Zobrazeno 1 - 10
of 12
pro vyhledávání: '"metabolism [Memory Disorders]"'
Autor:
Chiesa, Patrizia A, Cavedo, Enrica, Initiative, INSIGHT-preAD Study Group and the Alzheimer Precision Medicine, Grothe, Michel J, Houot, Marion, Teipel, Stefan J, Potier, Marie-Claude, Habert, Marie-Odile, Lista, Simone, Dubois, Bruno, Hampel, Harald
Publikováno v:
Radiology 290(1), 167-176 (2019). doi:10.1148/radiol.2018180268
Purpose To evaluate the association between the global fibrillary amyloid-β pathology and the basal forebrain connectivity at rest in cognitively intact older adults at risk for Alzheimer disease. Materials and Methods This retrospective study was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d24d9513d62996e79ef10e188d3d72f
https://doi.org/10.1148/radiol.2018180268
https://doi.org/10.1148/radiol.2018180268
Autor:
Neitzel, Julia, Franzmeier, Nicolai, Petersen, Ronald, Clark, David, Geldmacher, David, Brockington, John, Roberson, Erik, Grossman, Hillel, Mitsis, Effie, deToledo-Morrell, Leyla, Shah, Raj C, Duara, Ranjan, Varon, Daniel, Jack, Clifford R, Greig, Maria T, Roberts, Peggy, Albert, Marilyn, Onyike, Chiadi, D'Agostino, Daniel, Kielb, Stephanie, Galvin, James E, Pogorelec, Dana M, Cerbone, Brittany, Michel, Christina A, Jagust, William, Rusinek, Henry, de Leon, Mony J, Glodzik, Lidia, De Santi, Susan, Doraiswamy, P Murali, Petrella, Jeffrey R, Wong, Terence Z, Arnold, Steven E, Karlawish, Jason H, Wolk, David, Trojanowki, John Q, Smith, Charles D, Jicha, Greg, Hardy, Peter, Sinha, Partha, Oates, Elizabeth, Conrad, Gary, Lopez, Oscar L, Oakley, MaryAnn, Simpson, Donna M, Porsteinsson, Anton P, Toga, Arthur W, Goldstein, Bonnie S, Martin, Kim, Makino, Kelly M, Ismail, Muhammad, Brand, Connie, Mulnard, Ruth A, Thai, Gaby, Mc Adams Ortiz, Catherine, Womack, Kyle, Mathews, Dana, Beckett, Laurel, Quiceno, Mary, Arrastia, Ramon Diaz, King, Richard, Weiner, Myron, Cook, Kristen Martin, DeVous, Michael, Levey, Allan I, Lah, James J, Cellar, Janet S, Burns, Jeffrey M, Green, Robert C, Anderson, Heather S, Swerdlow, Russell H, Apostolova, Liana, Tingus, Kathleen, Woo, Ellen, Silverman, Daniel H S, Lu, Po H, Bartzokis, George, Radford, Neill R Graff, ParfittH, Francine, Saykin, Andrew J, Kendall, Tracy, Johnson, Heather, Farlow, Martin R, Hake, Ann Marie, Matthews, Brandy R, Herring, Scott, Hunt, Cynthia, van Dyck, Christopher H, Carson, Richard E, MacAvoy, Martha G, Morris, John, Chertkow, Howard, Bergman, Howard, Hosein, Chris, Black, Sandra, Stefanovic, Bojana, Caldwell, Curtis, Hsiung, Ging Yuek Robin, Feldman, Howard, Mudge, Benita, Past, Michele Assaly, Shaw, Leslie, Kertesz, Andrew, Rogers, John, Trost, Dick, Bernick, Charles, Munic, Donna, Kerwin, Diana, Mesulam, Marek Marsel, Lipowski, Kristine, Wu, Chuang Kuo, Johnson, Nancy, Rubinski, Anna, Liu, Enchi, Sadowsky, Carl, Martinez, Walter, Villena, Teresa, Turner, Raymond Scott, Johnson, Kathleen, Reynolds, Brigid, Sperling, Reisa A, Johnson, Keith A, Marshall, Gad, Frey, Meghan, Montine, Tom, Yesavage, Jerome, Taylor, Joy L, Lane, Barton, Rosen, Allyson, Tinklenberg, Jared, Sabbagh, Marwan N, Belden, Christine M, Jacobson, Sandra A, Sirrel, Sherye A, Kowall, Neil, Thomas, Ronald G, Killiany, Ronald, Budson, Andrew E, Norbash, Alexander, Johnson, Patricia Lynn, Obisesan, Thomas O, Wolday, Saba, Allard, Joanne, Lerner, Alan, Ogrocki, Paula, Hudson, Leon, Donohue, Michael, Fletcher, Evan, Carmichael, Owen, Olichney, John, DeCarli, Charles, Kittur, Smita, Borrie, Michael, Lee, T. Y., Bartha, Rob, Johnson, Sterling, Asthana, Sanjay, Walter, Sarah, Carlsson, Cynthia