Zobrazeno 1 - 10
of 14
pro vyhledávání: '"metabolism [Autophagosomes]"'
Autor:
Dingxi Zhou, Mariana Borsa, Daniel J. Puleston, Susanne Zellner, Jesusa Capera, Sharon Sanderson, Martina Schifferer, Svenja S. Hester, Xin Ge, Roman Fischer, Luke Jostins, Christian Behrends, Ghada Alsaleh, Anna Katharina Simon
Publikováno v:
Nature Communications 13(1), 5174 (2022). doi:10.1038/s41467-022-32718-x
CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell proliferation relies on autophagy, but identification of the autophagosomal cargo involved is missing. Here we c
Publikováno v:
The EMBO journal, 41(7):e110057
The EMBO journal 41(7), e110057 (2022). doi:10.15252/embj.2021110057
The EMBO journal 41(7), e110057 (2022). doi:10.15252/embj.2021110057
Synaptic function crucially relies on the constant supply and removal of neuronal membranes. The morphological complexity of neurons poses a significant challenge for neuronal protein transport since the machineries for protein synthesis and degradat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa05bd6d8bb51a27119bc0d73478ae71
https://www.embopress.org/doi/full/10.15252/embj.2021110057#support-information-section
https://www.embopress.org/doi/full/10.15252/embj.2021110057#support-information-section
Autor:
Bernd Knöll, Renate Lüllmann-Rauch, Paul Saftig, Christian Haass, Yasuo Uchiyama, Wolfgang Wurst, Renate Wanner, Anja Capell, Rudi D'Hooge, Georg Werner, Stijn Stroobants, Patrick Lüningschrör, Benedikt Wefers, Daniela Sinske, Soichiro Kakuta, Michael Sendtner, Benjamin Dombert, Markus Damme
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3506-3519.e6 (2020)
Cell reports 30(10), 3506-3519.e6 (2020). doi:10.1016/j.celrep.2020.02.060
Cell reports 30(10), 3506-3519.e6 (2020). doi:10.1016/j.celrep.2020.02.060
Summary: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiol
Autor:
Thomas Arzberger, Pan Gao, Günter U. Höglinger, Matthias Höllerhage, Thomas Koeglsperger, Qilin Tang, Jochen Herms
Publikováno v:
Cell Death & Disease
Cell death & disease 12(10), 854 (2021). doi:10.1038/s41419-021-04138-0
Cell Death and Disease, Vol 12, Iss 10, Pp 1-16 (2021)
Cell death & disease 12(10), 854 (2021). doi:10.1038/s41419-021-04138-0
Cell Death and Disease, Vol 12, Iss 10, Pp 1-16 (2021)
Dopaminergic (DA) cell death in Parkinson’s disease (PD) is associated with the gradual appearance of neuronal protein aggregates termed Lewy bodies (LBs) that are comprised of vesicular membrane structures and dysmorphic organelles in conjunction
Autor:
Nils C, Gassen, Jan, Papies, Thomas, Bajaj, Jackson, Emanuel, Frederik, Dethloff, Robert Lorenz, Chua, Jakob, Trimpert, Nicolas, Heinemann, Christine, Niemeyer, Friderike, Weege, Katja, Hönzke, Tom, Aschman, Daniel E, Heinz, Katja, Weckmann, Tim, Ebert, Andreas, Zellner, Martina, Lennarz, Emanuel, Wyler, Simon, Schroeder, Anja, Richter, Daniela, Niemeyer, Karen, Hoffmann, Thomas F, Meyer, Frank L, Heppner, Victor M, Corman, Markus, Landthaler, Andreas C, Hocke, Markus, Morkel, Nikolaus, Osterrieder, Christian, Conrad, Roland, Eils, Helena, Radbruch, Patrick, Giavalisco, Christian, Drosten, Marcel A, Müller
Publikováno v:
Nat Commun
Nature Communications 12(1), 3818 (2021). doi:10.1038/s41467-021-24007-w
