Zobrazeno 1 - 10
of 183
pro vyhledávání: '"metabolism, DNA"'
Autor:
Tariq Afroz, Elodie Chevalier, Mickael Audrain, Christopher Dumayne, Tamar Ziehm, Roger Moser, Anne-Laure Egesipe, Lorène Mottier, Monisha Ratnam, Manuela Neumann, Daniel Havas, Romain Ollier, Kasia Piorkowska, Mayank Chauhan, Alberto B. Silva, Samjhana Thapa, Jan Stöhr, Andrej Bavdek, Valerie Eligert, Oskar Adolfsson, Peter T. Nelson, Sílvia Porta, Virginia M.-Y. Lee, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina
Publikováno v:
Neurobiology of disease 179, 106050 (2023). doi:10.1016/j.nbd.2023.106050
Effective therapies are urgently needed to safely target TDP-43 pathology as it is closely associated with the onset and development of devastating diseases such as frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) and amyotrophic la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400aed6218e85601e1b0c35d97da9875
Publikováno v:
Neurobiology of disease 180, 106070 (2023). doi:10.1016/j.nbd.2023.106070
It is not clear to which degree limbic TDP-43 pathology associates with a cholinergic deficit in the absence of Alzheimer's disease (AD) pathology.Replicate and extend recent evidence on cholinergic basal forebrain atrophy in limbic TDP-43 and evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fbd10f02da6acaf2c47193b516e867
https://pub.dzne.de/record/257341
https://pub.dzne.de/record/257341
Autor:
Isabell Cordts, Annika Wachinger, Carlo Scialo, Paul Lingor, Magdalini Polymenidou, Emanuele Buratti, Emily Feneberg
Publikováno v:
Cells 12(4), 597 (2023). doi:10.3390/cells12040597
TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age-related TDP-43 encephalopathy, which clinically resembles Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18376730e6610a3fb08b9f24b993990
https://mediatum.ub.tum.de/doc/1704629/document.pdf
https://mediatum.ub.tum.de/doc/1704629/document.pdf
Autor:
Lisa Streit, Timo Kuhn, Thomas Vomhof, Verena Bopp, Albert C. Ludolph, Jochen H. Weishaupt, J. Christof M. Gebhardt, Jens Michaelis, Karin M. Danzer
Publikováno v:
Nature Communications 13(1), 5480 (2022). doi:10.1038/s41467-022-32939-0
TAR DNA binding protein 43 (TDP-43) is closely related to the pathogenesis of amyotrophic lateral sclerosis (ALS) and translocates to stress granules (SGs). The role of SGs as aggregation-promoting “crucibles” for TDP-43, however, is still under
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9652
International journal of molecular sciences 23(17), 9652 (2022). doi:10.3390/ijms23179652 special issue: "Neurological Diseases: A Molecular Genetic Perspective"
International journal of molecular sciences 23(17), 9652 (2022). doi:10.3390/ijms23179652 special issue: "Neurological Diseases: A Molecular Genetic Perspective"
Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease marked by death of motor neurons (MNs) present in the spinal cord, brain stem and motor cortex. Despite extensive research, the reason for neurodegeneration is s
Autor:
Henrick Riemenschneider, Qiang Guo, Jakob Bader, Frédéric Frottin, Daniel Farny, Gernot Kleinberger, Christian Haass, Matthias Mann, F. Ulrich Hartl, Wolfgang Baumeister, Mark S Hipp, Felix Meissner, Rubén Fernández‐Busnadiego, Dieter Edbauer
Publikováno v:
Embo Reports, 23(6):e53890. Wiley
EMBO reports 23(6), e53890 (2022). doi:10.15252/embr.202153890
EMBO Reports
EMBO Reports, 2022, 23, ⟨10.15252/embr.202153890⟩
EMBO reports 23(6), e53890 (2022). doi:10.15252/embr.202153890
EMBO Reports
EMBO Reports, 2022, 23, ⟨10.15252/embr.202153890⟩
International audience; Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and correlates with neurodegeneration in both diseases. In disease, characteris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f47f8b65554198f2de3cc8266a570e
https://research.rug.nl/en/publications/0af60e3e-49be-447c-9742-e5a5283a2b78
https://research.rug.nl/en/publications/0af60e3e-49be-447c-9742-e5a5283a2b78
Autor:
Jennie Olofsson, Peter Lönnerberg, Caroline Ingre, Elena Rodriguez-Vieitez, Inci Sevval Aksoylu, Caroline Mijnsbergen, Manuela Lehmann, Jan H. Veldink, Inti von Gohren Antequera, Albert C. Ludolph, Anna Szczepińska, Stefan Wouters, Mathias Uhlén, Ulf Kläppe, Eleonora Aronica, Hermieneke Vergunst-Bosch, Anna Månberg, Julia Remnestål, Sebastian A. Lewandowski, Lwaki Ebarasi, Peter Nilsson, Aylin Domaniku, Robert A. Harris, Nathan G. Skene, Jasper J. Anink, Joke De Vocht, Eva Hedlund, Annemarie Hübers, Koen Poesen, Philip Van Damme, Marta Trusohamn, Jonathan D. Gilthorpe, Maxim De Schaepdryver, Folkert Sanders
Publikováno v:
Nature medicine, 27(4), 640-646. Nature Publishing Group
Nat Med
Nature medicine 27(4), 640-646 (2021). doi:10.1038/s41591-021-01295-9
Nat Med
Nature medicine 27(4), 640-646 (2021). doi:10.1038/s41591-021-01295-9
Apart from well-defined factors in neuronal cells1, only a few reports consider that the variability of sporadic amyotrophic lateral sclerosis (ALS) progression can depend on less-defined contributions from glia2,3 and blood vessels4. In this study w
Autor:
Evelien Van Schoor, Simona Ospitalieri, Sebastiaan Moonen, Sandra O. Tomé, Alicja Ronisz, Orkun Ok, Jochen Weishaupt, Albert C. Ludolph, Philip Van Damme, Ludo Van Den Bosch, Dietmar Rudolf Thal
Publikováno v:
Acta neuropathologica 144(3), 393-411 (2022). doi:10.1007/s00401-022-02466-9
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in the motor cortex, brainstem, and spinal cord. Although ALS is considered a motor neuron disorder, neuroinflammation also plays an important role. Recent evid
Autor:
Francesca Paron, Petra Frick, Emanuele Buratti, Manuela Neumann, Jonas Kosten, Ian R. A. Mackenzie
Publikováno v:
Acta neuropathologica 140(5), 645-658 (2020). doi:10.1007/s00401-020-02207-w
Acta Neuropathologica
Acta Neuropathol
Acta Neuropathologica
Acta Neuropathol
Aggregation of hyperphosphorylated TDP-43 is the hallmark pathological feature of the most common molecular form of frontotemporal lobar degeneration (FTLD–TDP) and in the vast majority of cases with amyotrophic lateral sclerosis (ALS–TDP). Howev
Autor:
Jean-Marc Gallo, Dieter Edbauer
Publikováno v:
Science / Science now 378(6615), 28-29 (2022). doi:10.1126/science.ade4210
Science
Science
Frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS) are associated with both a repeat expansion in the C9orf72 gene and mutations in the TANK-binding kinase 1 (TBK1) gene. We found that TBK1 is phosphorylated in response to C9orf72 po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63e08f3103aef61de857a05ac4e632c