Zobrazeno 1 - 10
of 93
pro vyhledávání: '"metabolism [Amyloid beta-Protein Precursor]"'
Autor:
Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M. Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A. Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K. Peter R. Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C. Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J. Neher
Publikováno v:
Nature 612(7938), 123-131 (2022). doi:10.1038/s41586-022-05440-3
Nature 612, 123-131 (2022)
Nature 612, 123-131 (2022)
Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of age1,2, making it the most common amyloid currently known. We recently reported that medin al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c91db7a3628281af11389c3f665f1a
https://doi.org/10.1038/s41586-022-05440-3
https://doi.org/10.1038/s41586-022-05440-3
Autor:
Constanze Depp, Ting Sun, Andrew Octavian Sasmita, Lena Spieth, Stefan A. Berghoff, Taisiia Nazarenko, Katharina Overhoff, Agnes A. Steixner-Kumar, Swati Subramanian, Sahab Arinrad, Torben Ruhwedel, Wiebke Möbius, Sandra Göbbels, Gesine Saher, Hauke B. Werner, Alkmini Damkou, Silvia Zampar, Oliver Wirths, Maik Thalmann, Mikael Simons, Takashi Saito, Takaomi Saido, Dilja Krueger-Burg, Riki Kawaguchi, Michael Willem, Christian Haass, Daniel Geschwind, Hannelore Ehrenreich, Ruth Stassart, Klaus-Armin Nave
Publikováno v:
Nature
Nature 618(7964), 349-357 (2023). doi:10.1038/s41586-023-06120-6
Nature
The incidence of Alzheimer’s disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects oligodendrocytes and the structural integrity of mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435f389ad4cc0ab2ddfe2af58fae5f56
https://hdl.handle.net/21.11116/0000-000D-3A17-921.11116/0000-000D-3A19-7
https://hdl.handle.net/21.11116/0000-000D-3A17-921.11116/0000-000D-3A19-7
Autor:
Annie J. Lee, Neha S. Raghavan, Prabesh Bhattarai, Tohid Siddiqui, Sanjeev Sariya, Dolly Reyes-Dumeyer, Xena E. Flowers, Sarah A. L. Cardoso, Philip L. De Jager, David A. Bennett, Julie A. Schneider, Vilas Menon, Yanling Wang, Rafael A. Lantigua, Martin Medrano, Diones Rivera, Ivonne Z. Jiménez-Velázquez, Walter A. Kukull, Adam M. Brickman, Jennifer J. Manly, Giuseppe Tosto, Caghan Kizil, Badri N. Vardarajan, Richard Mayeux
Publikováno v:
Acta neuropathologica 144, 59-79 (2022). doi:10.1007/s00401-022-02431-6
Alzheimer’s disease (AD) has been associated with cardiovascular and cerebrovascular risk factors (CVRFs) during middle age and later and is frequently accompanied by cerebrovascular pathology at death. An interaction between CVRFs and genetic vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffdebddbbbc62cfa5b9b39c56e04f88
https://doi.org/10.1007/s00401-022-02431-6
https://doi.org/10.1007/s00401-022-02431-6
Autor:
Nadine T. Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F. Lichtenthaler, Harald Steiner, Dieter Langosch
Publikováno v:
Communications biology 6(1), 177 (2023). doi:10.1038/s42003-023-04470-5
Intramembrane proteases play a pivotal role in biology and medicine, but how these proteases decode cleavability of a substrate transmembrane (TM) domain remains unclear. Here, we study the role of conformational flexibility of a TM domain, as determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0d1b01b42d40c047d697be128ab65e
https://pub.dzne.de/record/255140
https://pub.dzne.de/record/255140
Autor:
Jasenka Rudan Njavro, Marija Vukicevic, Emma Fiorini, Lina Dinkel, Stephan A. Müller, Anna Berghofer, Chiara Bordier, Stanislav Kozlov, Annett Halle, Katrin Buschmann, Anja Capell, Camilla Giudici, Michael Willem, Regina Feederle, Stefan F. Lichtenthaler, Chiara Babolin, Paolo Montanari, Andrea Pfeifer, Marie Kosco-Vilbois, Sabina Tahirovic
