Zobrazeno 1 - 9
of 9
pro vyhledávání: '"metabolism [Brain Stem]"'
Autor:
Walter Maetzler, Christian la Fougère, Daniela Berg, Inga Liepelt-Scarfone, Matthias Reimold, Andrea Pilotto, Dominik Blum
Publikováno v:
European journal of nuclear medicine and molecular imaging 45(13), 2387-2395 (2018). doi:10.1007/s00259-018-4085-1
Cognitive impairment (CI) in Parkinson’s disease (PD) is associated with a widespread reduction in cortical glucose metabolism and relative increases in the cerebellum and brainstem as measured using 18F-fluorodesoxyglucose (FDG) PET. We separately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047caf300cda810fc0fbd45acfd38bf8
https://pubmed.ncbi.nlm.nih.gov/30008111
https://pubmed.ncbi.nlm.nih.gov/30008111
Autor:
Martin Hrabé de Angelis, Tania F. Gendron, Leda Dimou, Benedikt Schoser, Meike Michaelsen, Qihui Zhou, Leonard Petrucelli, Bastian Popper, Tim M. Strom, Marianne Dieterich, Jing Tan, Juliane Winkelmann, Martin H. Schludi, Kristin Rentzsch, Wolfgang Wurst, Helmut Fuchs, Sabine M. Hölter, Stephanie May, Anne von Thaden, Franziska Schreiber, Lore Becker, Valerie Gailus-Durner, Thomas Arzberger, Lillian Garrett, Dieter Edbauer, Benjamin M. Schwenk, Thomas Klopstock
Publikováno v:
Acta neuropathologica 134(2), 241-254 (2017). doi:10.1007/s00401-017-1711-0
Acta Neuropathologica
Acta Neuropathol. 134, 241–254 (2017)
Acta Neuropathologica
Acta Neuropathol. 134, 241–254 (2017)
Translation of the expanded (ggggcc)n repeat in C9orf72 patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) causes abundant poly-GA inclusions. To elucidate their role in pathogenesis, we generated transgenic mice expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec457c586cd5b2ad17c58ea04d04338
https://pub.dzne.de/record/139375
https://pub.dzne.de/record/139375
Autor:
Blanca I. Pérez‐Revuelta, Raffaella Rusconi, Michael Helwig, Bettina Winzen‐Reichert, Ruth E. Musgrove, Donato A. Di Monte, Ayse Ulusoy
Publikováno v:
EMBO molecular medicine 5(7), 1119-1127 (2013). doi:10.1002/emmm.201302475
EMBO Molecular Medicine
EMBO Molecular Medicine
α-Synuclein accumulation and pathology in Parkinson's disease typically display a caudo-rostral pattern of progression, involving neuronal nuclei in the medulla oblongata at the earliest stages. In this study, selective expression and accumulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a76945935822ea07a8e52dcc1b01120
https://doi.org/10.1002/emmm.201302475
https://doi.org/10.1002/emmm.201302475
Autor:
Peter J. Koudstaal, M. Arfan Ikram, Albert Hofman, Monique M.B. Breteler, Renske G. Wieberdink, Jacqueline C.M. Witteman
Publikováno v:
American journal of epidemiology 176(8), 699-707 (2012). doi:10.1093/aje/kws149
American Journal of Epidemiology, 176(8), 699-707. Oxford University Press
American Journal of Epidemiology, 176(8), 699-707. Oxford University Press
Insulin resistance, which plays a key role in the development of diabetes mellitus, is a putative modifiable risk factor for stroke. The aim of this study was to investigate if markers of insulin resistance were associated with risk of stroke in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b072e40f4d4de9607af5bb404001f9d
https://pure.eur.nl/en/publications/0245df0c-b4cf-4908-84d3-13b58b084f95
https://pure.eur.nl/en/publications/0245df0c-b4cf-4908-84d3-13b58b084f95
Autor:
Ovsepian, Saak V, Ovespian, Saak V, Bodeker, MacDara, O'Leary, Valerie B, Lawrence, Gary W, Oliver Dolly, J.
