Alterations in Blood Monocyte Functions in Parkinson's Disease

Autor: Holger Jon Møller, Claudia Schulte, Daniela Berg, Daniel E. Otzen, Kalpana Shrivastava, Sara K. Nissen, Walter Maetzler, David Goldeck, Marina Romero-Ramos

Publikováno v: Nissen, S K, Shrivastava, K, Schulte, C, Otzen, D E, Goldeck, D, Berg, D, Møller, H J, Maetzler, W & Romero-Ramos, M 2019, ' Alterations in Blood Monocyte Functions in Parkinson's Disease ', Movement Disorders, vol. 34, no. 11, pp. 1711-1721 . https://doi.org/10.1002/mds.27815
Movement disorders 34(11), 1711-1721 (2019). doi:10.1002/mds.27815

BACKGROUND: PD is a multisystem disease where both central and peripheral nervous systems are affected. This systemic involvement also includes the immune response in PD, which implicates not only microglia in the brain, but also peripheral immune ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3472c893711e71c8276085e8e54ed7
https://doi.org/10.1002/mds.27815

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

Autor: Böttcher, C., Fernández-Zapata, C., Schlickeiser, S., Kunkel, D., Schulz, A.R., Mei, H.E., Weidinger, C., Gieß, R.M., Asseyer, S., Siegmund, B., Paul, F., Ruprecht, K., Priller, J.

Publikováno v: Scientific reports 9(1), 19471 (2019). doi:10.1038/s41598-019-55852-x
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports

Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). Studies in rodent models demonstrated an association of CNS-infiltrating monocyte-derived macrophages with disease severity. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc00df5264e9b62af103180cdcc39ab1

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

Autor: Avril A. B. Robertson, Grant R Drummond, Julie L. McAuley, Mark E. Cooper, Jennifer K. Dowling, Michelle D. Tate, James D. H. Ong, Ashley Mansell, Paul J. Hertzog, Eicke Latz

Publikováno v: Scientific Reports
Scientific reports 6(1), 27912 (2016). doi:10.1038/srep27912

The inflammasome NLRP3 is activated by pathogen associated molecular patterns (PAMPs) during infection, including RNA and proteins from influenza A virus (IAV). However, chronic activation by danger associated molecular patterns (DAMPs) can be delete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671eea563517a0d36d49050148633cf7
https://doi.org/10.1038/srep27912

Isolating Peripheral Lymphocytes by Density Gradient Centrifugation and Magnetic Cell Sorting

Autor: Katrin Marcus, Caroline May, Frederic Brosseron

Publikováno v: New York, NY : Springer New York, Methods in Molecular Biology 1295, 33-42 (2015). doi:10.1007/978-1-4939-2550-6_3
Proteomic Profiling / Posch, Anton (Editor) ; New York, NY : Springer New York, 2015, Chapter 3 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-2549-0=978-1-4939-2550-6 ; doi:10.1007/978-1-4939-2550-6
Methods in Molecular Biology ISBN: 9781493925490

Combining density gradient centrifugation with magnetic cell sorting provides a powerful tool to isolate blood cells with high reproducibility, yield, and purity. It also allows for subsequent separation of multiple cell types, resulting in the possi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116a00b21b33312472268f47270926f2

Induction of RET dependent and independent pro-inflammatory programs in human peripheral blood mononuclear cells from Hirschsprung patients

Autor: Ivana Matera, Stefano Avanzini, William J. Pavan, Isabella Ceccherini, Paola Griseri, Alessio Pini-Prato, Francesca Lantieri, Domenico Mavilio, Roberto Ravazzolo, Marta Rusmini, Valentina A. Rossi, Alessandra Roberto, Vincenzo Jasonni, Girolamo Mattioli, Joanna Mikulak, Kelly Hudspeth

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59066 (2013)
PLoS ONE

Hirschsprung disease (HSCR) is a rare congenital anomaly characterized by the absence of enteric ganglia in the distal intestinal tract. While classified as a multigenic disorder, the altered function of the RET tyrosine kinase receptor is responsibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e765b2e5247381e6fdfef264baf60d
http://europepmc.org/articles/PMC3601093?pdf=render