Zobrazeno 1 - 10
of 14
pro vyhledávání: '"metabolism, Epilepsy"'
Autor:
Nicola Masala, Martin Pofahl, André N Haubrich, Khondker Ushna Sameen Islam, Negar Nikbakht, Maryam Pasdarnavab, Kirsten Bohmbach, Kunihiko Araki, Fateme Kamali, Christian Henneberger, Kurtulus Golcuk, Laura A Ewell, Sandra Blaess, Tony Kelly, Heinz Beck
Publikováno v:
Brain 146(6), 2399-2417 (2023). doi:10.1093/brain/awac455
Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. Here, we describe a Na+ channel-dependent mechanism underlying altered hippocampal dendritic integration, degraded place codin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbeaa2b524ee2be384bba35a7ff7c581
https://pub.dzne.de/record/258241
https://pub.dzne.de/record/258241
Autor:
James D. Mills, Eleonora Aronica, Wim Van Hecke, Till S. Zimmer, Stefanie Dedeurwaerdere, Johannes C. Baayen, Sander Idema, Nicole N. van der Wel, Anatoly Korotkov, Jonathan van Eyll, Peter C. van Rijen, Rainer Surges, Erwin A. van Vliet, Helmut W. Kessels, Jan A. Gorter, Diede W. M. Broekaart, Angelika Mühlebner, Martin Schidlowski, Theodor Rüber, Bastian David, Gabriele Ruffolo, Liesbeth François
Publikováno v:
Acta Neuropathologica, 142(4), 729-759. Springer Verlag
Acta neuropathologica 142(4), 729-759 (2021). doi:10.1007/s00401-021-02348-6
Acta neuropathologica, 142(4), 729-759. Springer Verlag
Acta Neuropathologica
Acta neuropathologica 142(4), 729-759 (2021). doi:10.1007/s00401-021-02348-6
Acta neuropathologica, 142(4), 729-759. Springer Verlag
Acta Neuropathologica
Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, to date, alterations in iron metabolism in the epilep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b82eaadc30bc3f4a002607a77dba8b4
https://doi.org/10.1007/s00401-021-02348-6
https://doi.org/10.1007/s00401-021-02348-6
Autor:
Henrik Hülle, Benedikt Zott, Saskia Spahn, Markus Moser, Manuela Brümmer, Dirk Isbrandt, Christian Gruner, Stefanie Fenske, René D. Rötzer, Andreas Ludwig, Jennifer Kass, Verena Hammelmann, Anita Lüthi, Marc Sebastian Stieglitz, Jana Hartmann, Arthur Konnerth, Karim Le Meur, Christian Wahl-Schott, Martin Biel
Publikováno v:
JCI insight 4(9), e126418 (2019). doi:10.1172/jci.insight.126418
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are dually gated channels that are operated by voltage and by neurotransmitters via the cAMP system. cAMP-dependent HCN regulation has been proposed to play a key role in regulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2998d354a030cdef12f4f97f126234de
https://pub.dzne.de/record/164242
https://pub.dzne.de/record/164242
Autor:
Knut Kirmse, Harald Prüss
Publikováno v:
Brain research 1701, 146-152 (2018). doi:10.1016/j.brainres.2018.09.009
Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5b62c63e3ca303303b00276bcfcac0
Autor:
Jan A. Gorter, Sanjay M. Sisodiya, Annamaria Vezzani, Katarzyna Lukasiuk, Eleonora Aronica, Alon Friedman, Jens P. Bankstahl, Heinz Beck, Teresa Ravizza, Wolfgang Löscher, Olli Gröhn, Albert J. Becker, Asla Pitkänen, Michele Simonato, Merab Kokaia
Publikováno v:
The lancet / Neurology 15(8), 843-856 (2016). doi:10.1016/S1474-4422(16)00112-5
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs. Moreover, no treatments exist to prevent the development of epilepsy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ba75a84f46d0b4d42c40eed64d8ea1
https://pub.dzne.de/record/138612
https://pub.dzne.de/record/138612
Autor:
Susanne Schoch, Albert J. Becker, Rebecca Kulbida, Karen M.J. van Loo, Eva-Maria Mandelkow, Yipeng Wang
Publikováno v:
Brain structure & function 220(5), 3067-3073 (2014). doi:10.1007/s00429-014-0801-1
Brain Structure & Function
Brain Structure & Function
Focal epilepsies often originate in the hippocampal formation of the temporal lobe (temporal lobe epilepsy) and are generally acquired after transient brain insults. Such insults induce cellular and structural reorganization processes of the hippocam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9b83da84f19ca61e2a77103efbe30e
https://pub.dzne.de/record/138074
https://pub.dzne.de/record/138074
Autor:
Nicola Specchio, Pasquale Striano, Federico Zara, Federico Vigevano, Carlo Minetti, Maria Luisa Lispi, Laura Bordo
Publikováno v:
Epilepsia. 47:218-220
Summary: Benign familial infantile seizures (BFIS) is a clinical entity characterized by focal seizures with or without secondary generalization, occurring mostly in clusters, and usually first seen between 4 and 8 months of life. Psychomotor develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05f952d2d0cee3561118ad517e740ba
https://doi.org/10.1111/j.1528-1167.2006.00392.x
https://doi.org/10.1111/j.1528-1167.2006.00392.x
Autor:
Holger Lerche, Martin Pofahl, Stephan Theiss, Camille Liautard, Yuanyuan Liu, Johannes Slotta, Ulrike B. S. Hedrich, Andrew Escayg, Jennifer Lavigne, Heinz Beck, Massimo Mantegazza, Marcel Dihné, Daniel Kirschenbaum
Publikováno v:
The journal of neuroscience 34(45), 14874-14889 (2014). doi:10.1523/JNEUROSCI.0721-14.2014
Mutations inSCN1Aand other ion channel genes can cause different epileptic phenotypes, but the precise mechanisms underlying the development of hyperexcitable networks are largely unknown. Here, we present a multisystem analysis of anSCN1Amouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc8901192a48f0f5e7d5e96533da9d3
Autor:
Grzegorz M. Wilczynski, Elodie Chabrol, Katarzyna Łukasiuk, Naiara Vazquez, Elizabeth M. Powell, Matthew C. Walker, Asla Pitkänen, Xavier Ekolle Ndode-Ekane, Alexander Dityatev, Stefanie Dedeurwaerdere
Publikováno v:
Amsterdam [u.a.] : Elsevier, Progress in Brain Research 214, 229-262 (2014). doi:10.1016/B978-0-444-63486-3.00011-6
Brain Extracellular Matrix in Health and Disease / Pitkänen, Asla ; : Elsevier, 2014, ; ISSN: 00796123 ; ISBN: 9780444634863 ; doi:10.1016/B978-0-444-63486-3.00011-6
Brain Extracellular Matrix in Health and Disease / Pitkänen, Asla ; : Elsevier, 2014, ; ISSN: 00796123 ; ISBN: 9780444634863 ; doi:10.1016/B978-0-444-63486-3.00011-6
Currently, there are about 20 antiepileptic drugs on market. Still, seizures in about 30% of patients with epilepsy are not adequately controlled, or the drugs cause quality-of-life-compromising adverse events. Importantly, there are no treatments to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030aab596b2a1032db806460fb3fcf58
https://pub.dzne.de/record/144612
https://pub.dzne.de/record/144612
Autor:
Heinz Beck, Rainer Surges, Tallie Z. Baram, Christiane Rüschenschmidt, Maria Kukley, Johannes Schramm, Amy L. Brewster, Dirk Dietrich
Publikováno v:
Biochemical and biophysical research communications 420(1), 156-160 (2012). doi:10.1016/j.bbrc.2012.02.133
The hyperpolarization-activated cation current I(h) is an important regulator of neuronal excitability and may contribute to the properties of the dentate gyrus granule (DGG) cells, which constitute the input site of the canonical hippocampal circuit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235582b660f7b7fe80edda9d385d57d9
https://pub.dzne.de/record/136508
https://pub.dzne.de/record/136508