Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone

Autor: Lucia Cottone, Lorena Ligammari, Hang-Mao Lee, Helen J. Knowles, Stephen Henderson, Sara Bianco, Christopher Davies, Sandra Strauss, Fernanda Amary, Ana Paula Leite, Roberto Tirabosco, Kristian Haendler, Joachim L. Schultze, Javier Herrero, Paul O’Donnell, Agamemnon E. Grigoriadis, Paolo Salomoni, Adrienne M. Flanagan

Publikováno v: Cell death and differentiation 29(12), 2459-2471 (2022). doi:10.1038/s41418-022-01031-x

Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3.3 as the sole genetic driver present in bone-forming osteoprogenitor ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060d9f2f6a2fa9b3ca4257b925d5abd3
https://doi.org/10.1038/s41418-022-01031-x

Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice

Autor: Tobias Lindner, Jan Stenzel, Angela Kuhla, Claire Rühlmann, Bernd J. Krause, Stefan J. Teipel, Brigitte Vollmar, Nicole Power Guerra, Luisa Müller

Publikováno v: Nutrients
Nutrients 13(3), 985-(2021). doi:10.3390/nu13030985
Volume 13
Issue 3
Nutrients, Vol 13, Iss 985, p 985 (2021)

Caloric restriction (CR) slows the aging process, extends lifespan, and exerts neuroprotective effects. It is widely accepted that CR attenuates β-amyloid (Aβ) neuropathology in models of Alzheimer’s disease (AD) by so-far unknown mechanisms. One

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099afc6a9d10e3ab4f15075cc70faab1
https://pubmed.ncbi.nlm.nih.gov/33803798

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain

Autor: Maike Hartlage-Rübsamen, Tina Heiland, Ulrike Zeitschel, Maja Puchades, Steffen Roßner, Stefan F. Lichtenthaler, Corinna Höfling, Jan G. Bjaalie, Peer-Hendrik Kuhn

Publikováno v: Glia 67(2), 393-403 (2018). doi:10.1002/glia.23550
Glia

Transgenic Tg2576 mice expressing human amyloid precursor protein (hAPP) with the Swedish mutation are among the most frequently used animal models to study the amyloid pathology related to Alzheimer's disease (AD). The transgene expression in this m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3067d36b42e2e9e697a40368005ef5c1
https://pub.dzne.de/record/140451

Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study

Autor: Matthias Brendel, Franz-Josef Gildehaus, Finn Peters, Maximilian Deussing, Simon Lindner, Jochen Herms, Tanja Blume, Carola Focke, Laurence Ozmen, Nathalie L. Albert, Barbara von Ungern-Sternberg, Karlheinz Baumann, Peter Bartenstein, Axel Rominger

Publikováno v: Journal of Neuroinflammation
Journal of neuroinflammation 15(1), 307 (2018). doi:10.1186/s12974-018-1347-6
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Blume, Tanja; Focke, Carola; Peters, Finn; Deussing, Maximilian; Albert, Nathalie L.; Lindner, Simon; Gildehaus, Franz-Josef; von Ungern-Sternberg, Barbara; Ozmen, Laurence; Baumann, Karlheinz; Bartenstein, Peter; Rominger, Axel; Herms, Jochen; Brendel, Matthias (2018). Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. Journal of neuroinflammation, 15(1), p. 307. BioMed Central 10.1186/s12974-018-1347-6

Background Causal associations between microglia activation and β-amyloid (Aβ) accumulation during the progression of Alzheimer’s disease (AD) remain a matter of controversy. Therefore, we used longitudinal dual tracer in vivo small animal positr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371fc94c8eb860b8e0e97090cb981188
https://doi.org/10.1186/s12974-018-1347-6

Cytoskeleton-associated risk modifiers involved in early and rapid progression of sporadic Creutzfeldt-Jakob disease

Autor: Mohsin Shafiq, Isidre Ferrer, Saima Zafar, Matthias Schmitz, Olivier Andreoletti, Neelam Younas, Waqas Tahir, Nadeem Sheikh, Inga Zerr

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2018, 55 (5), pp.4009-4029. ⟨10.1007/s12035-017-0589-0⟩
Molecular neurobiology 55(5), 4009-4029 (2017). doi:10.1007/s12035-017-0589-0

International audience; A high priority in the prion field is to identify pre-symptomatic events and associated profile of molecular changes. In this study, we demonstrate the pre-symptomatic dysregulation of cytoskeleton assembly and its associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decd9daddee4f10c42df04db2b84a74c
http://hdl.handle.net/2445/141810