M, Potkin, Steven G, Preda, Adrian, Nguyen, Dana, Tariot, Pierre, Reeder, Stephanie, Bates, Vernice, Capote, Horacio, Rainka, Michelle, Scharre, Douglas W, Gessert, Devon, Kataki, Maria, Adeli, Anahita, Zimmerman, Earl A, Celmins, Dzintra, Brown, Alice D, Pearlson, Godfrey D, Blank, Karen, Anderson, Karen, Santulli, Robert B, Kitzmiller, Tamar J, Sather, Tamie, Schwartz, Eben S, SinkS, Kaycee M, Williamson, Jeff D, Garg, Pradeep, Watkins, Franklin, Ott, Brian R, Querfurth, Henry, Tremont, Geoffrey, Salloway, Stephen, Malloy, Paul, Jiminez, Gus, Correia, Stephen, Rosen, Howard J, Miller, Bruce L, Mintzer, Jacobo, Spicer, Kenneth, Bachman, David, Finger, Elizabether, Pasternak, Stephen, Rachinsky, Irina, Drost, Dick, Harvey, Danielle, Pomara, Nunzio, Hernando, Raymundo, Sarrael, Antero, Schultz, Susan K, Ponto, Laura L Boles, Shim, Hyungsub, Smith, Karen Elizabeth, Relkin, Norman, Chaing, Gloria, Raudin, Lisa, Bernstein, Matthew, Smith, Amanda, Fargher, Kristin, Raj, Balebail Ashok, Dichgans, Martin, Fox, Nick, Thompson, Paul, Schuff, Norbert, DeCArli, Charles, Borowski, Bret, Gunter, Jeff, Senjem, Matt, Vemuri, Prashanthi, Jones, David, Kantarci, Kejal, Brendel, Matthias, Ward, Chad, Koeppe, Robert A, Foster, Norm, Reiman, Eric M, Chen, Kewei, Mathis, Chet, Landau, Susan, Cairns, Nigel J, Householder, Erin, Reinwald, Lisa Taylor, Initiative, Alzheimer’s Disease Neuroimaging, Lee, Virginia, Korecka, Magdalena, Figurski, Michal, Crawford, Karen, Neu, Scott, Foroud, Tatiana M, Potkin, Steven, Shen, Li, Kelley, Faber, Kim, Sungeun, Malik, Rainer, Nho, Kwangsik, Kachaturian, Zaven, Frank, Richard, Snyder, Peter J, Molchan, Susan, Kaye, Jeffrey, Quinn, Joseph, Lind, Betty, Carter, Raina, Dolen, Sara, Ewers, Michael, Schneider, Lon S, Pawluczyk, Sonia, Beccera, Mauricio, Teodoro, Liberty, Spann, Bryan M, Brewer, James, Vanderswag, Helen, Fleisher, Adam, Heidebrink, Judith L, Lord, Joanne L, Weiner, Michael, Mason, Sara S, Albers, Colleen S, Knopman, David S, Johnson, Kris, Doody, Rachelle S, Meyer, Javier Villanueva, Chowdhury, Munir, Rountree, Susan, Dang, Mimi, Stern, Yaakov, Aisen, Paul, Honig, Lawrence S, Bell, Karen L, Ances, Beau, Morris, John C, Carroll, Maria, Leon, Sue, Mintun, Mark A, Schneider, Stacy, OliverNG, Angela, Griffith, Randall
Publikováno v:
Nature Communications, 12(1):3825. Nature Publishing Group
Nature Communications
Nature Communications 12(1), 3825 (2021). doi:10.1038/s41467-021-23755-z
Nature Communications
Nature Communications 12(1), 3825 (2021). doi:10.1038/s41467-021-23755-z
Klotho-VS heterozygosity (KL-VShet) is associated with reduced risk of Alzheimer’s disease (AD). However, whether KL-VShet is associated with lower levels of pathologic tau, i.e., the key AD pathology driving neurodegeneration and cognitive decline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ba889c74202405fa0432553523acbc1d
https://pure.eur.nl/en/publications/0347fc8d-115c-42f1-b66c-ef26e0deadd1
https://pure.eur.nl/en/publications/0347fc8d-115c-42f1-b66c-ef26e0deadd1
Autor:
Bernhardt, Nadine, Lieser, Maike Kristin, Hlusicka, Elizabeth-Barroeta, Habelt, Bettina, Wieske, Franziska, Edemann-Callesen, Henriette, Garthe, Alexander, Winter, Christine
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific reports 8(1), 14173 (2018). doi:10.1038/s41598-018-32608-7
Scientific reports 8(1), 14173 (2018). doi:10.1038/s41598-018-32608-7
