Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

Autor: Nora Cronin, Hugo Yebenes, Edward P. Morris, Anargyros Politis, Kjetil Hansen, Carla Schmidt, Andy M. Lau, Fabienne Beuron, Chloe Martens, Zainab Ahdash, Sarah V. Faull

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature communications, 10 (1
Faull, S V, Lau, A, Martens, C P V J, Ahdash, Z M, Hansen, K, Yebenes, H, Schmidt, C, Beuron, F, Cronin, N, Morris, E P & Politis, A 2019, ' Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome ', Nature Communications, vol. 10, no. 1, 3814, pp. 1-13 . https://doi.org/10.1038/s41467-019-11772-y

13 p.-5 fig.-1 tab.
Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 from activated Cullins. Here we present structures of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e0367213858bba1d6fcebccfcdc233
http://hdl.handle.net/10261/189801

The NSL complex maintains nuclear architecture stability via lamin A/C acetylation

Autor: Karoutas, A., Szymanski, W., Rausch, T., Guhathakurta, S., Rog-Zielinska, E. A., Peyronnet, R., Seyfferth, J., Chen, H. R., de Leeuw, R., Herquel, B., Kimura, Hiroshi, Mittler, G., Kohl, P., Medalia, O., Korbel, J. O., Akhtar, A.

Publikováno v: Nature Cell Biology

While nuclear lamina abnormalities are hallmarks of human diseases, their interplay with epigenetic regulators and precise epigenetic landscape remain poorly understood. Here, we show that loss of the lysine acetyltransferase MOF or its associated NS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3548ff4d5435a5924760feb5f54ba9
https://doi.org/10.5167/uzh-176015

Submembranous septins as relatively stable components of actin-based membrane skeleton

Autor: Hagiwara, A., Tanaka, Y., Hikawa, R., Morone, N., Kusumi, A., Kimura, Hiroshi, Kinoshita, M.

Publikováno v: Cytoskeleton (Hoboken, N.J.). 68(No. 9):512-25

The cell cortex is organized by the dynamic interplay between the plasma membrane, membrane proteins, and the cytoskeleton. Despite the cortical localization of septin heteropolymers in vivo and their direct interaction with phospholipid membranes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2d5b9bb925c5c9f817ff37f394e4d6
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100733700

PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling

Autor: Irina Nikonenko, Sylvain Steen, Graham Knott, Dominique Muller, Bernadett Boda, Egbert Welker

Publikováno v: Journal of Cell Biology, vol. 183, no. 6, pp. 1115-1127
The Journal of Cell Biology
The Journal of Cell Biology, Vol. 183, No 6 (2008) pp. 1115-1127

Postsynaptic density 95 (PSD-95) is an important regulator of synaptic structure and plasticity. However, its contribution to synapse formation and organization remains unclear. Using a combined electron microscopic, genetic, and pharmacological appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c60099c1c85e6f76fba855829d1724
https://doi.org/10.1083/jcb.200805132

An electron microscopic and biochemical study of the effects of glucagon on glycogen autophagy in the liver and heart of newborn rats

Autor: O. B. Kotoulas, Stefanos A. Kalamidas, D.J. Kondomerkos

Publikováno v: Microscopy Research and Technique. 63:87-93

The effects of glucagon on the ultrastructural appearance and acid glucosidase activities in the liver and heart of newborn rats were studied. Liver or heart glycogen-hydrolyzing activity of acid glucosidase increased 3 hours after birth and graduall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5e4f19fab8f6f448be282e56827532
https://doi.org/10.1002/jemt.20000