Výsledky vyhledávání - "metabolism [Actin Cytoskeleton]"

Biomolecular condensation involving the cytoskeleton

Autor: Satabdee Mohapatra, Susanne Wegmann

Publikováno v: Brain research bulletin 194, 105-117 (2023). doi:10.1016/j.brainresbull.2023.01.009

Biomolecular condensation of proteins contributes to the organization of the cytoplasm and nucleoplasm. A number of condensation processes appear to be directly involved in regulating the structure, function and dynamics of the cytoskeleton. Liquid-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693e19e69139959b760f3b5e1ce45ba7
https://pub.dzne.de/record/247519

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The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome

Autor: Georg Köhr, Dušica Briševac, Dan Du, Ralf Scholz, Mohammad Nael Elagabani, Hans-Christian Kornau

Publikováno v: Journal of neurochemistry 157(3), 666-683 (2021). doi:10.1111/jnc.15230
Journal of Neurochemistry : official journal of the International Society for Neurochemistry

Fragile X syndrome (FXS), the most common inherited cause of intellectual disability, results from silencing of the fragile X mental retardation gene 1 (FMR1). The analyses of FXS patients’ brain autopsies revealed an increased density of immature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7c2faee993ea2120f6f513675e9a3e
https://pubmed.ncbi.nlm.nih.gov/33125726

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Serotonin 5-HT4 receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin

Autor: Nicholas Cole, Katrin Böhm, Lucie Bard, Monika Bijata, Schwab Mh, Bijata K, Compan, Andre Zeug, Cherkas, Jakub Wlodarczyk, Yvonne Schill, Abdel-Galil D, Dmitri A. Rusakov, Subhadip Basu, Olga Kopach, Evgeni Ponimaskin, Alexander Dityatev, Michiyuki Matsuda

Publikováno v: Communications biology 3(1), 76 (2020). doi:10.1038/s42003-020-0791-x
Communications Biology, Vol 3, Iss 1, Pp 1-16 (2020)

Activity-dependent remodeling of excitatory connections underpins memory formation in the brain. Serotonin receptors are known to contribute to such remodeling, yet the underlying molecular machinery remains poorly understood. Here, we employ high-re

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https://pub.dzne.de/record/151632

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RhoA Controls Axon Extension Independent of Specification in the Developing Brain

Autor: Sina Stern, Frank Bradke, Sebastian Dupraz, Andreas Husch, Brett J. Hilton, C.H. Coles, Cord Brakebusch, Telma E. Santos

Publikováno v: Dupraz, S, Hilton, B J, Husch, A, Santos, T E, Coles, C H, Stern, S, Brakebusch, C & Bradke, F 2019, ' RhoA Controls Axon Extension Independent of Specification in the Developing Brain ', Current biology : CB, vol. 29, no. 22, pp. 3874-3886 . https://doi.org/10.1016/j.cub.2019.09.040
Current biology 29(22), 3874-3886.e9 (2019). doi:10.1016/j.cub.2019.09.040

Summary The specification of an axon and its subsequent outgrowth are key steps during neuronal polarization, a prerequisite to wire the brain. The Rho-guanosine triphosphatase (GTPase) RhoA is believed to be a central player in these processes. Howe

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https://curis.ku.dk/portal/da/publications/rhoa-controls-axon-extension-independent-of-specification-in-the-developing-brain(b173f272-01ae-49d4-b908-4630138303be).html

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Transient localization of the Arp2/3 complex initiates neuronal dendrite branching

Autor: Gaia Tavosanis, Tomke Stürner, Maria Nemethova, Sven Bogdan, Vic Small, Jan Mueller, Yun Zhang, Anastasia Tatarnikova, Barbara Schaffran, Hermann Cuntz

Publikováno v: Development
Development 146(7), dev171397 (2019). doi:10.1242/dev.171397

The formation of neuronal dendrite branches is fundamental for the wiring and function of the nervous system. Indeed, dendrite branching enhances the coverage of the neuron's receptive field and modulates the initial processing of incoming stimuli. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f9d9bcadbf6e0a0370fd92923c3a70
https://pubmed.ncbi.nlm.nih.gov/30910826

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Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau

Autor: Dietmar Riedel, Eckhard Mandelkow, Harindranath Kadavath, Jacek Biernat, Yunior Cabrales Fontela, Markus Zweckstetter

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications 8(1), 1981 (2017). doi:10.1038/s41467-017-02230-8

Microtubule-associated proteins regulate microtubule dynamics, bundle actin filaments, and cross-link actin filaments with microtubules. In addition, aberrant interaction of the microtubule-associated protein Tau with filamentous actin is connected t

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https://doi.org/10.1038/s41467-017-02230-8

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The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics

Autor: Pierre Chryso Djoufack, Matthias Endres, Ria Uhlemann, Golo Kronenberg, Klaus Fink, Anna Foryst-Ludwig, Andreas Heinz, Clemens Kirschbaum, Ruben Marquina Barrientos, Ulrich Kintscher, Kai Kappert, Christa Thöne-Reineke, Karen Gertz

Publikováno v: Experimental neurology 306, 34-44 (2018). doi:10.1016/j.expneurol.2018.04.004

Evidence for a critical pathophysiological role of aberrant cytoskeletal dynamics is being uncovered in a growing number of neuropsychiatric syndromes. A sedentary lifestyle as well as overt psychopathology is prevalent in patients with the metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583fd22a73f170dc1b3dc97a9f629f25
https://pubmed.ncbi.nlm.nih.gov/29684438

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Antagonistic functions of MBP and CNP establish cytosolic channels in CNS myelin

Autor: Caroline Velte, Petri Kursula, Klaus-Armin Nave, Alexander Ignatev, Mikael Simons, Arne Raasakka, Nicolas Snaidero, Wiebke Möbius, Michelle S Erwig, Hauke B. Werner, Matti Myllykoski

Publikováno v: Cell Reports, Vol 18, Iss 2, Pp 314-323 (2017)
Cell reports
Cell Reports
Cell reports 18(2), 314-323 (2017). doi:10.1016/j.celrep.2016.12.053

Summary The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable of communicating with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa90f04ceb2b7ded0ca7c2b44689146
http://urn.fi/urn:nbn:fi-fe201704055960

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LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4

Autor: Karina Häbig, Thomas Hentrich, Birgit Heim, Florian Giesert, Carolin Walter, Olaf Riess, Michael Bonin, Wolfgang Wurst, Sandra Gellhaar, Verena Djuric

Publikováno v: Biochimica et biophysica acta / Molecular basis of disease 1832(12), 2352-2367 (2013). doi:10.1016/j.bbadis.2013.09.009

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common genetic cause of Parkinson's disease (PD). However, LRRK2 function and molecular mechanisms causing the parkinsonian phenotype remain widely unknown. Most of LRRK2 k

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https://doi.org/10.1016/j.bbadis.2013.09.009

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Quantitative mapping of averaged focal adhesion dynamics in migrating cells by shape normalization

Autor: Christoph Möhl, Norbert Kirchgessner, Rudolf Merkel, Bernd Hoffmann, Claudia Schäfer

Publikováno v: Journal of cell science 125, 155-165 (2012). doi:10.1242/jcs.090746
Journal of cell science 125(1), 155-165 (2012). doi:10.1242/jcs.090746

The spatially ordered formation and disassembly of focal adhesions is a basic requirement for effective cell locomotion. Because focal adhesions couple the contractile actin–myosin network to the substrate, their distribution determines the pattern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59ef04083b0029fa426f6b202aade70
https://doi.org/10.1242/jcs.090746

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