Zobrazeno 1 - 10
of 14
pro vyhledávání: '"metabolism [Brain Ischemia]"'
Autor:
Jan Meyer, Niklas J. Gerkau, Karl W. Kafitz, Matthias Patting, Fabian Jolmes, Christian Henneberger, Christine R. Rose
Publikováno v:
The journal of neuroscience 42(4), 552-566 (2021). doi:10.1523/JNEUROSCI.0819-21.2021
J Neurosci
J Neurosci
Fluorescence imaging is an indispensable method for analysis of diverse cellular and molecular processes, enabling, for example, detection of ions, second messengers, or metabolites. Intensity-based approaches, however, are prone to artifacts introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f3adb9969e8f875b239e3d6231c96f
https://pub.dzne.de/record/163301
https://pub.dzne.de/record/163301
Autor:
Golo Kronenberg, Karen Gertz, Burcu Ersoy, Valérie Boujon, Stephanie Wegner, Matthias Endres, Ria Uhlemann
Publikováno v:
Molecular Neurobiology
Molecular neurobiology 57(3), 1446-1458 (2019). doi:10.1007/s12035-019-01822-3
Molecular neurobiology 57(3), 1446-1458 (2019). doi:10.1007/s12035-019-01822-3
Vascular mechanisms underlying the adverse effects that depression and stress-related mental disorders have on stroke outcome are only partially understood. Identifying the transcriptomic signature of chronic stress in endothelium harvested from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07147bb1f02f08ffafe9d3d279e8e51d
http://europepmc.org/articles/PMC7060977
http://europepmc.org/articles/PMC7060977
Autor:
Clemens Messerschmidt, Marco Foddis, Sonja Blumenau, Susanne Müller, Kajetan Bentele, Manuel Holtgrewe, Celia Kun-Rodrigues, Isabel Alonso, Maria do Carmo Macario, Ana Sofia Morgadinho, Ana Graça Velon, Gustavo Santo, Isabel Santana, Saana Mönkäre, Liina Kuuluvainen, Johanna Schleutker, Minna Pöyhönen, Liisa Myllykangas, Assunta Senatore, Daniel Berchtold, Katarzyna Winek, Andreas Meisel, Aleksandra Pavlovic, Vladimir Kostic, Valerija Dobricic, Ebba Lohmann, Hasmet Hanagasi, Gamze Guven, Basar Bilgic, Jose Bras, Rita Guerreiro, Dieter Beule, Ulrich Dirnagl, Celeste Sassi
Publikováno v:
Scientific reports 11(1), 6072 (2021). doi:10.1038/s41598-021-84919-x
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Recently, several genome-wide association studies identified PHACTR1 as key locus for five diverse vascular disorders: coronary artery disease, migraine, fibromuscular dysplasia, cervical artery dissection and hypertension. Although these represent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d760b308229fb529960863502c733cd1
https://refubium.fu-berlin.de/handle/fub188/38139
https://refubium.fu-berlin.de/handle/fub188/38139
Autor:
Lilian Staerck, Golo Kronenberg, Helmut Kettenmann, Friederike Klempin, Stephanie Wegner, Karen Gertz, Wolfgang Uckert, Nadine Richter, Matthias Endres, Ria Uhlemann, Susanne A. Wolf
Publikováno v:
Acta neuropathologica 135(4), 551-568 (2017). doi:10.1007/s00401-017-1795-6
After stroke, macrophages in the ischemic brain may be derived from either resident microglia or infiltrating monocytes. Using bone marrow (BM)-chimerism and dual-reporter transgenic fate mapping, we here set out to delimit the responses of either ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a437546f0aa140714a4c266aabf7cc
https://doi.org/10.1007/s00401-017-1795-6
https://doi.org/10.1007/s00401-017-1795-6
Publikováno v:
Glia 65(9), 1550-1561 (2017). doi:10.1002/glia.23183
Glia
Glia
