Výsledky vyhledávání - "metabolism [Enkephalins]"

l-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons

Autor: Wei-Hua Chiu, Thomas Carlsson, Eberhard Weihe, Martin Klietz, Günter U. Höglinger, Candan Depboylu, Ursula Keber, Martin K.-H. Schäfer

Publikováno v: Neuroscience 331, 120-133 (2016). doi:10.1016/j.neuroscience.2016.06.017

l-3,4-Dihydroxyphenylalanine (l-DOPA) is the therapeutic gold standard in Parkinson's disease. However, most patients develop debilitating abnormal involuntary movements termed l-DOPA-induced dyskinesia (LID) as therapy-complicating side effects. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0246f1945a8c32bf971921001502ab7a
https://doi.org/10.1016/j.neuroscience.2016.06.017

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Cellular and behavioural effects of the adenosine A2areceptor antagonist KW-6002 in a rat model of l-DOPA-induced dyskinesia

Autor: M. A. Cenci, Martin Lundblad, Elisabetta Vaudano

Publikováno v: Journal of Neurochemistry; 84(6), pp 1398-1410 (2003)

We have examined the ability of KW-6002, an adenosine A2a antagonist, to modulate the dyskinetic effects of l-DOPA in 6-hydroxydopamine-lesioned rats. In animals rendered dyskinetic by a previous course of l-DOPA treatment, KW-6002 did not elicit any

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0b2e30d63e78afe6f634b8139d50fc
https://doi.org/10.1046/j.1471-4159.2003.01632.x

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