Zobrazeno 1 - 10
of 146
pro vyhledávání: '"metabolism [Aspartic Acid]"'
Autor:
Alkmini A, Papadopoulou, Walter, Stelzer, Mara, Silber, Christine, Schlosser, Charlotte, Spitz, Martina, Haug-Kröper, Tobias, Straub, Stephan A, Müller, Stefan F, Lichtenthaler, Claudia, Muhle-Goll, Dieter, Langosch, Regina, Fluhrer
Publikováno v:
Scientific Reports, 12 (1), Art.-Nr.: 20987
Scientific reports 12(1), 20987 (2022). doi:10.1038/s41598-022-24772-8
Scientific reports 12(1), 20987 (2022). doi:10.1038/s41598-022-24772-8
Signal-Peptide Peptidase Like-3 (SPPL3) is an intramembrane cleaving aspartyl protease that causes secretion of extracellular domains from type-II transmembrane proteins. Numerous Golgi-localized glycosidases and glucosyltransferases have been identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d045c596e352ffd9b2b25e9120ca7b91
https://doi.org/10.1038/s41598-022-24772-8
https://doi.org/10.1038/s41598-022-24772-8
Autor:
Linda M. Bonnekoh, Stephanie Seidenbecher, Katrin Knigge, Anne-Kathrin Hünecke, Coraline D. Metzger, Claus Tempelmann, Martin Kanowski, Jörn Kaufmann, Gabriela Meyer-Lotz, Konstantin Schlaaff, Henrik Dobrowolny, Leonardo Tozzi, Dorothee M. Gescher, Johann Steiner, Clemens Kirschbaum, Thomas Frodl
Publikováno v:
The world journal of biological psychiatry 24(1), 34-45 (2023). doi:10.1080/15622975.2022.2058084
Objectives Major Depression (MDD) and anxiety disorders are stress-related disorders that share pathophysiological mechanisms. There is evidence for alterations of glutamate-glutamine, N-acetylaspartate (NAA) and GABA in the anterior cingulate cortex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e4f234e5001d919fe37bf9b8b49f9f
Publikováno v:
Current opinion in neurobiology 72, 101-110 (2022). doi:10.1016/j.conb.2021.09.003
Secretases are a group of proteases that are major drug targets considered for the prevention and treatment of Alzheimer's disease (AD). Secretases do not only process the AD-linked neuronal amyloid precursor protein (APP) but also the triggering rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401e2110e947041283c0732a413a05a0
https://pub.dzne.de/record/163268
https://pub.dzne.de/record/163268
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease
Autor:
Barbara Bettegazzi, Lisa Michelle Restelli, Fabio Grohovaz, Serena Bellani, Alessio Colombo, Daniele Zacchetti, Takashi Saito, Laura Sebastian Monasor, Stephan Frank, Takaomi C. Saido, Sabina Tahirovic, Nikolaus Deigendesch, Sven Lammich, Franca Codazzi
Publikováno v:
Cell death & disease 12(8), 769 (2021). doi:10.1038/s41419-021-04062-3
Cell Death and Disease, Vol 12, Iss 8, Pp 1-14 (2021)
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 8, Pp 1-14 (2021)
Cell Death & Disease
Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. Increased Aβ production plays a fundamental role in the pathogenesis of the disease and BACE1, the protease that triggers the amyloidogenic processing of APP, is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abd20f498d316c22305ccdddd4e5661
https://doi.org/10.1038/s41419-021-04062-3
https://doi.org/10.1038/s41419-021-04062-3
Autor:
Tobias Lindner, Jan Stenzel, Angela Kuhla, Claire Rühlmann, Bernd J. Krause, Stefan J. Teipel, Brigitte Vollmar, Nicole Power Guerra, Luisa Müller
Publikováno v:
Nutrients
Nutrients 13(3), 985-(2021). doi:10.3390/nu13030985
Volume 13
Issue 3
Nutrients, Vol 13, Iss 985, p 985 (2021)
Nutrients 13(3), 985-(2021). doi:10.3390/nu13030985
Volume 13
Issue 3
Nutrients, Vol 13, Iss 985, p 985 (2021)
Caloric restriction (CR) slows the aging process, extends lifespan, and exerts neuroprotective effects. It is widely accepted that CR attenuates β-amyloid (Aβ) neuropathology in models of Alzheimer’s disease (AD) by so-far unknown mechanisms. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099afc6a9d10e3ab4f15075cc70faab1
https://pubmed.ncbi.nlm.nih.gov/33803798
https://pubmed.ncbi.nlm.nih.gov/33803798
Autor:
Emma Ong-Pålsson, Jasenka Rudan Njavro, Yvette Wilson, Martina Pigoni, Andree Schmidt, Stephan A. Müller, Michael Meyer, Jana Hartmann, Marc Aurel Busche, Jenny M. Gunnersen, Kathryn M. Munro, Stefan F. Lichtenthaler
Publikováno v:
Molecular neurobiology 59(2), 1183-1198 (2022). doi:10.1007/s12035-021-02660-y