Stroke is one of the leading causes of death and long-term disability. In the penumbra, that is, the area surrounding the infarct core, peri-infarct depolarizations (PIDs) are accompanied by strong intracellular calcium elevations in astrocytes and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588e1d215ae13eaf7c5463da0f71b6aa
https://doi.org/10.1002/glia.23183
https://doi.org/10.1002/glia.23183
Publikováno v:
Progress in neurobiology 143, 1-35 (2016). doi:10.1016/j.pneurobio.2016.06.001
The excessive extracellular accumulation of glutamate in the ischemic brain leads to an overactivation of glutamate receptors with consequent excitotoxic neuronal death. Neuronal demise is largely due to a sustained activation of NMDA receptors for g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3372e24b079e1ec80c6b8964a9ef726b
https://doi.org/10.1016/j.pneurobio.2016.06.001
https://doi.org/10.1016/j.pneurobio.2016.06.001
Autor:
Clemens Reiffurth, Ute Lindauer, Sebastian Major, Marco Foddis, Olaf Windmüller, Eun-Jeung Kang, Gabor C. Petzold, Jens P. Dreier
Publikováno v:
Journal of cerebral blood flow & metabolism 37(5), 1687-1705 (2016). doi:10.1177/0271678X16639059
In rats, spreading depolarization induces vasodilation/hyperemia in naïve tissue but the inverse response when artificial cerebrospinal fluid is topically applied to the brain containing (a) a nitric oxide–lowering agent and (b) elevated K+. The i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3359d72a6e977f1eb6827d9d65aa5143
https://doi.org/10.1177/0271678x16639059
https://doi.org/10.1177/0271678x16639059
Autor:
Golo Kronenberg, Stephanie Wegner, Matthew Blake Wright, Matthias Endres, Ria Uhlemann, Valérie Boujon, Karen Gertz, Ulrich Laufs
Publikováno v:
Journal of molecular medicine 97(8), 1127-1138 (2019). doi:10.1007/s00109-019-01801-0
Journal of Molecular Medicine (Berlin, Germany)
Journal of Molecular Medicine (Berlin, Germany)
Peroxisome proliferator-activated receptors (PPARs) control the expression of genes involved in glucose homeostasis, lipid metabolism, inflammation, and cell differentiation. Here, we analyzed the effects of aleglitazar, a dual PPARα and PPARγ agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f167de9aa317b1f36be7747dd6383118
https://pub.dzne.de/record/140815
https://pub.dzne.de/record/140815
Autor:
Nicolle Kränkel, Johann Bauersachs, Karin Weissenborn, Xinmin S. Li, Arash Haghikia, Udo Bavendiek, Aiden Haghikia, David Schmidt, Thomas G. Liman, Zeneng Wang, Weifei Zhu, Stanley L. Hazen, Kristina Sonnenschein, Nils Bledau, Friederike Zimmermann, Markus M. Heimesaat, Matthias Endres, Daniela Fraccarollo, Ulf Landmesser, Christian Widera
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology 38(9), 2225-2235 (2018). doi:10.1161/ATVBAHA.118.311023
Objective— Gut microbiota–dependent metabolites, in particular trimethylamine N -oxide (TMAO), have recently been reported to promote atherosclerosis and thrombosis. Here, we examined for the first time the relation of TMAO and the risk of incide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd3ed9add4b75e23c236b434248e17b
https://pubmed.ncbi.nlm.nih.gov/29976769
https://pubmed.ncbi.nlm.nih.gov/29976769
Publikováno v:
Cerebral cortex 28(12), 4264-4280 (2017). doi:10.1093/cercor/bhx280
In core regions of ischemic stroke, disruption of blood flow causes breakdown of ionic gradients and, ultimately, calcium overload and cell death. In the surrounding penumbra, cells may recover upon reperfusion, but recovery is hampered by additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef13d446c64b26f564dcd92359d943f
https://pubmed.ncbi.nlm.nih.gov/29136153
https://pubmed.ncbi.nlm.nih.gov/29136153