Výsledky vyhledávání - "metabolism [Interleukin-6]"

Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation

Autor: Gerhild van Echten-Deckert, Marc P. Hübner, Indulekha Karunakaran, Stefan J. Frohberger, Markus H. Gräler, Benedikt V. Hölbling, Beatrix Schumak, Annett Halle, Shah Alam, Surendar Jayagopi, Jan N. Hansen, Janina M. Kuehlwein

Publikováno v: Glia
Glia 67(10), 1859-1872 (2019). doi:10.1002/glia.23663

Microglia mediated responses to neuronal damage in the form of neuroinflammation is a common thread propagating neuropathology. In this study, we investigated the microglial alterations occurring as a result of sphingosine 1-phosphate (S1P) accumulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9424d59cec094c5cf52b7b2609d894
https://doi.org/10.1002/glia.23663

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Genetically downregulated interleukin-6 signaling is associated with a favorable cardiometabolic profile: a phenome-wide association study

Autor: Martin Dichgans, Xue Li, Scott M. Damrauer, Girish N. Nadkarni, Shefali S. Verma, Renae Judy, Evropi Theodoratou, Rainer Malik, Marios K. Georgakis, Ha My T. Vy, Marylyn D. Ritchie, Michael G. Levin, Dipender Gill

Publikováno v: Georgakis, M K, Malik, R, Li, X, Gill, D, Levin, M G, Vy, H M T, Judy, R, Ritchie, M, Verma, S S, Nadkarni, G N, Damrauer, S M & Theodoratou, E & Dichgans, M 2021, ' Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile : A Phenome-Wide Association Study ', Circulation, vol. 143, no. 11, pp. 1177-1180 . https://doi.org/10.1161/CIRCULATIONAHA.120.052604
Circulation 143(11), 1177-1180 (2021). doi:10.1161/CIRCULATIONAHA.120.052604

BackgroundInterleukin-6 (IL6) signaling is a key inflammatory pathway widely implicated in the pathogenesis of multiple diseases including autoimmune, vascular, and metabolic disorders. While IL6-receptor (IL6R) inhibitors are already in use for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec0413b4fb6d62e0f3dc4523c4ea598
https://doi.org/10.1101/2020.10.28.20220822

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Blockade of IL-6 signaling prevents paclitaxel-induced neuropathy in C57Bl/6 mice

Autor: Wolfgang Boehmerle, Hannah Muenzfeld, Matthias Endres, Petra Huehnchen

Publikováno v: Cell Death & Disease
Cell death & disease 11(1), 45 (2020). doi:10.1038/s41419-020-2239-0
Cell Death and Disease, Vol 11, Iss 1, Pp 1-13 (2020)

The microtubule-stabilizing agent paclitaxel frequently leads to chemotherapy-induced peripheral neuropathy (CIN), which further increases the burden of disease and often necessitates treatment limitations. The pathophysiology of CIN appears to invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136b1a9acdfab5985f1fc0f0856e40ba
https://doi.org/10.1038/s41419-020-2239-0

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Traumatic brain injury causes long-term behavioral changes related to region-specific increases of cerebral blood flow

Autor: Bruno Pöttker, Franziska Stöber, Michael K. E. Schäfer, Konstantin Radyushkin, Frank Angenstein, Jürgen Goldschmidt, Regina Hummel

Publikováno v: Brain structure & function 222(9), 4005-4021 (2017). doi:10.1007/s00429-017-1452-9

Traumatic brain injury (TBI) is a leading cause of disability and death and survivors often suffer from long-lasting motor impairment, cognitive deficits, anxiety disorders and epilepsy. Few experimental studies have investigated long-term sequelae a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cfa1f3ed15c57f480d6fd3bd88e017
https://doi.org/10.1007/s00429-017-1452-9

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NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Autor: Florian Hoss, Eicke Latz, Alena Grebe

Publikováno v: Circulation research 122(12), 1722-1740 (2018). doi:10.1161/CIRCRESAHA.118.311362

Inflammation is an important driver of atherosclerosis, the underlying pathology of cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is suggested to improve cardiovascular outcomes in patients with cardiovascular dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b7ab1f22619d6fa2fbb49758ad4db1
https://pubmed.ncbi.nlm.nih.gov/29880500

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Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene

Autor: Giorgi Papashvili, Fang Kuang, Vladimir Sytnyk, Igor Jakovcevski, Barbara Schmalbach, Alexander G. Nikonenko, Iryna Leshchyns'ka, Eka Lepsveridze, Melitta Schachner, Nevena Djogo, Alexander Dityatev

Publikováno v: Journal of neurochemistry 135(4), 830-844 (2015). doi:10.1111/jnc.13284

In humans, deletions/mutations in the CHL1/CALL gene are associated with mental retardation and schizophrenia. Juvenile CHL1-deficient (CHL1(-/-) ) mice have been shown to display abnormally high numbers of parvalbumin-expressing (PV(+) ) hippocampal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf76155741b4fbff68af20625446d28
https://doi.org/10.1111/jnc.13284

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Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Autor: Yeong Hann Ling, Shalini M Krishnan, Christopher G. Sobey, Henry Diep, Grant R Drummond, Ashley Mansell, Dorota Ferens, Barbara K Kemp-Harper, Christopher T. Chan, Chrishan S. Samuel, Jaye Chin-Dusting, Eicke Latz, Tim D. Hewitson

Publikováno v: Pharmacological research 116, 77-86 (2017). doi:10.1016/j.phrs.2016.12.015

To determine whether a clinically-utilised IL-1 receptor antagonist, anakinra, reduces renal inflammation, structural damage and blood pressure (BP) in mice with established hypertension.Hypertension was induced in male mice by uninephrectomy, deoxyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074f95d9e8db09c45dccc912dc2897f2
https://pub.dzne.de/record/139077

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Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling

Autor: Marie-Christine Alessi, Jean Michel Brunel, Roland Govers, Bernadette Bonardo, Imène Kara, Regina Fluhrer, Jean-François Landrier, Christian Haass, Marjorie Poggi, Franck Peiretti

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, 2013, 1833 (3), pp.602-612. ⟨10.1016/j.bbamcr.2012.11.009⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2013, 1833 (3), pp.602-612. ⟨10.1016/j.bbamcr.2012.11.009⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2013, 1833 (3), pp.602-12
Biochimica et biophysica acta / Molecular cell research 1833(3), 602-612 (2013). doi:10.1016/j.bbamcr.2012.11.009

International audience; The pleiotropic pro-inflammatory cytokine tumour necrosis factor alpha (TNF) is synthesised as a transmembrane protein that is subject to palmitoylation. In this study, the roles of this acylation on TNF-mediated biological ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735f8c2776c78cf04cd352d92798c9cc
https://hal.inrae.fr/hal-02646290

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Effects of NF-kappaB1 (p50) targeted gene disruption on ionizing radiation-induced NF-kappaB activation and TNFalpha, IL-1alpha, IL-1beta and IL-6 mRNA expression in vivo

Autor: Zhou, D, Yu, T, Chen, G, Brown, S A, Yu, Z, Mattson, M P, Thompson, J S

Publikováno v: International journal of radiation biology, vol 77, iss 7

To investigate the role of the NF-kappaB1 (p50) gene in ionizing radiation (IR)-induced NF-kappaB activation and TNFalpha, IL-1alpha, IL-1beta and IL-6 mRNA expression in vivo.NF-kappaB activation was analysed by the gel shift/supershift assay and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::6ffe8b89fd26c8fcbb05aec3726d5900
https://escholarship.org/uc/item/1w8811sm

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