Výsledky vyhledávání - "metabolism [MicroRNAs]"

HIF-1α (Hypoxia-Inducible Factor-1α) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383

Autor: Andreas Schober, Ela Karshovska, Isabelle Baatsch, Rokia Mohibullah, Yuanyuan Wei, Nicole Exner, Claudia Geißler, Pallavi Subramanian, Aamoun Popal, Judit Corbalán Campos

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology 40(3), 583-596 (2020). doi:10.1161/ATVBAHA.119.313290

Objective: Inflammatory activation changes the mitochondrial function of macrophages from oxidative phosphorylation to reactive oxygen species production, which may promote necrotic core formation in atherosclerotic lesions. In hypoxic and cancer cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb446a9070d1fc760c894872cac817e
https://pubmed.ncbi.nlm.nih.gov/31996026

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FOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus

Autor: Madeline Craske, Pavankumar Videm, Viktoria Reimann, Verónica I. Dumit, Oliver Schilling, Ganeshkumar Arumugam, Nils Nebel, Tanja Vogel, Wolfgang R. Hess, Andre Fischer, Alejandro Villarreal, Farahnaz Sananbenesi, Stefan Christopher Weise, Stefanie Heidrich, Rolf Backofen

Publikováno v: Molecular neurobiology 56(7), 5188-5201 (2018). doi:10.1007/s12035-018-1444-7
Molecular Neurobiology

Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fbf8778af84b06d294ed1643f520e6
https://doi.org/10.1007/s12035-018-1444-7

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MicroRNA Expression in the Locus Coeruleus, Entorhinal Cortex, and Hippocampus at Early and Middle Stages of Braak Neurofibrillary Tangle Pathology

Autor: Isidro Ferrer, Waqas Tahir, Pol Andrés-Benito, Franc Llorens, Eulàlia Martí, Belén Ansoleaga, Katrin Thüne, Karina Hernández-Ortega, Inga Zerr

Publikováno v: Journal of molecular neuroscience 63(2), 206-215 (2017). doi:10.1007/s12031-017-0971-4

The present study analyzes by RT-qPCR the expression of microRNA (miRNA)-27a-3p, miRNA-124-3p, miRNA-132-3p, and miRNA-143-3p in the locus coeruleus (LC), entorhinal cortex (EC), CA1 region of the hippocampus (CA1), and dentate gyrus (DG) of middle-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ebb7200653a53be4314def41fda73f
https://doi.org/10.1007/s12031-017-0971-4

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An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Autor: Dube, Umber, Del-Aguila, Jorge L, Gentsch, Jen, Wang, Peter, Weiner, Mike, Wolfsberger, Mary, Xiong, Chengjie, Xu, Xiong, Wang, Fengxian, Network, Dominantly Inherited Alzheimer, Salloway, Stephen, Masters, Colin L, Lee, Jae-Hong, Graff-Radford, Neill R, Chhatwal, Jasmeer P, Bateman, Randall J, Morris, John C, Li, Zeran, Karch, Celeste M, Harari, Oscar, Cruchaga, Carlos, Allegri, Ricardo, Amtashar, Fatima, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William, Budde, John P, Buck, Jill, Buckles, Virginia, Chea, Sochenda, Chrem, Patricio, Chui, Helena, Cinco, Jake, Clifford, Jack, D'Mello, Mirelle, Donahue, Tamara, Douglas, Jane, Jiang, Shan, Edigo, Noelia, Erekin-Taner, Nilufer, Fagan, Anne, Farlow, Marty, Farrar, Angela, Feldman, Howard, Flynn, Gigi, Fox, Nick, Franklin, Erin, Fujii, Hisako, Hsu, Simon, Gant, Cortaiga, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldman, Jill, Gordon, Brian, Gray, Julia, Gurney, Jenny, Hassenstab, Jason, Hirohara, Mie, Ibanez, Laura, Holtzman, David, Hornbeck, Russ, DiBari, Siri Houeland, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jerome, Gina, Jucker, Mathias, Kasuga, Kensaku, Kawarabayashi, Takeshi, Klunk, William, Fernandez, Maria Victoria, Koeppe, Robert, Kuder-Buletta, Elke, Laske, Christoph, Levin, Johannes, Marcus, Daniel, Martins, Ralph, Mason, Neal Scott, Maue-Dreyfus, Denise, McDade, Eric, Montoya, Lucy, Farias, Fabiana, Mori, Hiroshi, Nagamatsu, Akem, Neimeyer, Katie, Noble, James, Norton, Joanne, Perrin, Richard, Raichle, Marc, Ringman, John, Roh, Jee Hoon, Schofield, Peter, Shimada, Hiroyuki, Shiroto, Tomoyo, Shoji, Mikio, Sigurdson, Wendy, Sohrabi, Hamid, Sparks, Paige, Suzuki, Kazushi, Swisher, Laura, Taddei, Kevin, Wang, Jen