Publikováno v:
Brain structure & function 220(3), 1825-1838 (2015). doi:10.1007/s00429-015-1004-0
The prominent tropism of tetanus toxin (TeTx) towards peripheral nerves with retrograde transport and transfer to central neurons render it an invaluable probe for exploring fundamental neuronal processes such as endocytosis, retrograde trafficking a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b43cca9a3498b5543e5f0dded563bb
https://pub.dzne.de/record/137904
https://pub.dzne.de/record/137904
Publikováno v:
Journal of Alzheimer's disease 33(1), 35-44 (2012). doi:10.3233/JAD-2012-121009
Epigenetic mechanisms such as histone-acetylation have been implicated with learning and memory and are believed to contribute to the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Histone-deacetylase (HDAC) inhibitors w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aa4c1971f914f2fe748941fc2c2dc1
Publikováno v:
Neurology, 80(16), e176-e177. Lippincott Williams and Wilkins
Schicks, J, Schols, L, van der Knaap, M S & Synofzik, M 2013, ' Teaching NeuroImages: MRI guides genetics Leukoencephalopathy with brainstem and spinal cord involvement (LBSL) ', Neurology, vol. 80, no. 16, pp. E176-E177 . https://doi.org/10.1212/WNL.0b013e31828cf846
Neurology, 80(16), E176-E177. Lippincott Williams and Wilkins
Neurology, 80(16), E176-E177. American Academy of Neurology
Neurology 80(16), e176-e177 (2013). doi:10.1212/WNL.0b013e31828cf846
Schicks, J, Schols, L, van der Knaap, M S & Synofzik, M 2013, ' Teaching NeuroImages: MRI guides genetics Leukoencephalopathy with brainstem and spinal cord involvement (LBSL) ', Neurology, vol. 80, no. 16, pp. E176-E177 . https://doi.org/10.1212/WNL.0b013e31828cf846
Neurology, 80(16), E176-E177. Lippincott Williams and Wilkins
Neurology, 80(16), E176-E177. American Academy of Neurology
Neurology 80(16), e176-e177 (2013). doi:10.1212/WNL.0b013e31828cf846
A 12-year-old German girl presented with progressive spastic-ataxic gait and impaired fine motor skills starting from early childhood. MRI revealed striking T2-signal abnormalities in the cerebral and cerebellar white matter, pyramidal tracts and dor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec9276d74e54229329bc0a65a2bb9b5
https://hdl.handle.net/1871.1/442c9d54-008b-42d6-89d7-faccbe1a381a
https://hdl.handle.net/1871.1/442c9d54-008b-42d6-89d7-faccbe1a381a
Autor:
Allen S. Levine, Anica Klockars, Robert Fredriksson, Pawel K. Olszewski, Eckhard Wolf, Claude Marcus, Nicole Ehrhardt, Helgi B. Schiöth, Wolfgang Hans, Martin Klingenspor, Wolfgang Wurst, Thomas Klopstock, Jan Rozman, Sabine M. Hölter, Josefin A. Jacobsson, Ulf Risérus, Lore Becker, Siv Strömberg, Ralf Elvert, Helmut Fuchs, Johan Alsiö, Manfred W. Kilimann, Martin Hrabě de Angelis, Birgit Rathkolb, Valerie Gailus-Durner
Publikováno v:
PLoS Genetics; Vol 8
PLoS Genet. 8:e1002568 (2012)
PLoS Genetics
PLoS Genetics 8(3), e1002568 (2012). doi:10.1371/journal.pgen.1002568
PLoS Genetics, Vol 8, Iss 3, p e1002568 (2012)
PLoS Genet. 8:e1002568 (2012)
PLoS Genetics
PLoS Genetics 8(3), e1002568 (2012). doi:10.1371/journal.pgen.1002568
PLoS Genetics, Vol 8, Iss 3, p e1002568 (2012)
Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2766aa7e9d57fba42c625b3fa6417caf
Publikováno v:
Acta Neuropathologica
Acta neuropathologica 133(1), 79-90 (2016). doi:10.1007/s00401-016-1633-2
Acta neuropathologica 133(1), 79-90 (2016). doi:10.1007/s00401-016-1633-2
Two nerve cells types, Betz cells in layer Vb of the primary motor neocortex and α-motoneurons of the lower brainstem and spinal cord, become involved at the beginning of the pathological cascade underlying sporadic amyotrophic lateral sclerosis (sA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f803fa6b52e8600b8dc669395518b4