Zobrazeno 1 - 10
of 25
pro vyhledávání: '"metabolism [Central Nervous System]"'
Autor:
Niamh B. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, Alana Hoffmann, Rebecca K. Holloway, Irene Molina-Gonzalez, Katharine E. Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W. McColl, Marco Prinz, Tara L. Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J. A. Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E. Miron
Publikováno v:
Nature 613(7942), 120-129 (2023). doi:10.1038/s41586-022-05534-y
Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health1, it is unknown w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228d404a8611c8450df3d12b1580b5c6
Autor:
Radke, Josefine, Ishaque, Naveed, Hostench, Xavier Pastor, Richter, Julia, Rosenstiel, Philip, Rosenwald, Andreas, Schilhabel, Markus, Schreiber, Stefanie, Vater, Inga, Wagener, Rabea, Siebert, Reiner, Bernhart, Stephan H, Binder, Hans, Borgoni, Simone, Doose, Gero, Eils, Roland, Hoffmann, Steve, Hopp, Lydia, Kleinheinz, Kortine, Kretzmer, Helene, Kreuz, Markus, Korbel, Jan, Langenberger, David, Loeffler, Markus, Juraeva, Dilafruz, Rosolowski, Maciej, Stadler, Peter F, Sungalee, Stephanie, Pritsch, Fabienne, Paramasivam, Nagarajan, Balasubramanian, Gnana Prakash, Schlesner, Matthias, Sahay, Shashwat, Weniger, Marc, Pehl, Debora, Koll, Randi, Radbruch, Helena, Osterloh, Anja, Korfel, Agnieszka, Misch, Martin, Onken, Julia, Faust, Katharina, Vajkoczy, Peter, Moskopp, Dag, Wang, Yawen, Jödicke, Andreas, Gu, Zuguang, Trümper, Lorenz, Anagnostopoulos, Ioannis, Lenze, Dido, Küppers, Ralf, Hummel, Michael, Schmitt, Clemens A, Wiestler, Otmar D, Wolf, Stephan, Unterberg, Andreas, Schumann, Elisa, Herold-Mende, Christel, Brors, Benedikt, Consortium, ICGC MMML-Seq, Wiemann, Stefan, Heppner, Frank, Wagner, Susanne, Haake, Andrea, Sieverling, Lina, Richter, Gesine, Lawerenz, Chris, Eils, Jürgen, Kerssemakers, Jules, Jaeger-Schmidt, Christina, Scholz, Ingrid, Bergmann, Anke K, Borst, Christoph, Braulke, Friederike, Uhrig, Sebastian, Burkhardt, Birgit, Claviez, Alexander, Dreyling, Martin, Eberth, Sonja, Einsele, Hermann, Frickhofen, Norbert, Haas, Siegfried, Hansmann, Martin-Leo, Karsch, Dennis, Klepl, Nicole, Hübschmann, Daniel, Kneba, Michael, Lisfeld, Jasmin, Mantovani-Löffler, Luisa, Rohde, Marius, Ott, German, Stadler, Christina, Staib, Peter, Stilgenbauer, Stephan, Zenz, Thorsten, Toprak, Umut H, Kube, Dieter, Klapper, Wolfram, Kostezka, Ulrike, Möller, Peter, Szczepanowski, Monika, Ammerpohl, Ole, Aukema, Sietse M, López, Cristina, Binder, Vera, Borkhardt, Arndt, Hoell, Jessica I, Leich, Ellen, Lichter, Peter, Nagel, Inga, Pischimariov, Jordan, Radlwimmer, Bernhard
Publikováno v:
Nature Communications 13(1), 2558 (2022). doi:10.1038/s41467-022-30050-y
Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of PCNSL have not been fully elucidated. Here, we profile and compare the whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5df204308686d74183c913ef64b414
http://edoc.mdc-berlin.de/21617/1/21617oa.pdf
http://edoc.mdc-berlin.de/21617/1/21617oa.pdf
Autor:
Stefan Prokop, Kelly R. Miller, Zoltán Cseresnyés, Raluca A. Niesner, Natalia Drost, Frank L. Heppner, Judith Houtman, Jan-Leo Rinnenthal
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific reports 10(1), 7152 (2020). doi:10.1038/s41598-020-63989-3
Scientific Reports
Scientific reports 10(1), 7152 (2020). doi:10.1038/s41598-020-63989-3
Scientific Reports
Microglia, the innate immune cells of the central nervous system (CNS) survey their surroundings with their cytoplasmic processes, phagocytose debris and rapidly respond to injury. These functions are affected by the presence of beta-Amyloid (Aβ) de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d4aba9af77a8f1fb124ee82dff868f
http://link.springer.com/article/10.1038/s41598-020-63989-3
http://link.springer.com/article/10.1038/s41598-020-63989-3
Autor:
Stefanie-Elisabeth Heumüller, Annika C. Hornberger, Alina S. Hebestreit, André Hossinger, Ina M. Vorberg
Publikováno v:
International journal of molecular sciences 23(6), 2909 (2022). doi:10.3390/ijms23062909
Transmissible spongiform encephalopathies or prion disorders are fatal infectious diseases that cause characteristic spongiform degeneration in the central nervous system. The causative agent, the so-called prion, is an unconventional infectious agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5853603e27113507f57dc8ec2ed25981
https://pubmed.ncbi.nlm.nih.gov/35328330
https://pubmed.ncbi.nlm.nih.gov/35328330
RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury
Autor:
Sina Stern, Emily E. Handley, Sebastian Dupraz, Cord Brakebusch, Jessica M. Gonyer, Brett J. Hilton, Frank Bradke, Emily R. Burnside
Publikováno v:
Neuron 109(21), 3436-3455.e9 (2021). doi:10.1016/j.neuron.2021.08.014
Stern, S, Hilton, B J, Burnside, E R, Dupraz, S, Handley, E E, Gonyer, J M, Brakebusch, C & Bradke, F 2021, ' RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury ', Neuron, vol. 109, no. 21, pp. 3436-3455 . https://doi.org/10.1016/j.neuron.2021.08.014
Stern, S, Hilton, B J, Burnside, E R, Dupraz, S, Handley, E E, Gonyer, J M, Brakebusch, C & Bradke, F 2021, ' RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury ', Neuron, vol. 109, no. 21, pp. 3436-3455 . https://doi.org/10.1016/j.neuron.2021.08.014
An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system (CNS). Here we show how the two aspects are interwoven. Genetic loss-of-function experiments determine that the smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36676c5e46932a873a389cf9bf79a94a
https://doi.org/10.1016/j.neuron.2021.08.014
https://doi.org/10.1016/j.neuron.2021.08.014
Autor:
Telma E. Santos, Marcy Zenobi-Wong, Barbara Schaffran, Nicolas Broguiere, Frank Bradke, Liane Meyn
Publikováno v:
Cell Reports, 32 (3)
Cell reports 32(3), 107907 (2020). doi:10.1016/j.celrep.2020.107907
Cell reports 32(3), 107907 (2020). doi:10.1016/j.celrep.2020.107907
During development of the central nervous system (CNS), neurons polarize and rapidly extend their axons to assemble neuronal circuits. The growth cone leads the axon to its target and drives axon growth. Here, we explored the mechanisms underlying ax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a3eaddbb3390b73b5bbfc3ca944dd2
Autor:
Cordelia Imig, Jisoo Kim, Max Schelski, Nils Brose, Andreas Husch, Brett J. Hilton, Johannes Alexander Müller, Emily R. Burnside, Frank Bradke, Susanne Schoch, Sebastian Dupraz, Tien-chen Lin, Barbara Schaffran
Publikováno v:
Neuron
Neuron 110(1), 51-69.e7 (2022). doi:10.1016/j.neuron.2021.10.007
Neuron 110(1), 51-69.e7 (2022). doi:10.1016/j.neuron.2021.10.007
Summary Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury. Neurons lose their capacity to regenerate during development, but the intracellular processes underlying this loss are unclear. We found that cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae16f8f31562c8af3b37703206e090d
http://europepmc.org/articles/PMC8730507
http://europepmc.org/articles/PMC8730507
Publikováno v:
Cells 10(8), 2019 (2021). doi:10.3390/cells10082019 special issue: "The Contribution of Non-Neuronal Cells in Neurodegeneration: From Molecular Pathogenesis to Therapeutic Challenges"
Cells
Cells, Vol 10, Iss 2019, p 2019 (2021)
Cells
Cells, Vol 10, Iss 2019, p 2019 (2021)
Neurodegenerative diseases are a heterogeneous group of disorders whose incidence is likely to duplicate in the next 30 years along with the progressive aging of the western population. Non-cell-specific therapeutics or therapeutics designed to tackl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7998ca57d3eccf4b17959edc1c3d0828
https://doi.org/10.3390/cells10082019
https://doi.org/10.3390/cells10082019
Publikováno v:
Trends in molecular medicine 25(9), 750-759 (2019). doi:10.1016/j.molmed.2019.04.010
Astrocytes fulfil several functions that collectively contribute to maintain the optimal microenvironment for neuronal function and survival. The multiplicity and complexity of these activities clearly indicates that the correct performance of astroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53467a6a21f554598041cf1876c27bb0
https://pub.dzne.de/record/140937
https://pub.dzne.de/record/140937
Autor:
Figarella, Katherine, Uzcategui, Nestor L, Mogk, Stefan, Wild, Katleen, Fallier-Becker, Petra, Neher, Jonas J, Duszenko, Michael
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific reports 8(1), 15002 (2018). doi:10.1038/s41598-018-33395-x
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific reports 8(1), 15002 (2018). doi:10.1038/s41598-018-33395-x
The flagellated parasite Trypanosoma brucei is the causative agent of Human African Trypanosomiasis (HAT). By a mechanism not well understood yet, trypanosomes enter the central nervous system (CNS), invade the brain parenchyma, and cause a fatal enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::73e4443b0d71a68c6cf7ad3feda94856
https://pubmed.ncbi.nlm.nih.gov/30302029
https://pubmed.ncbi.nlm.nih.gov/30302029