754
http://www.sciencedirect.com/science/article/pii/S2211124716300754
Autor:
Daniel Fleck, Camilla Giudici, Matthias Voss, Michael Willem, Dieter Edbauer, Elisabeth Kremmer, Moritz J. Rossner, Martina Haug-Kröper, Akio Fukumori, Christian Haass, Harald Steiner, Ben Brankatschk, Benjamin M. Schwenk, Regina Fluhrer, Heike Hampel
Publikováno v:
The journal of biological chemistry 291(1), 318-333 (2015). doi:10.1074/jbc.M115.697995
J. Biol. Chem. 291, 318-333 (2016)
J. Biol. Chem. 291, 318-333 (2016)
Numerous membrane-bound proteins undergo regulated intramembrane proteolysis. Regulated intramembrane proteolysis is initiated by shedding, and the remaining stubs are further processed by intramembrane-cleaving proteases (I-CLiPs). Neuregulin 1 type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35971ce3c86b99465f7c5da97b1b0cb9
https://doi.org/10.1074/jbc.m115.697995
https://doi.org/10.1074/jbc.m115.697995
Autor:
Viktorija Velanac, Michael W. Sereda, Ruth M. Stassart, Dies Meijer, Markus H. Schwab, Bastian G. Brinkmann, Klaus-Armin Nave, Robert Fledrich
Publikováno v:
Nature Neuroscience; Vol 16
Nature reviews / Neuroscience 16(1), 48-54 (2012). doi:10.1038/nn.3281
Nature Neuroscience, 16(1), 48-U76. Nature Publishing Group
Nature reviews / Neuroscience 16(1), 48-54 (2012). doi:10.1038/nn.3281
Nature Neuroscience, 16(1), 48-U76. Nature Publishing Group
After peripheral nerve injury, axons regenerate and become remyelinated by resident Schwann cells. However, myelin repair never results in the original myelin thickness, suggesting insufficient stimulation by neuronal growth factors. Upon testing thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0176cddab12324d400af0426f4e98db9
Autor:
Wolfgang H. Oertel, Matthias Höllerhage, Oscar Arias-Carrión, Thomas W. Rösler, Candan Depboylu, Günter U. Höglinger, Thomas Carlsson, André Schrattenholz, Wojciech Wozny
Publikováno v:
Neuropharmacology 61(8), 1413-1418 (2011). doi:10.1016/j.neuropharm.2011.08.033
Neuregulin-1 (NRG1) belongs to a large family of growth and differentiation factors with a key role in the development and maintenance of the brain. Genetic association of NRG1 within brain disorders such as Alzheimer's disease, schizophrenia and neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e4c61bbf293946bcdfcd3ced8981ec
https://doi.org/10.1016/j.neuropharm.2011.08.033
https://doi.org/10.1016/j.neuropharm.2011.08.033
Autor:
Viktorija Velanac, Tobias M. Fischer, Wilko Hinrichs, Veronica Brivio, Maike N. Gummert, Klaus-Armin Nave, Amelia Trimarco, Wiebke Möbius, Tilmann Unterbarnscheidt, Carla Taveggia, Moritz J. Rossner, Markus H. Schwab, Christian Haass, Michael Willem
Publikováno v:
Glia
Glia; Vol 60
Glia 60(2), 203-217 (2011). doi:10.1002/glia.21255
Glia; Vol 60
Glia 60(2), 203-217 (2011). doi:10.1002/glia.21255
Myelin sheath thickness is precisely adjusted to axon caliber, and in the peripheral nervous system, neuregulin 1 (NRG1) type III is a key regulator of this process. It has been proposed that the protease BACE1 activates NRG1 dependent myelination. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c826df07eb95041e13d2438451d9846e
https://hdl.handle.net/11858/00-001M-0000-002A-4BB0-C11858/00-001M-0000-002A-4BAE-3
https://hdl.handle.net/11858/00-001M-0000-002A-4BB0-C11858/00-001M-0000-002A-4BAE-3
