Zobrazeno 1 - 10
of 384
pro vyhledávání: '"metabolism [Amyloid]"'
Autor:
Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M. Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A. Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K. Peter R. Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C. Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J. Neher
Publikováno v:
Nature 612(7938), 123-131 (2022). doi:10.1038/s41586-022-05440-3
Nature 612, 123-131 (2022)
Nature 612, 123-131 (2022)
Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of age1,2, making it the most common amyloid currently known. We recently reported that medin al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c91db7a3628281af11389c3f665f1a
https://doi.org/10.1038/s41586-022-05440-3
https://doi.org/10.1038/s41586-022-05440-3
Autor:
Constanze Depp, Ting Sun, Andrew Octavian Sasmita, Lena Spieth, Stefan A. Berghoff, Taisiia Nazarenko, Katharina Overhoff, Agnes A. Steixner-Kumar, Swati Subramanian, Sahab Arinrad, Torben Ruhwedel, Wiebke Möbius, Sandra Göbbels, Gesine Saher, Hauke B. Werner, Alkmini Damkou, Silvia Zampar, Oliver Wirths, Maik Thalmann, Mikael Simons, Takashi Saito, Takaomi Saido, Dilja Krueger-Burg, Riki Kawaguchi, Michael Willem, Christian Haass, Daniel Geschwind, Hannelore Ehrenreich, Ruth Stassart, Klaus-Armin Nave
Publikováno v:
Nature
Nature 618(7964), 349-357 (2023). doi:10.1038/s41586-023-06120-6
Nature
The incidence of Alzheimer’s disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects oligodendrocytes and the structural integrity of mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435f389ad4cc0ab2ddfe2af58fae5f56
https://hdl.handle.net/21.11116/0000-000D-3A17-921.11116/0000-000D-3A19-7
https://hdl.handle.net/21.11116/0000-000D-3A17-921.11116/0000-000D-3A19-7
Autor:
Annie J. Lee, Neha S. Raghavan, Prabesh Bhattarai, Tohid Siddiqui, Sanjeev Sariya, Dolly Reyes-Dumeyer, Xena E. Flowers, Sarah A. L. Cardoso, Philip L. De Jager, David A. Bennett, Julie A. Schneider, Vilas Menon, Yanling Wang, Rafael A. Lantigua, Martin Medrano, Diones Rivera, Ivonne Z. Jiménez-Velázquez, Walter A. Kukull, Adam M. Brickman, Jennifer J. Manly, Giuseppe Tosto, Caghan Kizil, Badri N. Vardarajan, Richard Mayeux
Publikováno v:
Acta neuropathologica 144, 59-79 (2022). doi:10.1007/s00401-022-02431-6
Alzheimer’s disease (AD) has been associated with cardiovascular and cerebrovascular risk factors (CVRFs) during middle age and later and is frequently accompanied by cerebrovascular pathology at death. An interaction between CVRFs and genetic vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffdebddbbbc62cfa5b9b39c56e04f88
https://doi.org/10.1007/s00401-022-02431-6
https://doi.org/10.1007/s00401-022-02431-6
Autor:
Friederike Völter, Leonie Beyer, Florian Eckenweber, Maximilian Scheifele, Ngoc Bui, Marianne Patt, Henryk Barthel, Sabrina Katzdobler, Carla Palleis, Nicolai Franzmeier, Johannes Levin, Robert Perneczky, Boris-Stephan Rauchmann, Osama Sabri, Jimin Hong, Paul Cumming, Axel Rominger, Kuangyu Shi, Peter Bartenstein, Matthias Brendel
Publikováno v:
European journal of nuclear medicine and molecular imaging 50, 1384-1394 (2023). doi:10.1007/s00259-022-06087-y
Völter, Friederike; Beyer, Leonie; Eckenweber, Florian; Scheifele, Maximilian; Bui, Ngoc; Patt, Marianne; Barthel, Henryk; Katzdobler, Sabrina; Palleis, Carla; Franzmeier, Nicolai; Levin, Johannes; Perneczky, Robert; Rauchmann, Boris-Stephan; Sabri, Osama; Hong, Jimin; Cumming, Paul; Rominger, Axel; Shi, Kuangyu; Bartenstein, Peter and Brendel, Matthias (2023). Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings. European journal of nuclear medicine and molecular imaging, 50(5), pp. 1384-1394. Springer 10.1007/s00259-022-06087-y
Völter, Friederike; Beyer, Leonie; Eckenweber, Florian; Scheifele, Maximilian; Bui, Ngoc; Patt, Marianne; Barthel, Henryk; Katzdobler, Sabrina; Palleis, Carla; Franzmeier, Nicolai; Levin, Johannes; Perneczky, Robert; Rauchmann, Boris-Stephan; Sabri, Osama; Hong, Jimin; Cumming, Paul; Rominger, Axel; Shi, Kuangyu; Bartenstein, Peter and Brendel, Matthias (2023). Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings. European journal of nuclear medicine and molecular imaging, 50(5), pp. 1384-1394. Springer 10.1007/s00259-022-06087-y
Purpose Characteristic features of amyloid-PET (A), tau-PET (T), and FDG-PET (N) can serve for the A/T/N classification of neurodegenerative diseases. Recent studies showed that the early, perfusion-weighted phases of amyloid- or tau-PET recordings s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57997d985133675880d9ad8d44f0ae70
https://doi.org/10.1007/s00259-022-06087-y
https://doi.org/10.1007/s00259-022-06087-y
Autor:
Nicholas R. Livingston, Valeria Calsolaro, Rainer Hinz, Joseph Nowell, Sanara Raza, Steve Gentleman, Robin J. Tyacke, Jim Myers, Ashwin V. Venkataraman, Robert Perneczky, Roger N. Gunn, Eugenii A. Rabiner, Christine A. Parker, Philip S. Murphy, Paul B. Wren, David J. Nutt, Paul M. Matthews, Paul Edison
