Oxidative Stress and Alterations in the Antioxidative Defense System in Neuronal Cells Derived from NPC1 Patient-Specific Induced Pluripotent Stem Cells

Autor: Moritz J. Frech, Katharina Huth, Jan Lukas, Maik Liedtke, Alexandra V Jürs, Andreas Hermann, Christin Völkner

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 20
International journal of molecular sciences 21(20), 7667-(2020). doi:10.3390/ijms21207667
International Journal of Molecular Sciences, Vol 21, Iss 7667, p 7667 (2020)

Oxidative stress (OS) represents a state of an imbalanced amount of reactive oxygen species (ROS) and/or a hampered efficacy of the antioxidative defense system. Cells of the central nervous system are particularly sensitive to OS, as they have a mas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7332a837a6bb9fca587159c46d34a479

Reversible effects of vitamins C and E combination on oxidative stress-induced apoptosis in melamine-treated PC12 cells

Autor: Lei An, Zhigang Li, Tao Zhang

Publikováno v: Free radical research 48(2), 239-250 (2013). doi:10.3109/10715762.2013.861598

Due to its high nitrogen content, melamine was deliberately added to raw milk for increasing the apparent protein content. Previous studies showed that melamine-induced apoptosis and oxidative damage on PC12 cells and rats' hippocampus. Several evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e530e556c505f741b02f0b60ab6ca2
https://doi.org/10.3109/10715762.2013.861598

Dietary zeolite supplementation reduces oxidative damage and plaque generation in the brain of an Alzheimer's disease mouse model

Autor: Giuseppina Maccarinelli, Daniela Uberti, Maurizio Memo, Mery Montinaro, Giulia Ferrari-Toninelli, Sara Anna Bonini

Publikováno v: Life Sciences. 92:903-910

Aim Oxidative stress is considered one of the main events that lead to aging and neurodegeneration. Antioxidant treatments used to counteract oxidative damage have been associated with a wide variety of side effects or at the utmost to be ineffective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ae67e2e401f842761c99276a8d35f4
https://doi.org/10.1016/j.lfs.2013.03.008

Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis

Autor: Vercruysse, Pauline, Sinniger, Jérôme, Dreyhaupt, Jens, Grehl, Torsten, Hermann, Andreas, Grosskreutz, Julian, Witting, Anke, Van Den Bosch, Ludo, Spreux-Varoquaux, Odile, Group, GERP ALS Study, Ludolph, Albert C, Dupuis, Luc, El Oussini, Hajer, Borisow, Nadja, Holm, Theresa, Maier, Andre, Meyer, Thomas, Budde, Paula, Gruhn, Kai, Bewersdorff, Malte, Heneka, Michael, Storch, Alexander, Scekic-Zahirovic, Jelena, Frank, Tobias, Göricke, Bettina, Weishaupt, Jochen, Eger, Katharina, Hanisch, Frank, Zierz, Stephan, Boeck, Anna-Lena, Dengler, Reinhard, Koerner, Sonja, Kollewe, Katja, Dieterlé, Stéphane, Petri, Susanne, Prell, Tino, Ringer, Thomas, Zinke, Jan, Anneser, Johanna, Borasio, Gian Domenico, Chahli, Christine, Winkler, Andrea S, Boentert, Matthias, Stubbe-Draeger, Bianca, Young, Peter, Bogdahn, Ulrich, Franz, Steffen, Haringer, Verena, Weidner, Norbert, Benecke, Reiner, Meister, Stefanie, Prudlo, Johannes, Wittstock, Matthias, Dorst, Johannes, Hendrich, Corinna, Sperfeld, Anne-Dorte, Weiland, Ulrike, Neidhardt, Sabine, Schrank, Berthold, Beck, Marcus, Kraft, Peter, Toyka, Klaus, Ulzheimer, Jochen, Wessig, Carsten, Kassubek, Jan, Fischer, Wilhelm

Publikováno v: Brain 139(4), 1106-1122 (2016). doi:10.1093/brain/aww004
Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2016, 139 (4), pp.1106-1122. ⟨10.1093/brain/aww004⟩
Brain-A Journal of Neurology, 2016, 139 (4), pp.1106-1122. ⟨10.1093/brain/aww004⟩

International audience; Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor impairment, patients with amyotrophic lateral sclerosis suffer from majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2100cab1af8c6c87b161388fec439336
https://pubmed.ncbi.nlm.nih.gov/26984187

The multifaceted role of glial cells in amyotrophic lateral sclerosis

Autor: Chiara F. Valori, Liliana Brambilla, Daniela Rossi, Francesca Martorana

Publikováno v: Cellular and molecular life sciences 71(2), 287-297 (2013). doi:10.1007/s00018-013-1429-7
Cellular and molecular life sciences : CMLS

Despite indisputable progress in the molecular and genetic aspects of amyotrophic lateral sclerosis (ALS), a mechanistic comprehension of the neurodegenerative processes typical of this disorder is still missing and no effective cures to halt the pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13a88ebc9c5ac9ed4a067084f216393
https://pubmed.ncbi.nlm.nih.gov/23912896