Zobrazeno 1 - 10
of 24
pro vyhledávání: '"metabolism [Microtubule-Associated Proteins]"'
Autor:
Thomas Arzberger, Pan Gao, Günter U. Höglinger, Matthias Höllerhage, Thomas Koeglsperger, Qilin Tang, Jochen Herms
Publikováno v:
Cell Death & Disease
Cell death & disease 12(10), 854 (2021). doi:10.1038/s41419-021-04138-0
Cell Death and Disease, Vol 12, Iss 10, Pp 1-16 (2021)
Cell death & disease 12(10), 854 (2021). doi:10.1038/s41419-021-04138-0
Cell Death and Disease, Vol 12, Iss 10, Pp 1-16 (2021)
Dopaminergic (DA) cell death in Parkinson’s disease (PD) is associated with the gradual appearance of neuronal protein aggregates termed Lewy bodies (LBs) that are comprised of vesicular membrane structures and dysmorphic organelles in conjunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4282b753f88fbab0c9a47930649c55a
http://europepmc.org/articles/PMC8448865
http://europepmc.org/articles/PMC8448865
Autor:
Günter U. Höglinger, Wolfgang Wurst, Matthias Höllerhage, Natascha Fussi, Christian Behrends, Thomas W. Rösler
Publikováno v:
Neuropharmacology 149, 13-26 (2019). doi:10.1016/j.neuropharm.2019.01.023
Pathological aggregates of alpha-synuclein are the common hallmarks of synucleinopathies, including Parkinson's disease. There is currently no disease-modifying therapy approved for neurodegenerative synucleinopathies. The induction of macroautophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e929d4d566ceb29c99157505daf15
https://doi.org/10.1016/j.neuropharm.2019.01.023
https://doi.org/10.1016/j.neuropharm.2019.01.023
Autor:
Laura Strohm, Zehan Hu, Yongwon Suk, Alina Rühmkorf, Erin Sternburg, Vanessa Gattringer, Henrick Riemenschneider, Riccardo Berutti, Elisabeth Graf, Jochen H Weishaupt, Monika S Brill, Angelika B Harbauer, Dorothee Dormann, Jörn Dengjel, Dieter Edbauer, Christian Behrends
Publikováno v:
Life science alliance 5(11), e202101327 (2022). doi:10.26508/lsa.202101327
Ubiquilin-2 (UBQLN2) is a ubiquitin-binding protein that shuttles ubiquitinated proteins to proteasomal and autophagic degradation. UBQLN2 mutations are genetically linked to the neurodegenerative disorders amyotrophic lateral sclerosis and frontotem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999c052f873cd378aead73b0b3b1e8b6
https://doi.org/10.26508/lsa.202101327
https://doi.org/10.26508/lsa.202101327
Autor:
Malene Ringkjøbing Jensen, Rostislav Skrabana, Subhash Narasimhan, Kateřina Melková, Lukáš Žídek, Markus Zweckstetter, Vojtěch Zapletal, Martin Blackledge, Jozef Hritz, Séverine Jansen
Publikováno v:
Biomolecules
Biomolecules, MDPI, 2019, 9 (3), pp.105. ⟨10.3390/biom9030105⟩
Biomolecules 9(3), 105 (2019). doi:10.3390/biom9030105
Biomolecules, 2019, 9 (3), pp.105. ⟨10.3390/biom9030105⟩
Biomolecules, Vol 9, Iss 3, p 105 (2019)
Biomolecules, MDPI, 2019, 9 (3), pp.105. ⟨10.3390/biom9030105⟩
Biomolecules 9(3), 105 (2019). doi:10.3390/biom9030105
Biomolecules, 2019, 9 (3), pp.105. ⟨10.3390/biom9030105⟩
Biomolecules, Vol 9, Iss 3, p 105 (2019)
The stability and dynamics of cytoskeleton in brain nerve cells are regulated by microtubule associated proteins (MAPs), tau and MAP2. Both proteins are intrinsically disordered and involved in multiple molecular interactions important for normal phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ce6f56ea1f06603272c2b4a1083981
https://hdl.handle.net/21.11116/0000-0003-3553-421.11116/0000-0003-3555-221.11116/0000-0003-3556-1
https://hdl.handle.net/21.11116/0000-0003-3553-421.11116/0000-0003-3555-221.11116/0000-0003-3556-1
Autor:
Julie A. Mattison, Nigel H. Greig, Hyo Youl Moon, Henriette van Praag, Susan T. Lubejko, Nirnath Sah, Galit Benoni, David Berron, Benjamin Becker, Emma Janke, Emrah Düzel, Andreas Becke
Publikováno v:
Cell metabolism 24(2), 332-340 (2016). doi:10.1016/j.cmet.2016.05.025
Peripheral processes that mediate beneficial effects of exercise on the brain remain sparsely explored. Here, we show that a muscle secretory factor, cathepsin B (CTSB) protein, is important for the cognitive and neurogenic benefits of running. Prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063955dbc25a1d8f9658a24b4d0ee1c4
https://doi.org/10.1016/j.cmet.2016.05.025
https://doi.org/10.1016/j.cmet.2016.05.025
Autor:
