Výsledky vyhledávání - "metabolism [Cognition Disorders]"

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis

Autor: Yuan Shi, Elena Montagna, Sophie Crux, Song Shi, Kaichuan Zhu, Chengyu Zou, Mario M. Dorostkar, Carmelo Sgobio, Jochen Herms, Stéphane Marinesco, Ulrike Müller

Publikováno v: The EMBO journal 35(20), 2213-2222 (2016). doi:10.15252/embj.201694085
The EMBO Journal

Dynamic synapses facilitate activity‐dependent remodeling of neural circuits, thereby providing the structural substrate for adaptive behaviors. However, the mechanisms governing dynamic synapses in adult brain are still largely unknown. Here, we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a2078bd453643fd02f7527a1bbfdc9
https://doi.org/10.15252/embj.201694085

Zobrazit plný text záznamu

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer’s Disease Mouse Models

Autor: Gianluigi Forloni, Federica Fusco, Alessio Colombo, Emanuele Nardo, Ottavia Bernocchi, Gloria Biella, Diego Albani, Stefan F. Lichtenthaler

Publikováno v: Journal of Alzheimer's disease 53(3), 1193-1207 (2016). doi:10.3233/JAD-151135

The neuropathological hallmarks of Alzheimer's disease (AD) are extracellular plaques built up by the accumulation of the amyloid-β protein precursor (AβPP)-derived peptide β (Aβ), and intracellular tangles of hyperphosphorylated tau protein. Sir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dfe8bfcc867a7af76d2b0ddff1984d
https://doi.org/10.3233/jad-151135

Zobrazit plný text záznamu

An amyloid-like cascade hypothesis for C9orf72 ALS/FTD

Autor: Christian Haass, Dieter Edbauer

Publikováno v: Current opinion in neurobiology 36, 99-106 (2016). doi:10.1016/j.conb.2015.10.009

Expansion of a GGGGCC repeat in C9orf72 causes amyotrophic lateral sclerosis, frontotemporal dementia, or a combination of both. Bidirectional repeat transcripts sequester RNA-binding proteins into nuclear RNA foci. The repeat is translated into dipe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70137282704c49f0f353bf85648ef9c4

Zobrazit plný text záznamu

Human cyclophilin 40 unravels neurotoxic amyloids

Autor: Chad A. Dickey, Laura J. Blair, Markus Zweckstetter, Jeremy D. Baker, Dali Zheng, Stefan Becker, Leia E. Sullivan, Parth K. Solanki, Zheying Sun, Filippo Favretto, April L. Darling, Vladimir N. Uversky, Jonathan J. Sabbagh, Eckhard Mandelkow, Mackenzie D. Martin, Lindsey B. Shelton, John Koren, Amirthaa Suntharalingam, Bryce A. Nordhues

Publikováno v: PLoS Biology
PLoS Biology, Vol 15, Iss 6, p e2001336 (2017)
PLoS biology 15(6), e2001336 (2017). doi:10.1371/journal.pbio.2001336

The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is a primary pathology in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f6b2bd08582824ce677c0cf860aa60
https://hdl.handle.net/21.11116/0000-0001-7953-A

Zobrazit plný text záznamu

A novel preventive therapy for paclitaxel-induced cognitive deficits: preclinical evidence from C57BL/6 mice

Autor: Andreas Springer, Petra Huehnchen, Matthias Endres, Dorette Freyer, Wolfgang Boehmerle

Publikováno v: Translational Psychiatry 7(8), e1185-e1185 (2017). doi:10.1038/tp.2017.149
Translational Psychiatry

Chemotherapy-induced central nervous system (CNS) neurotoxicity presents an unmet medical need. Patients often report a cognitive decline in temporal correlation to chemotherapy, particularly for hippocampus-dependent verbal and visuo-spatial abiliti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33c061604dc75cc83586daf9b6af206
https://pub.dzne.de/record/139420

