Zobrazeno 1 - 10 of 47 pro vyhledávání: '"metabolism, Spermatozoa"'
1
Transmission of trained immunity and heterologous resistance to infections across generations
Autor: Gilles Gasparoni, Andreas Schlitzer, Branko Cirovic, Joachim L. Schultze, Didier Le Roy, Kristian Händler, Evangelos J. Giamarellos-Bourboulis, Jorge Domínguez-Andrés, Jörn Walter, Leo A. B. Joosten, Marc Beyer, Jos W. M. van der Meer, Kathrin Kattler, Heidi Theis, Natalie Katzmarski, Mihai G. Netea, Eleonora Ciarlo, Georgios Renieris, Konstantin Lepikhov, Thierry Roger
Publikováno v: Nature Immunology, 22, 1382-1390
Nature immunology 22(11), 1382-1390 (2021). doi:10.1038/s41590-021-01052-7
Nature Immunology, 22, 11, pp. 1382-1390
Nat Immunol.
Intergenerational inheritance of immune traits linked to epigenetic modifications has been demonstrated in plants and invertebrates. Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d857da367f6cd3466dd53a2b7744fa3
https://hdl.handle.net/2066/241159
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2
Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility
Autor: Axel Walch, Irina Ingold, Antonella Roveri, Marcus Conrad, Katalin Buday, Michaela Aichler, Fulvio Ursini, Nils Hoffard, Wolfgang Wurst, Elena Yefremova, Adrianne Tasdemir, Sebastian Doll, José Pedro Friedmann Angeli
Publikováno v: The journal of biological chemistry 290(23), 14668-14678 (2015). doi:10.1074/jbc.M115.656363
J. Biol. Chem. 290, 14668-14678 (2015)
The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06560dec7a5747f910bb964c58412bc9
https://doi.org/10.1074/jbc.m115.656363
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3
Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice
Autor: Eckhard Wolf, Ramon O. Vidal, Anna Matynia, Frauke Neff, Birgit Rathkolb, Valerie Gailus-Durner, Anna-Lena Schütz, Helmut Fuchs, Gerhard Ehninger, Dan Ehninger, Devon Ryan, Dirk H. Busch, Jan Rozman, Cornelia Prehn, Martin Hrabě de Angelis, Stefan Bonn, Melvin Schleif, Isabelle Lehmann, Walker S. Jackson, Michel E. Mickael, Jerzy Adamski, Magali Hennion, Thure Adler, Kristin S. Henzel, Brandon L. Pearson, Susanne Schröder, Kan Xie, Marco Weiergräber
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 115(10), E2348-E2357 (2018). doi:10.1073/pnas.1707337115
Proc. Natl. Acad. Sci. U.S.A. 115, E2348-E2357 (2018)
Significance Aging-associated diseases are increasingly common in an aging global population. However, the contributors and origins of differential risk for unhealthy aging remain poorly understood. Using a mouse model, we found that offspring of age
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbd4bb7ab35140f3d778069ba8158ae
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192395
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4
RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment
Autor: Dieter Edbauer, Rezaul Islam, Eva Benito, Tonatiuh Pena-Centeno, Roman M. Stilling, Camin Dean, Qihui Zhou, Binu Ramachandran, Vincenzo Capece, Andre Fischer, Gaurav Jain, Cemil Kerimoglu
Publikováno v: Cell Reports
Cell reports 23(2), 546-554 (2018). doi:10.1016/j.celrep.2018.03.059
Cell Reports, Vol 23, Iss 2, Pp 546-554 (2018)
Summary Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer’s disease. Here, we show that exposure of adult male
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d7a15f096d355833a0cb1b30fde73c
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5
Mitochondrial replacement approaches: challenges for clinical implementation
Autor: Barbara Klopstock, Holger Prokisch, Thomas Klopstock
Publikováno v: Genome medicine 8(1), 126 (2016). doi:10.1186/s13073-016-0380-2
Genome Medicine
Genome Med. 8:126 (2016)
Genome Medicine, Vol 8, Iss 1, Pp 1-3 (2016)
Editorial summary The advent of mitochondrial replacement techniques poses many scientific, regulatory, and ethical questions. Previous studies suggest good safety and efficacy profiles of these techniques, but challenges remain for clinical implemen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a05c627278cd822a0266fadc21a6c2
