Zobrazeno 1 - 10
of 24
pro vyhledávání: '"metabolism [Lysine]"'
Autor:
S Cantilena, Stefanie Meier, Darren Hargrave, David Michod, John Anderson, Jasper de Boer, Maria Victoria Niklison Chirou, Paolo Salomoni
Publikováno v:
Cell Death & Disease
Cell death & disease 12(8), 785 (2021). doi:10.1038/s41419-021-04078-9
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell death & disease 12(8), 785 (2021). doi:10.1038/s41419-021-04078-9
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Pediatric gliomas comprise a broad range of brain tumors derived from glial cells. While high-grade gliomas are often resistant to therapy and associated with a poor outcome, children with low-grade gliomas face a better prognosis. However, the treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352d109b5f0dbec2fa754da507bbd703
https://pubmed.ncbi.nlm.nih.gov/34381018
https://pubmed.ncbi.nlm.nih.gov/34381018
Autor:
Jorge Garcia Morato, Manuela Neumann, Christian Johannes Gloeckner, Angelos Skodras, Friederike Hans, Simon J Elsaesser, Felix von Zweydorf, Emanuele Buratti, Regina Feederle, Philipp J. Kahle
Publikováno v:
Nature Communications 13(1), 1223 (2022). doi:10.1038/s41467-022-28822-7
Nat. Commun. 13:1223 (2022)
Nat. Commun. 13:1223 (2022)
The trans-activation response DNA-binding protein TDP-43 regulates RNA processing and forms neuropathological aggregates in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Investigating TDP-43 post-translational mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b746aefc39a137a222ef1f6d3b5e41
https://doi.org/10.1101/2020.05.26.104356
https://doi.org/10.1101/2020.05.26.104356
Autor:
Gregor Eichele, Andre Fischer, Xunlei Zhou, Haifang Wang, Christina Thaller, Eva Benito, Jun Yan, M. Sadman Sakib, Cemil Kerimoglu, Inga Urban
Publikováno v:
Scientific Reports
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific reports 9(1), 16173 (2019). doi:10.1038/s41598-019-50927-1
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d444ec66987556cb4c7f6b85293f7171
https://doi.org/10.1038/s41598-019-50927-1
https://doi.org/10.1038/s41598-019-50927-1
Autor:
Mathieu Blanchette, Albert M. Berghuis, Hiromichi Suzuki, Pratiti Bandopadhayay, Dong Anh Khuong-Quang, Dylan M. Marchione, Nicolas De Jay, Wajih Jawhar, Angelia V. Bassenden, Djihad Hadjadj, Ashot S. Harutyunyan, Shriya Deshmukh, Steffen Albrecht, Michele Zeinieh, Nikoleta Juretic, Paolo Salomoni, Katerina Vanova, Ales Vicha, Stefan M. Pfister, Manav Pathania, Selin Jessa, Almos Klekner, Leonie G. Mikael, CM Kramm, David T.W. Jones, Tenzin Gayden, Sebastian Brandner, Michal Zapotocky, Nicola Maestro, Eleanor Woodward, Alexander G. Weil, David S. Ziegler, Jordan R. Hansford, Steven Hébert, Frank Dubois, Benjamin Ellezam, Deli A, Damien Faury, Véronique Lisi, Augusto Faria Andrade, Andrey Korshunov, Mariella G. Filbin, Michael D. Taylor, Claudia L. Kleinman, Andrea Bajic, Carol C.L. Chen, Caterina Russo, Nada Jabado, Peter Hauser, Benjamin A. Garcia, Stephen C. Mack, Keith L. Ligon, David Sumerauer, Lenka Krskova, Jason Karamchandani, Rameen Beroukhim, Rola Dali, László Bognár, Dominik Sturm, József Virga, Marie Coutelier, Livia Garzia, Paul G Ekert, Josef Zamecnik
Publikováno v:
Cell 183(6), 1617-1633.e22 (2020). doi:10.1016/j.cell.2020.11.012
Cell
Cell
Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here, we show that 50% of G34R/V-tumours (n=95) b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a47ac89beefcaff088e65fd3f8a3589
https://doi.org/10.1016/j.cell.2020.11.012
https://doi.org/10.1016/j.cell.2020.11.012
Autor:
Dorothee Dormann, Maria-Sol Cima-Omori, Tina Ukmar-Godec, Saskia Hutten, Eckhard Mandelkow, Jacek Biernat, Nasrollah Rezaei-Ghaleh, Matthew P. Grieshop, Johannes Söding, Markus Zweckstetter
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications 10(1), 2909 (2019). doi:10.1038/s41467-019-10792-y
