Výsledky vyhledávání - "metabolism [Eukaryotic Initiation Factors]"

Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease

Autor: Barbara Bettegazzi, Lisa Michelle Restelli, Fabio Grohovaz, Serena Bellani, Alessio Colombo, Daniele Zacchetti, Takashi Saito, Laura Sebastian Monasor, Stephan Frank, Takaomi C. Saido, Sabina Tahirovic, Nikolaus Deigendesch, Sven Lammich, Franca Codazzi

Publikováno v: Cell death & disease 12(8), 769 (2021). doi:10.1038/s41419-021-04062-3
Cell Death and Disease, Vol 12, Iss 8, Pp 1-14 (2021)
Cell Death & Disease

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. Increased Aβ production plays a fundamental role in the pathogenesis of the disease and BACE1, the protease that triggers the amyloidogenic processing of APP, is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abd20f498d316c22305ccdddd4e5661
https://doi.org/10.1038/s41419-021-04062-3

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Current Coverage of the mTOR Pathway by Next-Generation Sequencing Oncology Panels

Autor: Johannes Haybaeck, Victoria Sarne, Rita Seeboeck

Publikováno v: International journal of molecular sciences 20(3), 690 (2019). doi:10.3390/ijms20030690
International Journal of Molecular Sciences, Vol 20, Iss 3, p 690 (2019)
International Journal of Molecular Sciences

The mTOR pathway is in the process of establishing itself as a key access-point of novel oncological drugs and targeted therapies. This is also reflected by the growing number of mTOR pathway genes included in commercially available next-generation s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e746dc3b751c0221141e1685a35d0547
https://pub.dzne.de/record/140596

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MAMMALIAN ATAXIN-2 MODULATES TRANSLATION CONTROL AT THE PRE-INITITATION COMPLEX VIA PI3K/MTOR AND IS INDUCED BY STARVATION

Autor: Peter Kötter, Nancy Kedersha, Isabel Lastres-Becker, David Nonis, Michael Klinkenberg, Georg Auburger, Florian Eich, Myriam Gorospe, Fabrice A.C. Klein

Publikováno v: Biochimica et biophysica acta / Molecular basis of disease 1862(9), 1558-1569 (2016). doi:10.1016/j.bbadis.2016.05.017
Digital.CSIC. Repositorio Institucional del CSIC
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Ataxin-2 is a cytoplasmic protein, product of the ATXN2 gene, whose deficiency leads to obesity, while its gain-of-function leads to neural atrophy. Ataxin-2 affects RNA homeostasis, but its effects are unclear. Here, immunofluorescence analysis sugg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614ef0c224fd3957d219dd5f59f790e3
https://europepmc.org/articles/PMC4967000/

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Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

Autor: Phillip A. Sharp, Bridget M. Dolan, Kelly A. Foster, Dieter Edbauer, Chi-Fong Wang, Tomoko Tada, Morgan Sheng, Joel R. Neilson, Matthew N. Batterton, Daniel P. Seeburg

Publikováno v: Neuron 65(3), 373-384 (2010). doi:10.1016/j.neuron.2010.01.005

SummaryMicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that miR-125b and miR-132, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96d59e2d33be7585acdadb53374e835

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