Zobrazeno 1 - 10
of 43
pro vyhledávání: '"metabolism, Cytokines"'
Autor:
Tomasz Próchnicki, Matilde B. Vasconcelos, Kim S. Robinson, Matthew S. J. Mangan, Dennis De Graaf, Kateryna Shkarina, Marta Lovotti, Lena Standke, Romina Kaiser, Rainer Stahl, Fraser G. Duthie, Maximilian Rothe, Kateryna Antonova, Lea-Marie Jenster, Zhi Heng Lau, Sarah Rösing, Nora Mirza, Clarissa Gottschild, Dagmar Wachten, Claudia Günther, Thomas A. Kufer, Florian I. Schmidt, Franklin L. Zhong, Eicke Latz
Publikováno v:
Nature immunology 24(4), 595-603 (2023). doi:10.1038/s41590-023-01451-y
Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D (GSDMD)-dependent cell death and maturation and release of IL-1β and IL-18. The triggers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951cef744dde927be85ce561d1cb4398
Autor:
Kairbaan Hodivala-Dilke, Melania Capasso, Frances R. Balkwill, Hemant M. Kocher, Michele Bombardieri, Sarah Spear, Francesca R. Delvecchio, Andrew Clear, Rachel Elizabeth Ann Fincham, Marina Roy-Luzarraga, John G. Gribben
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology 12(5), 1543-1565 (2021). doi:10.1016/j.jcmgh.2021.06.023
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1543-1565 (2021)
Cellular and Molecular Gastroenterology and Hepatology 12(5), 1543-1565 (2021). doi:10.1016/j.jcmgh.2021.06.023
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1543-1565 (2021)
Background and aims The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy. Yet, the precise role in PDAC has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbca100680dfb1efb8c0cbafa14981d0
http://europepmc.org/articles/PMC8529396
http://europepmc.org/articles/PMC8529396
Autor:
Marvin Oldrati, Daria Messelodi, Ivana Nikić-Spiegel, Maria-Jose Perez, Cong Yu, Aleksandra Arsić, Thomas Gasser, David C. Schöndorf, Vasiliki Panagiotakopoulou, Dina Ivanyuk, Meike Jakobi, Ruggiero Pio Cassatella, Silvia De Cicco, Michela Deleidi, Wadood Haq, Nicole Schneiderhan-Marra
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications 11(1), 5163 (2020). doi:10.1038/s41467-020-18755-4
Nature Communications
Nature Communications 11(1), 5163 (2020). doi:10.1038/s41467-020-18755-4
Parkinson’s disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ac34786697a3cff0d6b047aa772ef7
http://link.springer.com/article/10.1038/s41467-020-18755-4
http://link.springer.com/article/10.1038/s41467-020-18755-4
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific reports 10(1), 5941 (2020). doi:10.1038/s41598-020-62756-8
Scientific Reports
Scientific reports 10(1), 5941 (2020). doi:10.1038/s41598-020-62756-8
Neuroinflammation is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS), but only limited data are available on systematic peripheral and central immune cell profiles in ALS. We studied detailed immune profiles of 73 ALS patients and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::17d4e379d69aa11a70d673164b59f121
http://link.springer.com/article/10.1038/s41598-020-62756-8
http://link.springer.com/article/10.1038/s41598-020-62756-8
Autor:
Anil Akbal, Alesja Dernst, Marta Lovotti, Matthew S. J. Mangan, Róisín M. McManus, Eicke Latz
Publikováno v:
Cellular & molecular immunology 19(11), 1201-1214 (2022). doi:10.1038/s41423-022-00922-w
Cellular and Molecular Immunology
Cellular and Molecular Immunology
NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon detection of an activating stimulus, NLRP3 transitions from an inactive homo-oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce1c4f5416b34b342207670b67960e6
https://pub.dzne.de/record/165241
https://pub.dzne.de/record/165241
Autor:
Bart Everts, Leonard R. Pelgrom, Joost M. Lambooij, Isabel Stoetzel, Maria Embgenbroich, Joachim L. Schultze, Vanessa van Harmelen, Jonas Schulte-Schrepping, Hendrik J. P. van der Zande, Hanno Pijl, Kristian Händler, Lisa R. Hoving, Laura Schlautmann, Karin de Ruiter, Sven Burgdorf, Anna Zawistowska-Deniziak, Leonie Hussaarts, Ko Willems van Dijk, Bruno Guigas, Maria Yazdanbakhsh, Marjolein A. Wijngaarden, Noemí García-Tardón