Publikováno v:
Cells; Volume 12; Issue 1; Pages: 79
Cells 12(1), 79 (2022). doi:10.3390/cells12010079
Cells 12(1), 79 (2022). doi:10.3390/cells12010079
Amyloid-β (Aβ) deposition is an initiating factor in Alzheimer’s disease (AD). Microglia are the brain immune cells that surround and phagocytose Aβ plaques, but their phagocytic capacity declines in AD. This is in agreement with studies that as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b835e1d6dce3faba701e8c08fde15de
Autor:
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez
Publikováno v:
Molecular neurodegeneration 17(1), 41 (2022). doi:10.1186/s13024-022-00547-7
Molecular neurodegeneration, vol 17, iss 1
Molecular neurodegeneration, vol 17, iss 1
Background Genetic mutations underlying familial Alzheimer’s disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression of mutated transgenes have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92948ac9078e4a981efd19c2bc30f392
https://doi.org/10.1186/s13024-022-00547-7
https://doi.org/10.1186/s13024-022-00547-7
Publikováno v:
Current opinion in neurobiology 72, 101-110 (2022). doi:10.1016/j.conb.2021.09.003
Secretases are a group of proteases that are major drug targets considered for the prevention and treatment of Alzheimer's disease (AD). Secretases do not only process the AD-linked neuronal amyloid precursor protein (APP) but also the triggering rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401e2110e947041283c0732a413a05a0
https://pub.dzne.de/record/163268
https://pub.dzne.de/record/163268
Autor:
Lukas P Feilen, Shu-Yu Chen, Akio Fukumori, Regina Feederle, Martin Zacharias, Harald Steiner
Publikováno v:
eLife 11, e76090 (2022). doi:10.7554/eLife.76090
Cleavage of membrane proteins in the lipid bilayer by intramembrane proteases is crucial for health and disease. Although different lipid environments can potently modulate their activity, how this is linked to their structural dynamics is unclear. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b12ecde24eb2e5c00874886cc786ece
https://pub.dzne.de/record/164087
https://pub.dzne.de/record/164087
Autor:
Dieter Langosch, Hannes Heinel, Christina Scharnagl, Claudia Muhle-Goll, Harald Steiner, Philipp Högel, Simon Menig, Daniel Huster, Alexander Götz, Nadine Mylonas, Frits Kamp, Burkhard Luy, Alexander Vogel, Mara Silber, Hannes Feyrer
Publikováno v:
Biophys J
Biophysical journal 116(11), 2103-2120 (2019). doi:10.1016/j.bpj.2019.04.030
Biophysical journal 116(11), 2103-2120 (2019). doi:10.1016/j.bpj.2019.04.030
Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is implicated in Alzheimer’s disease pathogenesis. Biophysical data have suggested that the N-terminal part of the C99 transmembrane domain (TMD) is separated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43179bc7d9a088e925fbc9d25ec19287
https://doi.org/10.1016/j.bpj.2019.04.030
https://doi.org/10.1016/j.bpj.2019.04.030
Autor:
Paul S. Aisen, Robert Vassar, Pierre N. Tariot, Bart De Strooper, Colin L. Masters, Christian Haass, Randall J. Bateman, Stefan F. Lichtenthaler, Eric M. Reiman, Riqiang Yan, Iryna Voytyuk, Reisa A. Sperling, Maria C. Carrillo, Eric McDade
Publikováno v:
Nature reviews / Neurology 17(11), 703-714 (2021). doi:10.1038/s41582-021-00545-1
Alzheimer disease (AD) is the most common cause of dementia in older individuals (>65 years) and has a long presymptomatic phase. Preventive therapies for AD are not yet available, and potential disease-modifying therapies targeting amyloid-β plaque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4d4a5b85cd63581cae56b3cce0004b