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6
CRIS - a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending
Autor: Luis Alvarez, Eberhard Krause, Ari Waisman, Anke Miriam Krähling, Elisabeth Kremmer, Ingo Voigt, Ashraf Al-Amoudi, Timo Strünker, Monika Gunkel, Simone Wörtge, Dagmar Wachten, Katharina Debowski, Reinhard Seifert, Qui Van, Ulrich Benjamin Kaupp, Ingo Weyand, Stephan Irsen
Publikováno v: PLoS Genetics
PLoS Genetics 9(12), e1003960-(2013). doi:10.1371/journal.pgen.1003960
PLoS Genet. 9:e1003960 (2013)
PLoS Genetics, Vol 9, Iss 12, p e1003960 (2013)
PLoS Genetics, 9(12):e1003960
PLoS Genetics 9(12), e1003960 (2013). doi:10.1371/journal.pgen.1003960
PLoS Genet
The second messengers cAMP and cGMP activate their target proteins by binding to a conserved cyclic nucleotide-binding domain (CNBD). Here, we identify and characterize an entirely novel CNBD-containing protein called CRIS (cyclic nucleotide receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd854089f91fe7fc90ec0efafbaf5a04
https://hdl.handle.net/11858/00-001M-0000-0028-60C3-711858/00-001M-0000-0028-60C1-B
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7
Epididymis Response Partly Compensates for Spermatozoa Oxidative Defects in snGPx4 and GPx5 Double Mutant Mice
Autor: Noblanc, Anaïs, Peltier, Manon, Damon-Soubeyrand, Christelle, Kerchkove, Nicolas, Chabory, Eléonore, Vernet, Patrick, Saez, Fabrice, Cadet, Rémi, Janny, Laurent, Pons-Rejraji, Hanae, Conrad, Marcus, Drevet, Joël, Kocer, Ayhan, Bishop, Alexander James Roy
Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e38565. ⟨10.1371/journal.pone.0038565⟩
PLoS ONE, 2012, 7 (6), pp.e38565. ⟨10.1371/journal.pone.0038565⟩
PLoS ONE 7:e38565 (2012)
PLOS ONE 7(6), e38565 (2012). doi:10.1371/journal.pone.0038565
PLoS ONE, Vol 7, Iss 6, p e38565 (2012)
We report here that spermatozoa of mice lacking both the sperm nucleus glutathione peroxidase 4 (snGPx4) and the epididymal glutathione peroxidase 5 (GPx5) activities display sperm nucleus structural abnormalities including delayed and defective nucl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2680fb2aef4c23e568eb5b6f0e9ad344
https://hal.archives-ouvertes.fr/hal-02083321
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8
Novel insights into DNA methylation features in spermatozoa: stability and peculiarities
Autor: Juan Sandoval, Chiara Chianese, Claudia Giachini, Holger Heyn, Manel Esteller, Sergi Sayols, Csilla Krausz
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, Vol 7, Iss 10, p e44479 (2012)
Plos One
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
PLoS One
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Universitat Politècnica de Catalunya (UPC)
PLoS ONE
Recercat. Dipósit de la Recerca de Catalunya
Data about the entire sperm DNA methylome are limited to two sperm donors whereas studies dealing with a greater number of subjects focused only on a few genes or were based on low resolution arrays. This implies that information about what we can co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57fe6e36e6958f095e6472f78b89d79
http://hdl.handle.net/2445/175487
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10
Binding of germ cells to mutant Sld Sertoli cells is defective and is rescued by expression of the transmembrane form of the c-kit ligand
Autor: Giovanna Marziali, Domenico Lazzaro, Vincenzo Sorrentino
Publikováno v: Developmental biology. 157(1)
Mutations in the steel (Sl) locus, encoding the c-kit ligand (KL), are associated with impaired germ cell development in mice. Two forms of KL exist: one more steadily associated with the plasma membrane and one more easily released as a soluble prot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44470c2c03fc4eb323ec0d7d39215288
https://pubmed.ncbi.nlm.nih.gov/7683283
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