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 118(31), e2103304118 (2021). doi:10.1073/pnas.2103304118
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences, 118(31). NATL ACAD SCIENCES
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences, 118(31). NATL ACAD SCIENCES
Proinflammatory activation of macrophages in metabolic tissues is critically important in the induction of obesity-induced metaflammation. Here, we demonstrate that the soluble mannose receptor (sMR) plays a direct functional role in both macrophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4853dd491738c9d4b4c81a0e54327c
https://hdl.handle.net/1887/3214620
https://hdl.handle.net/1887/3214620
Autor:
Holger Jon Møller, Claudia Schulte, Daniela Berg, Daniel E. Otzen, Kalpana Shrivastava, Sara K. Nissen, Walter Maetzler, David Goldeck, Marina Romero-Ramos
Publikováno v:
Nissen, S K, Shrivastava, K, Schulte, C, Otzen, D E, Goldeck, D, Berg, D, Møller, H J, Maetzler, W & Romero-Ramos, M 2019, ' Alterations in Blood Monocyte Functions in Parkinson's Disease ', Movement Disorders, vol. 34, no. 11, pp. 1711-1721 . https://doi.org/10.1002/mds.27815
Movement disorders 34(11), 1711-1721 (2019). doi:10.1002/mds.27815
Movement disorders 34(11), 1711-1721 (2019). doi:10.1002/mds.27815
BACKGROUND: PD is a multisystem disease where both central and peripheral nervous systems are affected. This systemic involvement also includes the immune response in PD, which implicates not only microglia in the brain, but also peripheral immune ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3472c893711e71c8276085e8e54ed7
https://doi.org/10.1002/mds.27815
https://doi.org/10.1002/mds.27815
Autor:
Linker, Ralf A., Haase, Stefanie, Mäurer, Jonas, Duscha, Alexander, Lee, De-Hyung, Balogh, Andras, Gold, Ralf, Müller, Dominik N., Haghikia, Aiden
Publikováno v:
Frontiers in Immunology
Frontiers in immunology 12, 701626 (2021). doi:10.3389/fimmu.2021.701626
Frontiers in immunology 12, 701626 (2021). doi:10.3389/fimmu.2021.701626
High-fat diets (HFD) are linked to obesity and associated comorbidities and induce pathogenic T helper (Th) 17 cells while decreasing regulatory T cells (Treg). This pro-inflammatory environment also aggravates immunopathology in experimental autoimm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90fbddd7246d55093ed5a91778f609d
http://europepmc.org/articles/PMC8204048
http://europepmc.org/articles/PMC8204048
Autor:
Nobuaki Yoshida, Manabu Ozawa, Ryota Sato, Kaiwen Liu, Ryosuke Hiranuma, Tatjana Reuter, Takeshi Ichinohe, Yun Zhang, Eicke Latz, Takuma Shibata, Kensuke Miyake, Ryutaro Fukui
Publikováno v:
International immunology 33(9), 479-490 (2021). doi:10.1093/intimm/dxab033
RNase T2, a ubiquitously expressed RNase, degrades RNAs in the endosomal compartments. RNA sensors, double-stranded RNA (dsRNA)-sensing Toll-like receptor 3 (TLR3) and single-stranded RNA (ssRNA)-sensing TLR7, are localized in the endosomal compartme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343a33df2873e4eae0910a7724b7494b
https://pub.dzne.de/record/162817
https://pub.dzne.de/record/162817
Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia
Autor:
Jibrin Danladi, Hemmen Sabir
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 707, p 707 (2021)
International journal of molecular sciences 22(2), 707-(2021). doi:10.3390/ijms22020707
International Journal of Molecular Sciences
International journal of molecular sciences 22(2), 707-(2021). doi:10.3390/ijms22020707
International Journal of Molecular Sciences
Neonatal encephalopathy (NE) is a global burden, as more than 90% of NE occurs in low- and middle-income countries (LMICs). Perinatal infection seems to limit the neuroprotective efficacy of therapeutic hypothermia. Efforts made to use therapeutic hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee4ef8871ccc264fbaad639997533b0
https://www.mdpi.com/1422-0067/22/2/707
https://www.mdpi.com/1422-0067/22/2/707