Martin Blackledge, Jozef Hritz, Vojtěch Zapletal, Séverine Jansen, Markus Zweckstetter, Malene Ringkjøbing Jensen, Jiří Nováček, Kateřina Melková, Erik Nomilner, Milan Zachrdla, Lukáš Žídek
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (34), pp.13297-13309. ⟨10.1074/jbc.RA118.001769⟩
Journal of Biological Chemistry, 2018, 293 (34), pp.13297-13309. ⟨10.1074/jbc.RA118.001769⟩
The journal of biological chemistry 293(34), 13297-13309 (2018). doi:10.1074/jbc.RA118.001769
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (34), pp.13297-13309. ⟨10.1074/jbc.RA118.001769⟩
Journal of Biological Chemistry, 2018, 293 (34), pp.13297-13309. ⟨10.1074/jbc.RA118.001769⟩
The journal of biological chemistry 293(34), 13297-13309 (2018). doi:10.1074/jbc.RA118.001769
International audience; Microtubule-associated protein 2c (MAP2c) is a 49-kDa intrinsically disordered protein regulating the dynamics of microtubules in developing neurons. MAP2c differs from its sequence homologue Tau in the pattern and kinetics of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09391220f8952424f9ba98cc0852a23a
https://hal.archives-ouvertes.fr/hal-01995909
https://hal.archives-ouvertes.fr/hal-01995909
Autor:
Judith Gunzelmann, Elmar Schiebel, Diana Rüthnick, Annett Neuner, Wanlu Zhang, Tien-chen Lin, Ursula Jäkle
Publikováno v:
eLife, Vol 7 (2018)
eLife 7, e39932 (2018). doi:10.7554/eLife.39932
eLife 7, e39932 (2018). doi:10.7554/eLife.39932
Stu2/XMAP215/ZYG-9/Dis1/Alp14/Msps/ch-TOG family members in association with with γ-tubulin complexes nucleate microtubules, but we know little about the interplay of these nucleation factors. Here, we show that the budding yeast Stu2 in complex wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2710c9e0f0a80ae68016b45784b09e0
https://pubmed.ncbi.nlm.nih.gov/30222109
https://pubmed.ncbi.nlm.nih.gov/30222109
Autor:
Jürgen Goldschmidt, Patrick O. Kanold, Julia U. Henschke, Anja M. Oelschlegel, Frank Angenstein, Frank W. Ohl, Eike Budinger
Publikováno v:
Brain structure & function 223(3), 1165 – 1190 (2017). doi:10.1007/s00429-017-1549-1
The nervous system integrates information from multiple senses. This multisensory integration already occurs in primary sensory cortices via direct thalamocortical and corticocortical connections across modalities. In humans, sensory loss from birth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb5bfa08b46926b130f20c64398c56c
Autor:
Wolfgang H. Oertel, Bertrand Friguet, Gesine Respondek, Günter U. Höglinger, Matthias Höllerhage, Agathe Tarze, Stefanie Müssner, Mohamed Salama, Christel Depienne, Agnès Rastetter, Anderson de Andrade, Pierre Champy, Elizabeth Sumi Yamada
Publikováno v:
Experimental neurology 253, 113-125 (2014). doi:10.1016/j.expneurol.2013.12.017
Experimental Neurology
Experimental Neurology, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Experimental Neurology, Elsevier, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Web of Science
Experimental Neurology
Experimental Neurology, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Experimental Neurology, Elsevier, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Web of Science
International audience; Both genetic and environmental factors likely contribute to the neuropathology of tauopathies, but it remains unclear how specific genetic backgrounds affect the susceptibility towards environmental toxins. Mutations in the ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d266254b13d0c257ddcb9aa3dafadd08
https://doi.org/10.1016/j.expneurol.2013.12.017
https://doi.org/10.1016/j.expneurol.2013.12.017
Autor:
Alessio Colombo, Orly Reiner, Stefan F. Lichtenthaler, Richard M. Page, Anna Münch, Christian Haass, Thomas Horn, Harald Steiner, Peer-Hendrik Kuhn, Michael Boutros
Publikováno v:
The journal of neuroscience 32(50), 18204-18214 (2012). doi:10.1523/JNEUROSCI.2681-12.2012
Amyloid-β peptide (Aβ) is believed to play a central role in the pathogenesis of Alzheimer's disease. In view of the side effects associated with inhibiting the secretases that produce Aβ, new molecular targets are required to provide alternative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ab346de969936d7be1288ca6ecf29f
https://doi.org/10.1523/jneurosci.2681-12.2012
https://doi.org/10.1523/jneurosci.2681-12.2012