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications 12(1), 3818 (2021). doi:10.1038/s41467-021-24007-w
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbe213434fcb363641a7a2287aa8abb
https://hdl.handle.net/21.11116/0000-000A-F8B2-5
https://hdl.handle.net/21.11116/0000-000A-F8B2-5
Publikováno v:
Molecular cell 81(6), 1337-1354.e8 (2021). doi:10.1016/j.molcel.2021.01.009
Autophagy
Autophagy
Summary Autophagy deficiency in fed conditions leads to the formation of protein inclusions highlighting the contribution of this lysosomal delivery route to cellular proteostasis. Selective autophagy pathways exist that clear accumulated and aggrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a333338618dc4db6d5ad5c8dc84c93a8
https://pub.dzne.de/record/157731
https://pub.dzne.de/record/157731
Autor:
Eicke Latz, Victor Saavedra, Matthew Mangan, Anke Penno, Mario A. Lauterbach, Lars Kuerschner, Christoph Thiele
Publikováno v:
Autophagy
Autophagy 17(8), 1947-1961 (2021). doi:10.1080/15548627.2020.1804677
Autophagy 17(8), 1947-1961 (2021). doi:10.1080/15548627.2020.1804677
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids of clinical relevance as they are elevated in plasma of patients suffering from hereditary sensory and autonomic neuropathy (HSAN1) or type 2 diabetes. Their neurotoxicity is described best b
Autor:
Sheila Hoffmann-Conaway, Anil Annamneedi, Craig C. Garner, Eckart D. Gundelfinger, Carolina Montenegro-Venegas
Publikováno v:
Autophagy
Autophagy 16(9), 1732-1733 (2020). doi:10.1080/15548627.2020.1801259
Autophagy 16(9), 1732-1733 (2020). doi:10.1080/15548627.2020.1801259
Maintaining the integrity and function of the presynaptic neurotransmitter release apparatus is a demanding process for a post-mitotic neuron; the mechanisms behind it are still unclear. BSN (bassoon), an active zone scaffolding protein, has been imp
Autor:
Niko-Petteri Nykänen, Christian Behrends, Tasnim Chakroun, Thomas W. Rösler, Günter U. Höglinger, Matthias Höllerhage, Wolfgang Wurst, Natascha Fussi, Thomas Koeglsperger
Publikováno v:
Cell Death & Disease
Cell death & disease 9(7), 757 (2018). doi:10.1038/s41419-018-0816-2
Cell Death Dis. 9:757 (2018)
Cell Death and Disease, Vol 9, Iss 7, Pp 1-14 (2018)
Cell death & disease 9(7), 757 (2018). doi:10.1038/s41419-018-0816-2
Cell Death Dis. 9:757 (2018)
Cell Death and Disease, Vol 9, Iss 7, Pp 1-14 (2018)
Accumulation of pathological α-synuclein aggregates plays a major role in Parkinson’s disease. Macroautophagy is a mechanism to degrade intracellular protein aggregates by wrapping them into autophagosomes, followed by fusion with lysosomes. We ha
Autor:
Murdoch, John D., Rostosky, Christine M., Gowrisankaran, Sindhuja, Arora, Amandeep S., Soukup, Sandra-Fausia, Vidal, Ramon, Capece, Vincenzo, Freytag, Siona, Fischer, Andre, Verstreken, Patrik, Bonn, Stefan, Raimundo, Nuno, Milosevic, Ira
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1071-1086 (2016)
Cell reports 17(4), 1071-1086 (2016). doi:10.1016/j.celrep.2016.09.058
Cell Reports
Cell reports 17(4), 1071-1086 (2016). doi:10.1016/j.celrep.2016.09.058
Cell Reports
Summary Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4f5b2fbe8ae6600dff8e31462cab31a7
http://resolver.sub.uni-goettingen.de/purl?gs-1/13844
http://resolver.sub.uni-goettingen.de/purl?gs-1/13844