Zobrazit plný text záznamu

Effects of a 6-Month Cognitive Intervention Program on Brain Metabolism in Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease

Autor: Uwe Friese, Harald Hampel, Axel Rominger, Verena C. Buschert, Stefan J. Teipel, Katharina Buerger, Peter Bartenstein, Christian la Fougère, Alexander Drzezga, Christian Zach, Stefan Förster, Hans-Georg Buchholz

Publikováno v: Journal of Alzheimer's disease 25(4), 695-706 (2011). doi:10.3233/JAD-2011-100996

The effect of cognitive intervention on brain metabolism in Alzheimer's disease (AD) is largely unexplored. Therefore, we aimed to investigate clinical cognitive parameters and 18FDG PET to test for effects of a cognitive intervention in patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4b1f145bbcc5a028d9fb86c91da6a2
https://doi.org/10.3233/jad-2011-100996

Zobrazit plný text záznamu

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers

Publikováno v: Acta neuropathologica 130(4), 559-573 (2015). doi:10.1007/s00401-015-1474-4
Acta neuropathologica, vol 130, iss 4
Acta neuropathologica
Acta Neuropathologica

Clinical and neuropathological characteristics associated with G4C2 repeat expansions in chromosome 9 open reading frame 72 (C9ORF72), the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, are highly variab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1173437018c5dd2b28186873ccc666

Zobrazit plný text záznamu

Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity

Autor: Marta Anglada-Huguet, Jordi Alberch, Laura Vidal-Sancho, Albert Giralt, Xavier Xifró, Gerardo García-Díaz Barriga

Publikováno v: Neurobiology of Disease, Vol 95, Iss, Pp 22-34 (2016)
Neurobiology of disease 95, 22-34 (2016). doi:10.1016/j.nbd.2015.09.001

Huntington's disease (HD) patients and mouse models show learning and memory impairment even before the onset of motor symptoms. Deficits in hippocampal synaptic plasticity have been involved in the HD memory impairment. Several studies show that pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071fe294fd817f4a3e207595a1f57f05
https://pubmed.ncbi.nlm.nih.gov/26369879

Zobrazit plný text záznamu

Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits

Autor: Xiao-Dong, Wang, Gerhard, Rammes, Igor, Kraev, Miriam, Wolf, Claudia, Liebl, Sebastian H, Scharf, Courtney J, Rice, Wolfgang, Wurst, Florian, Holsboer, Jan M, Deussing, Tallie Z, Baram, Michael G, Stewart, Marianne B, Müller, Mathias V, Schmidt

Publikováno v: The journal of neuroscience 31(38), 13625-13634 (2011). doi:10.1523/JNEUROSCI.2259-11.2011

Childhood traumatic events hamper the development of the hippocampus and impair declarative memory in susceptible individuals. Persistent elevations of hippocampal corticotropin-releasing factor (CRF), acting through CRF receptor 1 (CRF1), in experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b1f046e61abce6b7a81d8611683aa1a5

Zobrazit plný text záznamu

Antihypertensive therapy is associated with reduced rate of conversion to Alzheimer's disease in midregional proatrial natriuretic peptide stratified subjects with mild cognitive impairment

Autor: Philine Schneider, Stefan J. Teipel, Oskar Hansson, Olga Uspenskaya, Hans-Juergen Moeller, Harald Hampel, Andrea Ernst, Henrik Zetterberg, Dan Rujescu, Kaj Blennow, Oliver Hartmann, Katharina Buerger, Andreas Bergmann, Lennart Minthon

Publikováno v: Biological psychiatry 70(2), 145-151 (2011). doi:10.1016/j.biopsych.2011.01.036

Hypertension is a major risk factor of Alzheimer's disease (AD); however, controlled studies on the effect of antihypertensive treatment on the risk of dementia are inconclusive. Therefore, a biological marker that predicts individual response to ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757d280e040e279153d88471c0e1c1d3
https://pubmed.ncbi.nlm.nih.gov/21708304

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání