An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion

Autor: Maria-Sophia Vidali, Louis Boon, Aggelos Banos, Aikaterini Termentzi, Triantafyllos Chavakis, Maren Köhne, Panayotis Verginis, Vasiliki Koliaraki, Aikaterini Hatzioannou, Dimitrios T. Boumpas, Constantinos Fedonidis, Marc Beyer, Theodore Sakelaropoulos, Jerome Zoidakis, Ana Henriques, Panagiotis Georgiadis, Aristotelis Tsirigos, Kristian Händler

Publikováno v: Nature immunology 21(1), 75-85 (2019). doi:10.1038/s41590-019-0555-2
Nature Immunology

Regulatory T (Treg) cells accumulate into tumors, hindering the success of cancer immunotherapy. Yet, therapeutic targeting of Treg cells shows limited efficacy or leads to autoimmunity. The molecular mechanisms that guide Treg cell stability in tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70d380d6225eaba62f8d7af1d3ceb1e
https://doi.org/10.1038/s41590-019-0555-2

Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons

Autor: Chiara R, Battaglia, Silvia, Cursano, Enrico, Calzia, Alberto, Catanese, Tobias M, Boeckers

Publikováno v: Cell death & disease 11(11), 1004 (2020). doi:10.1038/s41419-020-03204-3
Cell Death and Disease, Vol 11, Iss 11, Pp 1-19 (2020)
Cell Death & Disease

Neuronal stress-adaptation combines multiple molecular responses. We have previously reported that thorax trauma induces a transient loss of hippocampal excitatory synapses mediated by the local release of the stress-related hormone corticotropin-rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d0b3ac9b2e526ac5b179d0b5792ad069

A protein quality control pathway regulated by linear ubiquitination

Autor: Christian Behl, Christian Haass, Petra Goldmann, Nikolas Furthmann, Jens Meschede, Konstanze F. Winklhofer, Alina Blusch, Dietrich Trümbach, Kohji Mori, Mark S. Hipp, Cathrin Schnack, Wolfgang Wurst, Verian Bader, Jörg Tatzelt, Joseph Longworth, Cathrin Showkat, Elisabeth Petrasch-Parwez, Maria Patra, Carsten Saft, Thomas Arzberger, Dominik A. Sehr, Albrecht M. Clement, Lena A. Berlemann, Lena Angersbach, F. Ulrich Hartl, Ana Sánchez-Vicente, Andreas C. Woerner, Gisa Ellrichmann, Eva M van Well, Ralf Gold, Gunnar Dittmar

Publikováno v: The EMBO journal 38(9), e100730 (2019). doi:10.15252/embj.2018100730

Neurodegenerative diseases are characterized by the accumulation of misfolded proteins in the brain. Insights into protein quality control mechanisms to prevent neuronal dysfunction and cell death are crucial in developing causal therapies. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9026497cb3304040f80c960a7bcdd512
https://pub.dzne.de/record/140707

TBK1 mutation spectrum in an extended European patient cohort with frontotemporal dementia and amyotrophic lateral sclerosis

Autor: Isabel Santana, Estrella Gómez-Tortosa, Federica Perrone, Patrick Cras, Alexandre de Mendonça, Jonathan Baets, Panagiotis Alexopoulos, Peter De Jonghe, Alessandro Padovani, Giovanni B. Frisoni, Frederico Simões do Couto, Håkan Thonberg, Philip Van Damme, Silvia Testi, Peter Paul De Deyn, Roberta Ghidoni, Matthew J. Fraidakis, Marc Bruyland, Maria Rosário Almeida, Alex Michotte, Jordi Clarimón, Agustín Ruiz, Jean Delbeck, Ilse Gijselinck, Jennifer Just, Olivier Deryck, Raquel Sánchez-Valle, Wim Robberecht, Matthis Synofzik, Giuliano Binetti, Adrian Ivanoiu, Sara Ortega-Cubero, Rik Vandenberghe, Isabel Hernández, Walter Maetzler, Ludger Schöls, Robert Perneczky, Kristel Sleegers, Ellen Gelpi, Alberto Lleó, Christine Van Broeckhoven, Julie van der Zee, Mercè Boada, Lubina Dillen, Eric Salmon, Marc Cruts, Patrick Santens, Sebastiaan Engelborghs, Janine Diehl-Schmid, Albert Lladó, Gian Maria Fabrizi, Radoslav Matej, Silvia Bagnoli, Pau Pastor, Frank Jessen, Barbara Borroni, Dirk Nuytten, Adrian Danek, Jan Versijpt, Bavo Heeman, Stayko Sarafov, Caroline Graff, Benedetta Nacmias, Luisa Benussi, Bart Dermaut, Johan Goeman, Michael T. Heneka, Katrien Smets, Gabor G. Kovacs, Christiana Willems, Sara Van Mossevelde, Albena Jordanova, Jan De Bleecker, Ricardo Rojas-García, Alfredo Ramirez, Bruno Bergmans, Ivailo Tournev, Veerle Bäumer, Gabriel Miltenberger-Miltenyi, Sandro Sorbi

Publikováno v: Human Mutation, Vol. 38, No 3 (2017) pp. 297-309
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
HUMAN MUTATION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Instituto de Salud Carlos III (ISCIII)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Human Mutation
Human mutation
Human mutation 38(3), 297-309 (2017). doi:10.1002/humu.23161

© 2016 The Authors. **Human Mutation published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109e18977c1b5c191638868beaace792
http://hdl.handle.net/10044/1/45933

Pitx3 Is a Critical Mediator of GDNF-Induced BDNF Expression in Nigrostriatal Dopaminergic Neurons

Autor: Meng Li, Rüdiger Klein, Changgeng Peng, Wolfgang Wurst, Nilima Prakash, Liviu Aron, Weidong Le

Publikováno v: J. Neurosci. 31, 12802-12815 (2011)
The journal of neuroscience 31(36), 12802-12815 (2011). doi:10.1523/JNEUROSCI.0898-11.2011
Journal of Neuroscience

Pitx3 is a critical homeodomain transcription factor for the proper development and survival of mesodiencephalic dopaminergic (mdDA) neurons in mammals. Several variants of this gene have been associated with human Parkinson's disease (PD), and lack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545f96db56ede28fba08ba1fcb6293d2
https://doi.org/10.1523/jneurosci.0898-11.2011