LncRNA RUS shapes the gene expression program towards neurogenesis

Autor: Marius F Schneider, Veronika Müller, Stephan A Müller, Stefan F Lichtenthaler, Peter B Becker, Johanna C Scheuermann

Publikováno v: Life science alliance 5(10), e202201504 (2022). doi:10.26508/lsa.202201504

The evolution of brain complexity correlates with an increased expression of long, non- coding (lnc) RNAs in neural tissues. Although prominent examples illustrate the potential of lncRNAs to scaffold and target epigenetic regulators to chromatin loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b963c0a1cbc534a97beac63d22ee2c
https://doi.org/10.1101/2022.02.17.480853

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

Autor: Mathieu Blanchette, Albert M. Berghuis, Hiromichi Suzuki, Pratiti Bandopadhayay, Dong Anh Khuong-Quang, Dylan M. Marchione, Nicolas De Jay, Wajih Jawhar, Angelia V. Bassenden, Djihad Hadjadj, Ashot S. Harutyunyan, Shriya Deshmukh, Steffen Albrecht, Michele Zeinieh, Nikoleta Juretic, Paolo Salomoni, Katerina Vanova, Ales Vicha, Stefan M. Pfister, Manav Pathania, Selin Jessa, Almos Klekner, Leonie G. Mikael, CM Kramm, David T.W. Jones, Tenzin Gayden, Sebastian Brandner, Michal Zapotocky, Nicola Maestro, Eleanor Woodward, Alexander G. Weil, David S. Ziegler, Jordan R. Hansford, Steven Hébert, Frank Dubois, Benjamin Ellezam, Deli A, Damien Faury, Véronique Lisi, Augusto Faria Andrade, Andrey Korshunov, Mariella G. Filbin, Michael D. Taylor, Claudia L. Kleinman, Andrea Bajic, Carol C.L. Chen, Caterina Russo, Nada Jabado, Peter Hauser, Benjamin A. Garcia, Stephen C. Mack, Keith L. Ligon, David Sumerauer, Lenka Krskova, Jason Karamchandani, Rameen Beroukhim, Rola Dali, László Bognár, Dominik Sturm, József Virga, Marie Coutelier, Livia Garzia, Paul G Ekert, Josef Zamecnik

Publikováno v: Cell 183(6), 1617-1633.e22 (2020). doi:10.1016/j.cell.2020.11.012
Cell

Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here, we show that 50% of G34R/V-tumours (n=95) b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a47ac89beefcaff088e65fd3f8a3589
https://doi.org/10.1016/j.cell.2020.11.012

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Autor: Gael Cagnone, Siddhant U. Jain, Warren A. Cheung, Jacek Majewski, Simon Papillon-Cavanagh, Shriya Deshmukh, Hamid Nikbakht, Jad I. Belle, Haifen Chen, Damien Faury, Benjamin Ellezam, Peter W. Lewis, Carol C.L. Chen, Nicolas De Jay, Abdulshakour Mohammadnia, Bo Hu, Melissa K. McConechy, Brian Krug, Dylan M. Marchione, Claudia L. Kleinman, Michele Zeinieh, Chao Lu, Ashot S. Harutyunyan, Tomi Pastinen, Leonie G. Mikael, Benjamin A. Garcia, Manav Pathania, Alexander G. Weil, Nada Jabado, Rui Li, Alexandre Montpetit, Denise Bechet, Paolo Salomoni

Publikováno v: Nature Communications
Nature Communications 10(1), 1262 (2019). doi:10.1038/s41467-019-09140-x
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to assess H3K27M effects in vitro and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8009a4766e296bb95581ac15a67e41
https://pubmed.ncbi.nlm.nih.gov/30890717

Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants

Autor: Stanimir Dulev, Christelle de Renty, Alexander V. Strunnikov, Etienne Schwob, Rajvi Mehta, Ivan Minkov

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2009, 106 (34), pp.14466--71. ⟨10.1073/pnas.0900190106⟩

The CDC14 family of multifunctional evolutionarily conserved phosphatases includes major regulators of mitosis in eukaryotes and of DNA damage response in humans. The CDC14 function is also crucial for accurate chromosome segregation, which is exempl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a486436b1b47cc3ed1971fa298efc52
https://doi.org/10.1073/pnas.0900190106

Inhibition of Histone Deacetylases Alters Allelic Chromatin Conformation at the Imprinted U2af1-rs1 Locus in Mouse Embryonic Stem Cells

Autor: Sanjeev Khosla, Tamzin E. Randall, Bryan M. Turner, Robert Feil, Laura P. O'Neill, Cécile Fournier, Richard I. Gregory

Publikováno v: J Biol Chem
J Biol Chem, 2002, 277 (14), pp.11728--34. ⟨10.1074/jbc.M105775200 M105775200 [pii]⟩
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2002, 277 (14), pp.11728--34. ⟨10.1074/jbc.M105775200⟩

International audience; Most loci that are regulated by genomic imprinting have differentially methylated regions (DMRs). Previously, we showed that the DMRs of the mouse Snrpn and U2af1-rs1 genes have paternal allele-specific patterns of acetylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d779eb0c42ccd938df65fad892b2bb78
https://doi.org/10.1074/jbc.m105775200