With its capacity to modulate motor control and motivational as well as cognitive functions dopamine is implicated in numerous neuropsychiatric diseases. The present study investigated whether an imbalance in dopamine homeostasis as evident in the do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6f08cac2dc54aa81bd38ba2f080a8f66
http://link.springer.com/article/10.1038/s41598-018-32608-7
http://link.springer.com/article/10.1038/s41598-018-32608-7
Autor:
Gregor Eichele, Andre Fischer, Xunlei Zhou, Haifang Wang, Christina Thaller, Eva Benito, Jun Yan, M. Sadman Sakib, Cemil Kerimoglu, Inga Urban
Publikováno v:
Scientific Reports
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d444ec66987556cb4c7f6b85293f7171
https://doi.org/10.1038/s41598-019-50927-1
https://doi.org/10.1038/s41598-019-50927-1
Autor:
Stéphane Epelbaum, M. Kilani, S. Cherif Touil, Bruno Dubois, M. Thiebaut, M.C. Potier, G. Dalla Barba, K. Santos-Andrade, R. Schindler, V. Simon, Stéphane Lehéricy, Catherine Poisson, V. Causse, Olga Uspenskaya, Fanny Mochel, H. Hewa, H. Francisque, I. Masetti, Laurie Boukadida, M. Vlaincu, Patrizia A. Chiesa, A. Mendes, Federica Cacciamani, Michael D. Greicius, Michel J. Grothe, Luisa Sambati, Aurélie Kas, A. Genin, F. Gombert, S. Lista, S. Ratovohery, S. Epelbaum, Marie-Claude Potier, B. Fontaine, J. Ly, P. Glasman, G. Gagliardi, Simone Lista, F. Poirier, Marie-Odile Habert, M.O. Habert, Marion Dubois, Stefan J. Teipel, Katrine Rojkova, Habib Benali, Harald Hampel, M. Lowrey, C. Audrain, M.C. Servera, D. Skovronsky, Francis Nyasse, Remy Genthon, Marcel Levy, Marie Revillon, R. Nait Arab, Geoffroy Gagliardi, A. Michon, Nicola Toschi, A. Dos Santos, Marion Houot, V. La Corte, M. Depaulis, Enrica Cavedo, Anne Bertrand, Olivier Colliot, A. Auffret, O. Makiese, C. Perrin, Hovagim Bakardjian, Bénédicte Batrancourt, Hugo Bertin, Filippo Baldacci, L. Seux, Christiane Metzinger, N. Jungalee, C. Letondor, F. Le Roy, I. Benakki
Publikováno v:
Alzheimer's and dementia 14(9), 1126-1136 (2018). doi:10.1016/j.jalz.2018.04.004
Introduction Cognitive change in people at risk of Alzheimer's disease (AD) such as subjective memory complainers is highly variable across individuals. Methods We used latent class growth modeling to identify distinct classes of nonlinear trajectori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82599a2fcd35d8c24934aa5afe71463
http://hdl.handle.net/11368/2941521
http://hdl.handle.net/11368/2941521
Publikováno v:
Translational Psychiatry 7(8), e1185-e1185 (2017). doi:10.1038/tp.2017.149
Translational Psychiatry
Translational Psychiatry
Chemotherapy-induced central nervous system (CNS) neurotoxicity presents an unmet medical need. Patients often report a cognitive decline in temporal correlation to chemotherapy, particularly for hippocampus-dependent verbal and visuo-spatial abiliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33c061604dc75cc83586daf9b6af206
https://pub.dzne.de/record/139420
https://pub.dzne.de/record/139420
Autor:
Antonino Natalello, Marco Rasile, Eliana Lauranzano, Sonia Mazzitelli, Davide Pozzi, Isabella Barajon, Matteo Tamborini, Chiara Starvaggi-Cucuzza, Fabia Filipello, Michela Matteoli, Toni Giorgino
Publikováno v:
Acta Neuropathologica Communications 4(1), 110 (2016). doi:10.1186/s40478-016-0381-9
Acta Neuropathologica Communications
Acta Neuropathologica Communications 4 (2016): 110. doi:10.1186/s40478-016-0381-9