Publikováno v:
Molecular psychiatry 27, 2019-2029 (2022). doi:10.1038/s41380-021-01429-y
Livingston, N R, Calsolaro, V, Hinz, R, Nowell, J, Raza, S, Gentleman, S, Tyacke, R J, Myers, J, Venkataraman, A V, Perneczky, R, Gunn, R N, Rabiner, E A, Parker, C A, Murphy, P S, Wren, P B, Nutt, D J, Matthews, P M & Edison, P 2022, ' Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01429-y
Livingston, N R, Calsolaro, V, Hinz, R, Nowell, J, Raza, S, Gentleman, S, Tyacke, R J, Myers, J, Venkataraman, A V, Perneczky, R, Gunn, R N, Rabiner, E A, Parker, C A, Murphy, P S, Wren, P B, Nutt, D J, Matthews, P M & Edison, P 2022, ' Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01429-y
Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer’s disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6468b7bbd0d6203385a9a66bf7332276
https://doi.org/10.1038/s41380-021-01429-y
https://doi.org/10.1038/s41380-021-01429-y
Autor:
Altomare, Daniele, Barkhof, Frederik, Moro, Christian, Delrieu, Julien, Payoux, Pierre, Saint-Aubert, Laure, Hitzel, Anne, Molinuevo, José Luis, Grau-Rivera, Oriol, Gispert, Juan Domingo, Drzezga, Alexander, Jessen, Frank, Caprioglio, Camilla, Zeyen, Philip, Nordberg, Agneta, Savitcheva, Irina, Jelic, Vesna, Walker, Zuzana, Edison, Paul, Demonet, Jean-François, Gismondi, Rossella, Farrar, Gill, Stephens, Andrew W, Collij, Lyduine E, Frisoni, Giovanni B, Disease, Amyloid Imaging to Prevent Alzheimer’s, Scheltens, Philip, Lopes Alves, Isadora, Bouwman, Femke, Berkhof, Johannes, van Maurik, Ingrid S, Garibotto, Valentina
Publikováno v:
JAMA neurology 80(6), 548-557 (2023). doi:10.1001/jamaneurol.2023.0997
Amyloid positron emission tomography (PET) allows the direct assessment of amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this technique is currently not widely reimbursed because of the lack of appropriately designed st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10678::e327fe70758202b6f0347d9182831aac
Autor:
Nadine T. Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F. Lichtenthaler, Harald Steiner, Dieter Langosch
Publikováno v:
Communications biology 6(1), 177 (2023). doi:10.1038/s42003-023-04470-5
Intramembrane proteases play a pivotal role in biology and medicine, but how these proteases decode cleavability of a substrate transmembrane (TM) domain remains unclear. Here, we study the role of conformational flexibility of a TM domain, as determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0d1b01b42d40c047d697be128ab65e
https://pub.dzne.de/record/255140
https://pub.dzne.de/record/255140
Autor:
Lea Helena Kunze, François Ruch, Gloria Biechele, Florian Eckenweber, Karin Wind-Mark, Lina Dinkel, Paul Feyen, Peter Bartenstein, Sibylle Ziegler, Lars Paeger, Sabina Tahirovic, Jochen Herms, Matthias Brendel
Publikováno v:
International journal of molecular sciences 24(12), 10106 (2023). doi:10.3390/ijms241210106 special issue: "Neuroinflammation in the Pathogenesis of Alzheimer's Disease and Related Dementias"
Neuroinflammation is one disease hallmark on the road to neurodegeneration in primary tauopathies. Thus, immunomodulation might be a suitable treatment strategy to delay or even prevent the occurrence of symptoms and thus relieve the burden for patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06be329f01c713eaa223140ce31a0479
https://doi.org/10.20944/preprints202304.1153.v1
https://doi.org/10.20944/preprints202304.1153.v1
Autor:
Jasenka Rudan Njavro, Marija Vukicevic, Emma Fiorini, Lina Dinkel, Stephan A. Müller, Anna Berghofer, Chiara Bordier, Stanislav Kozlov, Annett Halle, Katrin Buschmann, Anja Capell, Camilla Giudici, Michael Willem, Regina Feederle, Stefan F. Lichtenthaler, Chiara Babolin, Paolo Montanari, Andrea Pfeifer, Marie Kosco-Vilbois, Sabina Tahirovic
Publikováno v:
Cells; Volume 12; Issue 1; Pages: 79
Cells 12(1), 79 (2022). doi:10.3390/cells12010079
Cells 12(1), 79 (2022). doi:10.3390/cells12010079
Amyloid-β (Aβ) deposition is an initiating factor in Alzheimer’s disease (AD). Microglia are the brain immune cells that surround and phagocytose Aβ plaques, but their phagocytic capacity declines in AD. This is in agreement with studies that as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b835e1d6dce3faba701e8c08fde15de
Autor:
Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jessen
Publikováno v:
Brain 145(4), 1473-1485 (2022). doi:10.1093/brain/awab405
We investigated whether the impact of tau-pathology on memory performance and on hippocampal/medial temporal memory function in non-demented individuals depends on the presence of amyloid pathology, irrespective of diagnostic clinical stage. We condu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7aeb0c2fead9b7ebc4210f8c72d42bd
https://doi.org/10.1093/brain/awab405
https://doi.org/10.1093/brain/awab405