Publikováno v: Nature reviews / Neuroscience 22(11), 1903-1912 (2019). doi:10.1038/s41593-019-0501-5
Nature neuroscience

Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and an independent (Mount Sinai

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Reciprocal Regulation between Bifunctional miR-9/9∗ and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation

Autor: Michael Peitz, Bernd O. Evert, Oliver Brüstle, Laura Stappert, Monika Veltel, Lodovica Borghese, Beate Roese-Koerner, Johannes Jungverdorben, Nils Christian Braun, Thomas Berger

Publikováno v: Stem cell reports 7(2), 207-219 (2016). doi:10.1016/j.stemcr.2016.06.008
Stem Cell Reports
Stem Cell Reports, Vol 7, Iss 2, Pp 207-219 (2016)

Summary Tight regulation of the balance between self-renewal and differentiation of neural stem cells is crucial to assure proper neural development. In this context, Notch signaling is a well-known promoter of stemness. In contrast, the bifunctional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56424c3bd471b2487024a5c91230a79a

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The Role of MicroRNAs in Spinocerebellar Ataxia Type 3

Autor: Bernd O. Evert, Sybille Krauss

Publikováno v: Journal of molecular biology 431(9), 1729-1742 (2019). doi:10.1016/j.jmb.2019.01.019

More than 90% of the human genome are transcribed as non-coding RNAs. While it is still under debate if all these non-coding transcripts are functional, there is emerging evidence that RNA has several important functions in addition to coding for pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e63e8d8ca572d13552faaf5d9e8e356
https://pubmed.ncbi.nlm.nih.gov/30664869

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Upregulation of miR-25 and miR-181 Family Members Correlates with Reduced Expression of ATXN3 in Lymphocytes from SCA3 Patients

Autor: Bernd O. Evert, Sybille Krauss, Stephanie Weber, Katlynn Carter, Rohit Nalavade

Publikováno v: MicroRNA 8(1), 76-85 (2018). doi:10.2174/2211536607666180821162403

Background: Spinocerebellar ataxia type 3 (SCA3), the most common spinocerebellar ataxia, is caused by a polyglutamine (polyQ) expansion in the protein ataxin-3 (ATXN3). Silencing the expression of polyQ-expanded ATXN3 rescues the cellular disease ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5ecaf4ba17989f8e6a01f4496a4f01
https://pubmed.ncbi.nlm.nih.gov/30147021

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In silico identification and characterization of a diverse subset of conserved microRNAs in bioenergy crop Arundo donax L

Autor: Giorgio Bertorelle, Claudio Varotto, Gaurav Sablok, Mingai Li, Wuhe Jike

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

MicroRNAs (miRNAs) are small non-coding RNA molecules involved in the post-transcriptional regulation of gene expression in plants. Arundo donax L. is a perennial C3 grass considered one of the most promising bioenergy crops. Despite its relevance, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4af2446a7ddb9ed3fba471662bf43f0
http://hdl.handle.net/11392/2401128

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