Zobrazeno 1 - 9
of 9
pro vyhledávání: '"metabolism, Neuroblastoma"'
Autor:
Patrick Yu-Wai-Man, Christoph Ufer, Lynn Bedford, David J. Boocock, Theodosis S. Theodosi, Aslihan Ugun-Klusek, Julia C. Fitzgerald, E. Ellen Billett, Florence Burté
Publikováno v:
Redox Biology, Vol 20, Iss, Pp 167-181 (2019)
Redox Biology 20, 167-181 (2019). doi:10.1016/j.redox.2018.10.003
Redox Biology
Redox Biology 20, 167-181 (2019). doi:10.1016/j.redox.2018.10.003
Redox Biology
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and contribute to reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee6c7f7a07ce2d77e3885777776be6e
http://www.sciencedirect.com/science/article/pii/S2213231718307341
http://www.sciencedirect.com/science/article/pii/S2213231718307341
Autor:
Zhanyun Fan, Tarun V. Kamath, Anthony A. Hyman, Charles R. Vanderburg, J. Paul Taylor, Bahareh Eftekharzadeh, Amandine Molliex, Bradley T. Hyman, Katarzyna Marta Zoltowska, Katharina Tepper, Rachel E. Bennett, Allyson D. Roe, Pawel R. Laskowski, Susanne Wegmann, Amayra Hernández-Vega, Daniel J. Müller, Caitlin Commins, Eckhard Mandelkow, Simon Dujardin, Danny MacKenzie
Publikováno v:
EMBO Journal
The EMBO Journal
The EMBO journal 37(7), e98049 (2018). doi:10.15252/embj.201798049
The EMBO Journal
The EMBO journal 37(7), e98049 (2018). doi:10.15252/embj.201798049
The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid–liquid phase separation (LLPS) under c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9167a871aa08aef02aee28352f25acf4
https://hdl.handle.net/21.11116/0000-0003-53A6-421.11116/0000-0003-53A8-2
https://hdl.handle.net/21.11116/0000-0003-53A6-421.11116/0000-0003-53A8-2
Autor:
Karina Häbig, Thomas Hentrich, Birgit Heim, Florian Giesert, Carolin Walter, Olaf Riess, Michael Bonin, Wolfgang Wurst, Sandra Gellhaar, Verena Djuric
Publikováno v:
Biochimica et biophysica acta / Molecular basis of disease 1832(12), 2352-2367 (2013). doi:10.1016/j.bbadis.2013.09.009
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common genetic cause of Parkinson's disease (PD). However, LRRK2 function and molecular mechanisms causing the parkinsonian phenotype remain widely unknown. Most of LRRK2 k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ba353f29c2943ab3f209bd31a5e546
https://doi.org/10.1016/j.bbadis.2013.09.009
https://doi.org/10.1016/j.bbadis.2013.09.009
Autor:
Henry Houlden, Victoria S Burchell, Andrea Calvo, Jessica Mandrioli, Cristina Moglia, Antonio Canosa, Colin J. Mahoney, Adriano Chiò, Selina Wray, Andrey Y. Abramov, Helene Plun-Favreau, Hsiu-Chuan Wu, Richard W. Orrell, Nick C. Fox, John Hardy, Fernando Bartolome, Elisavet Preza
Publikováno v:
Neuron
Neuron; Vol 78
Neuron; Vol 78
Summary Valosin-containing protein (VCP) is a highly expressed member of the type II AAA+ ATPase family. VCP mutations are the cause of inclusion body myopathy, Paget’s disease of the bone, and frontotemporal dementia (IBMPFD) and they account for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846563b02156730769f60c95db7a858b
https://doi.org/10.1016/j.neuron.2013.02.028
https://doi.org/10.1016/j.neuron.2013.02.028
Autor:
Bénédicte Oulès, Patrizia Paterlini-Bréchot, Dolores Del Prete, Mounia Chami, Inger Lauritzen, Barbara Greco, Xuexin Zhang, Frédéric Checler, Sébastien Moreno, Mohamed Trebak, Jean Sevalle, Fabio Benfenati
Publikováno v:
The Journal of Neuroscience. 32:11820-11834
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein (APP), thereby generating amy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0c0f6ea578d7ddc16857385cd179e1
https://doi.org/10.1523/jneurosci.0875-12.2012
https://doi.org/10.1523/jneurosci.0875-12.2012
Autor:
Mauro Piacentini, Michela Biancolella, Sandra Moreno, D. Minella, Marco Corazzari, Sara Sepe, Federica Di Sano, Roberta Nardacci, Fabio Blandini, Barbara Fazi, Giuseppe Novelli, Bisan Mehdawy, Robert Nisticò
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 3, Pp 634-644 (2010)
The endoplasmic reticulum (ER) stress-mediated pathway is involved in a wide range of human neurodegenerative disorders. Hence, molecules that regulate the ER stress response represent potential candidates as drug targets to tackle these diseases. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cf82906689623ccbc9083049c11425
https://doi.org/10.1016/j.nbd.2010.08.007
https://doi.org/10.1016/j.nbd.2010.08.007
Autor:
Naoto Sugeno, Sandra Jäckel, Aaron Voigt, Zinah Wassouf, Julia Schulze-Hentrich, Philipp J. Kahle
Publikováno v:
Scientific reports 6, 36328 (2016). doi:10.1038/srep36328
Scientific Reports
Scientific reports 6(1), 36328 (2016). doi:10.1038/srep36328
Scientific Reports
Scientific reports 6(1), 36328 (2016). doi:10.1038/srep36328
Scientific reports 6(1), 36328 (2016). doi:10.1038/srep36328
Published by Nature Publishing Group, London
Published by Nature Publishing Group, London
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99130c19bb7fa25d8e419b8d57c9a217
Autor:
Jens Hansen, Peer-Hendrik Kuhn, Wolfgang Wurst, Regina Augustin, Dietrich Trümbach, Sven Reinhardt, Stefan F. Lichtenthaler, Kristina Endres
Publikováno v:
BMC Medical Genetics
BMC Med. Genet. 13:35 (2012)
BMC Medical Genetics, Vol 13, Iss 1, p 35 (2012)
BMC medical genetics 13(1), 35 (2012). doi:10.1186/1471-2350-13-35
BMC Med. Genet. 13:35 (2012)
BMC Medical Genetics, Vol 13, Iss 1, p 35 (2012)
BMC medical genetics 13(1), 35 (2012). doi:10.1186/1471-2350-13-35
Background MicroRNAs (miRNAs) are post-transcriptional regulators involved in numerous biological processes including the pathogenesis of Alzheimer’s disease (AD). A key gene of AD, ADAM10, controls the proteolytic processing of APP and the formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e96c0c18b78e3f6fe1ef92d14550cf
https://doi.org/10.1186/1471-2350-13-35
https://doi.org/10.1186/1471-2350-13-35
Autor:
Claudio Tiribelli, Gianluca Tell, Raffaella Calligaris, Rossana Foti, Franco Quadrifoglio, Andrea Scaloni, Cristina Bellarosa, Giovanni Renzone, Sandra Vilotti, Laura Cesaratto, Marta Deganuto, Stefano Gustincich
Publikováno v:
Scopus-Elsevier
Proteomics (Weinh., Print) 10 (2010): 1645–1657. doi:10.1002/pmic.200900579
info:cnr-pdr/source/autori:Deganuto M, Cesaratto L, Bellarosa C, Calligaris R, Vilotti S, Renzone G, Foti R, Scaloni A, Gustincich S, Quadrifoglio F, Tiribelli C, Tell G./titolo:A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein./doi:10.1002%2Fpmic.200900579/rivista:Proteomics (Weinh., Print)/anno:2010/pagina_da:1645/pagina_a:1657/intervallo_pagine:1645–1657/volume:10
Proteomics (Weinh., Print) 10 (2010): 1645–1657. doi:10.1002/pmic.200900579
info:cnr-pdr/source/autori:Deganuto M, Cesaratto L, Bellarosa C, Calligaris R, Vilotti S, Renzone G, Foti R, Scaloni A, Gustincich S, Quadrifoglio F, Tiribelli C, Tell G./titolo:A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein./doi:10.1002%2Fpmic.200900579/rivista:Proteomics (Weinh., Print)/anno:2010/pagina_da:1645/pagina_a:1657/intervallo_pagine:1645–1657/volume:10
Unconjugated bilirubin (UCB) is a powerful antioxidant and a modulator of cell growth through the interaction with several signal transduction pathways. Although newborns develop a physiological jaundice, in case of severe hyperbilirubinemia UCB may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a04a0afb577d98f5e52069c23e6e1c
https://pubmed.ncbi.nlm.nih.gov/20186750
https://pubmed.ncbi.nlm.nih.gov/20186750