Výsledky vyhledávání - "metabolism [CA3 Region, Hippocampal]"

Nonspecific Expression in Limited Excitatory Cell Populations in Interneuron-Targeting Cre-driver Lines Can Have Large Functional Effects

Autor: Daniel Müller-Komorowska, Thoralf Opitz, Shehabeldin Elzoheiry, Michaela Schweizer, Eleonora Ambrad Giovannetti, Heinz Beck

Publikováno v: Frontiers in Neural Circuits, Vol 14 (2020)
Frontiers in Neural Circuits
Frontiers in neural circuits 14, 16 (2020). doi:10.3389/fncir.2020.00016

Transgenic Cre-recombinase expressing mouse lines are widely used to express fluorescent proteins and opto-/chemogenetic actuators, making them a cornerstone of modern neuroscience. The investigation of interneurons in particular has benefitted from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829da04db62026fc47dd5199e0a3666a
https://www.frontiersin.org/article/10.3389/fncir.2020.00016/full

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Holistic Recollection via Pattern Completion Involves Hippocampal Subfield CA3

Autor: Grande, Xenia, Berron, David, Horner, Aidan James, Bisby, James, Duzel, Emrah, Burgess, Neil

Publikováno v: The Journal of Neuroscience
The journal of neuroscience 39(41), 8100-8111 (2019). doi:10.1523/JNEUROSCI.0722-19.2019

Episodic memories typically comprise multiple elements. A defining characteristic of episodic retrieval is holistic recollection, i.e., comprehensive recall of the elements a memorized event encompasses. A recent study implicated activity in the huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::85522c5af8cee1028ec442bdbb25b67f
https://pubmed.ncbi.nlm.nih.gov/31405925

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The Tau/A152T mutation, a risk factor for frontotemporal‐spectrum disorders, leads to NR 2B receptor‐mediated excitotoxicity

Autor: Lars Krüger, Eva-Maria Mandelkow, Zuzana Šišková, Eckhard Mandelkow, Jochen Martin Decker, Astrid Sydow, Frank J.A. Dennissen

Publikováno v: EMBO reports 17(4), 552-569 (2016). doi:10.15252/embr.201541439

We report on a novel transgenic mouse model expressing human full-length Tau with the Tau mutation A152T (hTau(AT)), a risk factor for FTD-spectrum disorders including PSP and CBD Brain neurons reveal pathological Tau conformation, hyperphosphorylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123dd8d231ae9893cf0c83b86f3b874c
https://doi.org/10.15252/embr.201541439

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TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

Autor: Hugo Balleza-Tapia, André Fisahn, Gefei Chen, Sophie Crux, Yuniesky Andrade-Talavera, Daniela Papadia, Jan Johansson, Pablo Dolz-Gaitón

Publikováno v: eLife 7, e37703 (2018). doi:10.7554/eLife.37703
eLife, Vol 7 (2018)
eLife

Amyloid-β peptide (Aβ) forms plaques in Alzheimer’s disease (AD) and is responsible for early cognitive deficits in AD patients. Advancing cognitive decline is accompanied by progressive impairment of cognition-relevant EEG patterns such as gamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce47602eb69dfb0497d2ddf57594056
https://pub.dzne.de/record/140364

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Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes

Autor: Kelly A. Allers, Kelly Doolin, Thomas Frodl, André Liesener, Sina Pleiner, Darren Roddy, Chloe Farrell, Andrew Harkin, Erik O'Hanlon, Leonardo Tozzi, Veronica O'Keane

Publikováno v: Psychoneuroendocrinology 95, 8-17 (2018). doi:10.1016/j.psyneuen.2018.05.019

Background Tryptophan depletion is a well-replicated biological finding in Major Depressive Disorder (MDD). The kynurenine pathway (KP) and its rate-limiting tryptophan degrading enzyme, indolamine 2,3 dioxygenase (IDO), have been implicated in the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609c0f4dc45f853336ce055b49f4cb51
https://pub.dzne.de/record/140233

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Spatial information is preferentially processed by the distal part of CA3: Implication for memory retrieval

Autor: Vera Flasbeck, Erika Atucha, Magdalena Sauvage, Motoharu Yoshida, Nozomu H. Nakamura

Publikováno v: Behavioural brain research 354, 31-38 (2018). doi:10.1016/j.bbr.2018.07.023
Behavioural brain research 347, 116-123 (2018). doi:10.1016/j.bbr.2018.02.046

For the past decades, CA3 was considered as a single functional entity. However, strong differences between the proximal (close to the dentate gyrus) and the distal (close to CA2) parts of CA3 in terms of connectivity patterns, gene expression and el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225d9b68ebed6dbc24313bb38cffcf76
https://pub.dzne.de/record/140254

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