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications 10(1), 2909 (2019). doi:10.1038/s41467-019-10792-y
Cells form and use biomolecular condensates to execute biochemical reactions. The molecular properties of non-membrane-bound condensates are directly connected to the amino acid content of disordered protein regions. Lysine plays an important role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b801486d8ee6de8474773052015ac0
https://pubmed.ncbi.nlm.nih.gov/31266957
https://pubmed.ncbi.nlm.nih.gov/31266957
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications 8(1), 275 (2017). doi:10.1038/s41467-017-00480-0
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications 8(1), 275 (2017). doi:10.1038/s41467-017-00480-0
The protein Tau aggregates into tangles in the brain of patients with Alzheimer’s disease. In solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules. It is still unclear what initiates the conversion from an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49267a9b5b9f3dae2f03e7157948703
https://hdl.handle.net/11858/00-001M-0000-002D-D0E6-A11858/00-001M-0000-002D-D0E8-6
https://hdl.handle.net/11858/00-001M-0000-002D-D0E6-A11858/00-001M-0000-002D-D0E8-6
Autor:
Michael Brecht, Prateep Beed, Claudia Böhm, Andrea Burgalossi, Anja Gundlfinger, Imre Vida, Dietmar Schmitz, Jie Song, Sophie Schneiderbauer
Publikováno v:
Neuron 79(6), 1197-1207 (2013). doi:10.1016/j.neuron.2013.06.038
SummaryLocal inhibitory microcircuits in the medial entorhinal cortex (MEC) and their role in network activity are little investigated. Using a combination of electrophysiological, optical, and morphological circuit analysis tools, we find that layer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869b8b05b00e6152463987482d60682a
https://doi.org/10.1016/j.neuron.2013.06.038
https://doi.org/10.1016/j.neuron.2013.06.038
Autor:
Naoto Sugeno, Sandra Jäckel, Aaron Voigt, Zinah Wassouf, Julia Schulze-Hentrich, Philipp J. Kahle
Publikováno v:
Scientific reports 6, 36328 (2016). doi:10.1038/srep36328
Scientific Reports
Scientific reports 6(1), 36328 (2016). doi:10.1038/srep36328
Scientific Reports
Scientific reports 6(1), 36328 (2016). doi:10.1038/srep36328
Scientific reports 6(1), 36328 (2016). doi:10.1038/srep36328
Published by Nature Publishing Group, London
Published by Nature Publishing Group, London
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99130c19bb7fa25d8e419b8d57c9a217
Publikováno v:
Scientific Reports
Scientific reports 6(1), 22685 (2016). doi:10.1038/srep22685
Scientific reports 6(1), 22685 (2016). doi:10.1038/srep22685
Dysfunction and accumulation of the microtubule-associated human Tau (hTau) protein into intraneuronal aggregates is observed in many neurodegenerative disorders including Alzheimer’s disease (AD). Reversible lysine acetylation has recently emerged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00241a69b9c48a44170438cbac328189
https://hdl.handle.net/21.11116/0000-000B-7191-1
https://hdl.handle.net/21.11116/0000-000B-7191-1
Autor:
Robert A. Hipskind, Manuel S. Rodriguez, Guillaume Bossis, Rosa Farràs, Elisabetta Andermarcher, Stefan Müller, Marc Piechaczyk, Isabelle Jariel-Encontre, Darja Schmidt, Cécile E. Malnou
Publikováno v:
Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2005, 25 (16), pp.6964--79. ⟨10.1128/MCB.25.16.6964-6979.2005⟩
Molecular and Cellular Biology, American Society for Microbiology, 2005, 25 (16), pp.6964--79. ⟨10.1128/MCB.25.16.6964-6979.2005⟩
The inducible transcriptional complex AP-1, composed of c-Fos and c-Jun proteins, is crucial for cell adaptation to many environmental changes. While its mechanisms of activation have been extensively studied, how its activity is restrained is poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a009d8327ae4e750871e9b3eb0985d58
https://doi.org/10.1128/mcb.25.16.6964-6979.2005
https://doi.org/10.1128/mcb.25.16.6964-6979.2005