info:cnr-pdr/source/autori:Mazzitelli S.; Filipello F.; Rasile M.; Lauranzano E.; Starvaggi-Cucuzza C.; Tamborini M.; Pozzi D.; Barajon I.; Giorgino T.; Natalello A.; Matteoli M./titolo:Amyloid-beta 1-24 C-terminal truncated fragment promotes amyloid-beta 1-42 aggregate formation in the healthy brain/doi:10.1186%2Fs40478-016-0381-9/rivista:Acta Neuropathologica Communications/anno:2016/pagina_da:110/pagina_a:/intervallo_pagine:110/volume:4
Scopus-Elsevier
Acta Neuropathologica Communications
Acta Neuropathologica Communications 4 (2016): 110. doi:10.1186/s40478-016-0381-9
info:cnr-pdr/source/autori:Mazzitelli S.; Filipello F.; Rasile M.; Lauranzano E.; Starvaggi-Cucuzza C.; Tamborini M.; Pozzi D.; Barajon I.; Giorgino T.; Natalello A.; Matteoli M./titolo:Amyloid-beta 1-24 C-terminal truncated fragment promotes amyloid-beta 1-42 aggregate formation in the healthy brain/doi:10.1186%2Fs40478-016-0381-9/rivista:Acta Neuropathologica Communications/anno:2016/pagina_da:110/pagina_a:/intervallo_pagine:110/volume:4
Scopus-Elsevier
Substantial data indicate that amyloid-? (A?), the major component of senile plaques, plays a central role in Alzheimer's Disease and indeed the assembly of naturally occurring amyloid peptides into cytotoxic aggregates is linked to the disease patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80d64826414d967cfe3253aaab12eab
https://doi.org/10.1186/s40478-016-0381-9
https://doi.org/10.1186/s40478-016-0381-9
Autor:
Bénédicte Oulès, Patrizia Paterlini-Bréchot, Dolores Del Prete, Mounia Chami, Inger Lauritzen, Barbara Greco, Xuexin Zhang, Frédéric Checler, Sébastien Moreno, Mohamed Trebak, Jean Sevalle, Fabio Benfenati
Publikováno v:
The Journal of Neuroscience. 32:11820-11834
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein (APP), thereby generating amy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0c0f6ea578d7ddc16857385cd179e1
https://doi.org/10.1523/jneurosci.0875-12.2012
https://doi.org/10.1523/jneurosci.0875-12.2012
Autor:
Michael T. Heneka, Monika Stoll, Gregor Eichele, Hans-Christian Pape, Markus P. Kummer, Stephanie Schwartz, Joachim L. Schultze, David Weinshenker, Thea Hammerschmidt, Stefanie Figura, Anika Witten, Ana Martinez, Dick Terwel
Publikováno v:
Journal of Neuroscience
The journal of neuroscience 34(26), 8845-8854 (2014). doi:10.1523/JNEUROSCI.4027-13.2014
The journal of neuroscience 34(26), 8845-8854 (2014). doi:10.1523/JNEUROSCI.4027-13.2014
To assess the consequences of locus ceruleus (LC) degeneration and subsequent noradrenaline (NA) deficiency in early Alzheimer’sdisease (AD), mice overexpressing mutant amyloid precursor protein and presenilin-1 (APP/PS1) were crossed with Ear2( /
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07aa351b64b44747d3df90e1ce8bcba3
https://zenodo.org/record/16482
https://zenodo.org/record/16482
Autor:
Wolfgang Maier, Oliver G. Bosch, Frank Jessen, Boris B. Quednow, Erich Seifritz, Kai-Uwe Kühn, Michael Wagner, Alexius Joe, Hans-Jürgen Biersack
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e61234 (2013)
PloS one
PLOS ONE 8(4), e61234 (2013). doi:10.1371/journal.pone.0061234
PLoS ONE, Vol 8, Iss 4, p e61234 (2013)
PloS one
PLOS ONE 8(4), e61234 (2013). doi:10.1371/journal.pone.0061234
INTRODUCTION: 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a recreational club drug with supposed neurotoxic effects selectively on the serotonin system. MDMA users consistently exhibit memory dysfunction but there is an ongoing debate if t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5769c2aecd8992be23339c0cc708b24
https://pubmed.ncbi.nlm.nih.gov/23585882
https://pubmed.ncbi.nlm.nih.gov/23585882