Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain

Autor: Stanislav Vinopal, Sebastian Dupraz, Eissa Alfadil, Thorben Pietralla, Shweta Bendre, Michael Stiess, Sven Falk, Germán Camargo Ortega, Nicola Maghelli, Iva M. Tolić, Jiří Smejkal, Magdalena Götz, Frank Bradke

Publikováno v: Neuron, 111 (8)
Neuron 111(8), 1241-1263.e16 (2023). doi:10.1016/j.neuron.2023.01.020

Cortical projection neurons polarize and form an axon while migrating radially. Even though these dynamic processes are closely interwoven, they are regulated separately-the neurons terminate their migration when reaching their destination, the corti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb203a2f8b117becb08dc173164d529
https://doi.org/10.1016/j.neuron.2023.01.020

Phase separation of the microtubule-associated protein tau

Autor: Pijush Chakraborty, Markus Zweckstetter

Publikováno v: Essays in Biochemistry
Essays in biochemistry 66(7), 1013-1021 (2022). doi:10.1042/EBC20220066

The aggregation and misfolding of the neuronal microtubule-associated protein tau is closely linked to the pathology of Alzheimer’s disease and several other neurodegenerative diseases. Recent evidence suggest that tau undergoes liquid–liquid pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2392a1722152b7fa47705c639d735d6e
https://hdl.handle.net/21.11116/0000-000C-7395-A21.11116/0000-000C-7397-8

Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2

Autor: Ranjan K. Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Störmer, Felix von Zweydorf, Thomas Dal Maso, Asmaa Oun, Laura Van Rillaer, Sven H. Schmidt, Deep Chatterjee, Joshua A. David, Els Pardon, Thomas U. Schwartz, Stefan Knapp, Eileen J. Kennedy, Jan Steyaert, Friedrich W. Herberg, Arjan Kortholt, Christian Johannes Gloeckner, Wim Versées

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 119(9):e2112712119. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America 119(9), e2112712119 (2022). doi:10.1073/pnas.2112712119

Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson's disease (PD), while LRRK2 overactivation is also associated with the more common idiopathic form of PD. LRRK2 is a large mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec9137a034b6629ae019cb5b5d3957f
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98457

The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure

Autor: Adriana Savastano, Adam G. Hendricks, Markus Zweckstetter, Alisa Cario, Z. Liu, Christopher L. Berger, Neil B. Wood, Michael J. Previs

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America 119(7), e2114215119 (2022). doi:10.1073/pnas.2114215119

The microtubule-associated protein (MAP) Tau is an intrinsically disordered protein (IDP) primarily expressed in axons, where it functions to regulate microtubule dynamics, modulate motor protein motility, and participate in signaling cascades. Tau m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15064374896c20d2c164af1747b0ba20

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment

Autor: Ram Reddy Chandupatla, Eckhard Mandelkow, Yipeng Wang, Bikash Choudhary, Senthilvelrajan Kaniyappan, Ghulam Jeelani Pir, Eva-Maria Mandelkow

Publikováno v: Molecular Neurobiology
Molecular neurobiology 56(5), 3751-3767 (2018). doi:10.1007/s12035-018-1326-z

Tau aggregation is a hallmark of a group of neurodegenerative diseases termed Tauopathies. Reduction of aggregation-prone Tau has emerged as a promising therapeutic approach. Here, we show that an anti-aggregant Tau fragment (F3ΔKPP, residues 258–

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456ee7231425e1779db0fd000c904338
https://doi.org/10.1007/s12035-018-1326-z