The membrane protein seizure 6–like (SEZ6L) is a neuronal substrate of the Alzheimer’s disease protease BACE1, and little is known about its physiological function in the nervous system. Here, we show that SEZ6L constitutive knockout mice display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa386019a5cc6178d4c136884ad54daf
https://mediatum.ub.tum.de/1704966
https://mediatum.ub.tum.de/1704966
Autor:
Rohit Kumar, Julia Herber, Peter Jedlicka, Jakob Klotz, Jasenka Rudan Njavro, Bastian Dislich, Peer-Hendrik Kuhn, Regina Feederle, Stephan A. Müller, Marcus Conrad, Andreas Vlachos, Stylianos Michalakis, Stefan F. Lichtenthaler, Johanna Wanngren, Wolfgang Wurst, Thomas Koeglsperger, Merav D. Shmueli
Publikováno v:
Rudan Njavro, Jasenka; Klotz, Jakob; Dislich, Bastian; Wanngren, Johanna; Shmueli, Merav D; Herber, Julia; Kuhn, Peer-Hendrik; Kumar, Rohit; Koeglsperger, Thomas; Conrad, Marcus; Wurst, Wolfgang; Feederle, Regina; Vlachos, Andreas; Michalakis, Stylianos; Jedlicka, Peter; Müller, Stephan A; Lichtenthaler, Stefan F (2020). Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1. FASEB journal, 34(2), pp. 2465-2482. Federation of American Societies for Experimental Biology 10.1096/fj.201902347R
The FASEB journal 34(2), 2465-2482 (2020). doi:10.1096/fj.201902347R
The FASEB journal 34(2), 2465-2482 (2020). doi:10.1096/fj.201902347R
The protease beta-site APP cleaving enzyme 1 (BACE1) has fundamental functions in the nervous system. Its inhibition is a major therapeutic approach in Alzheimer's disease, because BACE1 cleaves the amyloid precursor protein (APP), thereby catalyzing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c80633f97dde48d1236523da32d643
Autor:
Thomas Endres, Stefan Vielhaber, Kerstin Hallmann, Niki Karavasili, Marten Szibor, Frank Schreiber, T. M. Gainutdinov, Volkmar Lessmann, Michael Schwarzer, Zemfira Gizatullina, Torsten Doenst, Matthias Kunz, Wolfram S. Kunz, Grazyna Debska-Vielhaber, Frank N. Gellerich, Alexandra Bamberger, Hans-Jochen Heinze
Publikováno v:
The journal of biological chemistry 295(14), 4383-4397 (2020). doi:10.1074/jbc.RA119.011902
The journal of biological chemistry, 295(14):4383-4397
The Journal of Biological Chemistry
The journal of biological chemistry, 295(14):4383-4397
The Journal of Biological Chemistry
Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3d6448d2f54ea5c8e34997c143a0fa
An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome
Autor:
Johanna Tüshaus, Dmitrij Frishman, Minhui Su, Gökhan Güner, Stefan F. Lichtenthaler, Mikael Simons, Georg Jocher, Sabina Tahirovic, Jan Zaucha, Laura Sebastian Monasor, Stephan A. Müller, Evans Kataka
Publikováno v:
The EMBO journal 39(20), e105693 (2020). doi:10.15252/embj.2020105693
The EMBO Journal
The EMBO Journal
To understand how cells communicate in the nervous system, it is essential to define their secretome, which is challenging for primary cells because of large cell numbers being required. Here, we miniaturized secretome analysis by developing the “h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e431959c6cfdf27737f316819ef48ffc
https://pub.dzne.de/record/154360
https://pub.dzne.de/record/154360
Autor:
Tanja Blume, Severin Filser, Etienne Herzog, Jochen Herms, Mario M. Dorostkar, Finn Peters, Derya R. Shimshek, Nils Brose, Hazal Salihoglu, Eva Ferreira Rodrigues, Ulf Neumann
Publikováno v:
Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2018, 135 (5), pp.695-710. ⟨10.1007/s00401-017-1804-9⟩
Acta Neuropathologica (Berl)
Acta neuropathologica 135(5), 695-710 (2018). doi:10.1007/s00401-017-1804-9
Acta Neuropathologica, Springer Verlag, 2018, 135 (5), pp.695-710. ⟨10.1007/s00401-017-1804-9⟩
Acta Neuropathologica (Berl)
Acta neuropathologica 135(5), 695-710 (2018). doi:10.1007/s00401-017-1804-9
BACE1 is the rate-limiting protease in the production of synaptotoxic β-amyloid (Aβ) species and hence one of the prime drug targets for potential therapy of Alzheimer’s disease (AD). However, so far pharmacological BACE1 inhibition failed to res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af044c91d1bf50ef951bb3c095454513
https://doi.org/10.1007/s00401-017-1804-9
https://doi.org/10.1007/s00401-017-1804-9