Výsledky vyhledávání - "metabolism [Glutathione Peroxidase]"

Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis

Publikováno v: Cell 172, 409–422.e21 (2018)
Cell 172(3), 409-422.e21 (2018). doi:10.1016/j.cell.2017.11.048
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Selenoproteins are rare proteins among all kingdoms of life containing the 21 st amino acid, selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of selenium for sulfur. Yet the actual advantage of selenolate- versus

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https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52658

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Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

Autor: Axel Walch, Irina Ingold, Antonella Roveri, Marcus Conrad, Katalin Buday, Michaela Aichler, Fulvio Ursini, Nils Hoffard, Wolfgang Wurst, Elena Yefremova, Adrianne Tasdemir, Sebastian Doll, José Pedro Friedmann Angeli

Publikováno v: The journal of biological chemistry 290(23), 14668-14678 (2015). doi:10.1074/jbc.M115.656363
J. Biol. Chem. 290, 14668-14678 (2015)

The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06560dec7a5747f910bb964c58412bc9
https://doi.org/10.1074/jbc.m115.656363

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Reversible effects of vitamins C and E combination on oxidative stress-induced apoptosis in melamine-treated PC12 cells

Autor: Lei An, Zhigang Li, Tao Zhang

Publikováno v: Free radical research 48(2), 239-250 (2013). doi:10.3109/10715762.2013.861598

Due to its high nitrogen content, melamine was deliberately added to raw milk for increasing the apparent protein content. Previous studies showed that melamine-induced apoptosis and oxidative damage on PC12 cells and rats' hippocampus. Several evide

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https://doi.org/10.3109/10715762.2013.861598

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The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization

Autor: Carla Boitani, Marcus Conrad, Franco Mangia, Rossella Puglisi, Irene Maccari, Simona Pipolo

Publikováno v: Journal of cellular physiology / Supplement 227(4), 1420-1427 (2012). doi:10.1002/jcp.22857

The nuclear isoform of the selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (nGPx4) is expressed in haploid male germ cells, contains several cysteines and is able to oxidize protein thiols, besides glutathione. In this study we have i

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https://doi.org/10.1002/jcp.22857

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12/15-lipoxygenase–derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

Autor: Heidi Förster, Rob Hooft van Huijsduijnen, Arne Östman, Pontus Aspenström, Åsa Sandin, Frank Böhmer, Alexander Seiler, Georg W. Bornkamm, Jeroen Frijhoff, Marcus Conrad, Olof Rådmark, Markus Dagnell

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 107(36), 15774-15779 (2010). doi:10.1073/pnas.1007909107

Protein tyrosine phosphatases (PTPs) are regulated through reversible oxidation of the active-site cysteine. Previous studies have implied soluble reactive oxygen species (ROS), like H 2 O 2 , as the mediators of PTP oxidation. The potential role(s)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640dd62da51b29e9dc3912893db8f6a1
https://doi.org/10.1073/pnas.1007909107

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Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme

Autor: Valentina Bosello, Marcus Conrad, Alexander M. Mannes, Matilde Maiorino, Alexander Seiler

Publikováno v: The FASEB journal 25(7), 2135-2144 (2011). doi:10.1096/fj.10-177147

Selenoproteins are expressed in many organisms, including bacteria, insects, fish, and mammals. Yet, it has remained obscure why some organisms rely on selenoproteins while others, like yeast and plants, express Cys-containing homologues. This study

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http://hdl.handle.net/11577/157236

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Glutathione peroxidases (GPX) at work on epididymal spermatozoa: An example of the dual effect of reactive oxygen species on mammalian male fertilizing ability

Autor: Joël R. Drevet, Marcus Conrad, Fabrice Saez, Anaïs Noblanc, Ayhan Kocer, Eléonore Chabory, Rémi Cadet, Patrick Vernet

Publikováno v: J. Androl. 32, 641-650 (2011)
Journal of Andrology
Journal of Andrology, American Society of Andrology, 2011, 32 (6), pp.641-650. ⟨10.2164/jandrol.110.012823⟩
Journal of andrology 32(6), 641-650 (2011). doi:10.2164/jandrol.110.012823

International audience; The mammalian glutathione peroxidase (GPx) gene family encodes bifunctional enzymes that can work either as classical reactive oxygen species (ROS) scavengers or as thiol peroxidases, thereby introducing disulfide bridges in t

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https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=6302

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Inactivation of glutathione peroxidase following entrapment of purified alpha or beta hemoglobin chains in human erythrocytes

Autor: Rosita Gabbianelli, Giancarlo Falcioni, Anna Maria Santroni, Francesco Grelloni

Inactivation of glutathione peroxidase correlates with the rate of hemoglobin chain oxidation. The enzyme inactivation is mainly present in those conditions where the autoxidation of the oxygenated chains is followed by transformation of the oxidized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5282c2193fa63857af4167e50fcab95b
http://hdl.handle.net/11581/243086

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Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2

Autor: Ulrike Lichti, Andrew Ryscavage, Christophe Cataisson, Stuart H. Yuspa, Dolph L. Hatfield, Marcus Conrad, Susan M. Fischer, Bradley A. Carlson, Carol Mikulec, Aniruddha Sengupta

Publikováno v: The journal of investigative dermatology 133(7), 1731-1741 (2013). doi:10.1038/jid.2013.52
J. Invest. Dermatol. 133, 1731-1741 (2013)

Selenoproteins are essential molecules for the mammalian antioxidant network. We previously demonstrated that targeted loss of all selenoproteins in mouse epidermis disrupted skin and hair development, and caused premature death. In the current study

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