Zobrazeno 1 - 10
of 74
pro vyhledávání: '"metabolism, Cell Membrane"'
Autor:
Stefan Becker, Garima Jaipuria, Andrei Leonov, Markus Zweckstetter, Karin Giller, Gwladys Rivière, Loren B. Andreas
Publikováno v:
European Biophysics Journal
European biophysics journal 50(2), 173-180 (2021). doi:10.1007/s00249-020-01487-0
European biophysics journal 50(2), 173-180 (2021). doi:10.1007/s00249-020-01487-0
Translocator Protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein commonly used as a biomarker for neuroinflammation and is also a potential therapeutic target in neurodegenerative diseases. Despite intensive research efforts, the functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697dd7dca7bbd460c9897a605089f415
https://doi.org/10.1007/s00249-020-01487-0
https://doi.org/10.1007/s00249-020-01487-0
Autor:
Markus Zweckstetter, King Faisal Yambire, Niels Denkert, Claudia Steinem, Nelli Teske, Daryna Tarasenko, Michael Meinecke, Ira Milosevic, Indrani Mukherjee, Garima Jaipuria, Benjamin Kroppen
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and molecular life sciences 78(5), 2355-2370 (2021). doi:10.1007/s00018-020-03647-z
Cellular and molecular life sciences 78(5), 2355-2370 (2021). doi:10.1007/s00018-020-03647-z
Membrane remodeling is a critical process for many membrane trafficking events, including clathrin-mediated endocytosis. Several molecular mechanisms for protein-induced membrane curvature have been described in some detail. Contrary, the effect that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299604b0231580d1487db82e8f61580b
https://doi.org/10.1007/s00018-020-03647-z
https://doi.org/10.1007/s00018-020-03647-z
Autor:
Zohreh Hosseinzadeh, Stefanie Schuster, Yogesh Singh, Nefeli Zacharopoulou, Philip Höflinger, Ludger Schöls, Christos Stournaras, Florian Lang, Lisann Pelzl, Yamini Sharma, Stefan Hauser, Eberhart Zrenner, Daniel Rathbun
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific reports 10(1), 8391 (2020). doi:10.1038/s41598-020-64845-0
Scientific reports 10(1), 8391 (2020). doi:10.1038/s41598-020-64845-0
Loss of function mutations of the chorein-encoding gene VPS13A lead to chorea-acanthocytosis (ChAc), a neurodegenerative disorder with accelerated suicidal neuronal cell death, which could be reversed by lithium. Chorein upregulates the serum and glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78376c4b2009a2cf3944bfb257b95e7
http://link.springer.com/article/10.1038/s41598-020-64845-0
http://link.springer.com/article/10.1038/s41598-020-64845-0
Autor:
Dieter Langosch, Hannes Heinel, Christina Scharnagl, Claudia Muhle-Goll, Harald Steiner, Philipp Högel, Simon Menig, Daniel Huster, Alexander Götz, Nadine Mylonas, Frits Kamp, Burkhard Luy, Alexander Vogel, Mara Silber, Hannes Feyrer
Publikováno v:
Biophys J
Biophysical journal 116(11), 2103-2120 (2019). doi:10.1016/j.bpj.2019.04.030
Biophysical journal 116(11), 2103-2120 (2019). doi:10.1016/j.bpj.2019.04.030
Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is implicated in Alzheimer’s disease pathogenesis. Biophysical data have suggested that the N-terminal part of the C99 transmembrane domain (TMD) is separated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43179bc7d9a088e925fbc9d25ec19287
https://doi.org/10.1016/j.bpj.2019.04.030
https://doi.org/10.1016/j.bpj.2019.04.030
Autor:
Simone Bonelli, Veronica M. Pravata, Stefan F. Lichtenthaler, Elisa Monaca, Matteo Calligaris, Danilo D'Apolito, Stephan A. Müller, Anna Paola Carreca, Simone D. Scilabra
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2392, p 2392 (2021)
International journal of molecular sciences 22(5), 2392-(2021). doi:10.3390/ijms22052392
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2392, p 2392 (2021)
International journal of molecular sciences 22(5), 2392-(2021). doi:10.3390/ijms22052392
Ectodomain shedding is a key mechanism of several biological processes, including cell-communication. Disintegrin and metalloproteinases (ADAMs), together with the membrane-type matrix metalloproteinases, play a pivotal role in shedding transmembrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0958eee5746a91257cb3317225c20c2e
http://europepmc.org/articles/PMC7957584
http://europepmc.org/articles/PMC7957584
Autor:
Stefan F. Lichtenthaler, Paul Saftig, Tobias B. Huber, Lukas Heintz, Lisa Seipold, Lisa Schebsdat, Maja T. Lindenmeyer, Renate Lüllmann-Rauch, Sebastian Wetzel, Stephanie Zielinski, Oliver Kretz, Catherine Meyer-Schwesinger, Marlies Sachs, Wiebke Sachs, Julia Reichelt, Thorsten Wiech, Stephan A. Müller
Publikováno v:
Journal of the American Society of Nephrology 32(6), 1389-1408 (2021). doi:10.1681/ASN.2020081213
J Am Soc Nephrol
J Am Soc Nephrol
Background Podocytes embrace the glomerular capillaries with foot processes, which are interconnected by a specialized adherens junction to ultimately form the filtration barrier. Altered adhesion and loss are common features of podocyte injury, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd38702448fa14059c39567c6bc8975
Autor:
Stefan F. Lichtenthaler, Edgar Meinl
Publikováno v:
Journal of Biological Chemistry
JBC papers in press 295(35), 12353-12354 (2020). doi:10.1074/jbc.H120.015304
JBC papers in press 295(35), 12353-12354 (2020). doi:10.1074/jbc.H120.015304
Sheddases are specialized proteases that control the abundance and function of membrane proteins by cleaving their substrate's extracellular domain (ectodomain), a process known as shedding. Hundreds of shedding substrates have been identified, but l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3dca9e631fb0ce2957b6ce371d1eb9
https://pubmed.ncbi.nlm.nih.gov/32580944
https://pubmed.ncbi.nlm.nih.gov/32580944
Autor:
Johannes H. Hegemann, Katja Mölleken, Agathe Subtil, Stephan F. Lichtenthaler, Sebastian Hänsch, Gido Murra, Karl Köhrer, Ana Rita Furtado, Bastian Dislich, Dominik Spona
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, pp.201911528. ⟨10.1073/pnas.1911528117⟩
Proceedings of the National Academy of Sciences of the United States of America 117(5), 2634-2644 (2020). doi:10.1073/pnas.1911528117
Hänsch, Sebastian; Spona, Dominik; Murra, Gido; Köhrer, Karl; Subtil, Agathe; Furtado, Ana Rita; Lichtenthaler, Stephan F; Dislich, Bastian; Mölleken, Katja; Hegemann, Johannes H (2020). Chlamydia-induced curvature of the host-cell plasma membrane is required for infection. Proceedings of the National Academy of Sciences of the United States of America-PNAS, 117(5), pp. 2634-2644. National Academy of Sciences NAS 10.1073/pnas.1911528117
Proceedings of the National Academy of Sciences of the United States of America, 2020, pp.201911528. ⟨10.1073/pnas.1911528117⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, pp.201911528. ⟨10.1073/pnas.1911528117⟩
Proceedings of the National Academy of Sciences of the United States of America 117(5), 2634-2644 (2020). doi:10.1073/pnas.1911528117
Hänsch, Sebastian; Spona, Dominik; Murra, Gido; Köhrer, Karl; Subtil, Agathe; Furtado, Ana Rita; Lichtenthaler, Stephan F; Dislich, Bastian; Mölleken, Katja; Hegemann, Johannes H (2020). Chlamydia-induced curvature of the host-cell plasma membrane is required for infection. Proceedings of the National Academy of Sciences of the United States of America-PNAS, 117(5), pp. 2634-2644. National Academy of Sciences NAS 10.1073/pnas.1911528117
Proceedings of the National Academy of Sciences of the United States of America, 2020, pp.201911528. ⟨10.1073/pnas.1911528117⟩
Significance We describe a mechanism by which the obligate intracellular pathogen Chlamydia pneumoniae induces curvature of the host-cell plasma membrane and recruits a central component of the endocytotic machinery. We demonstrate that a type III-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da794f542df00b89d096d6498efa34ea
https://hal-pasteur.archives-ouvertes.fr/pasteur-02453968/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-02453968/document
Publikováno v:
The EMBO journal 39(20), e104247 (2020). doi:10.15252/embj.2019104247
The EMBO Journal
The EMBO Journal
Sequence variants of the microglial expressed TREM2 (triggering receptor expressed on myeloid cells 2) are a major risk factor for late onset Alzheimer's disease. TREM2 requires a stable interaction with DAP12 in the membrane to initiate signaling, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336001d0982d8a4fa0349c4e2f1ac011
Autor:
Rico J. E. Derks, Frederick Campbell, Edgar Dawkins, Edith Winkler, Li Kong, Frits Kamp, Harald Steiner, Alexander Kros, Martin Giera
Publikováno v:
Biochimica et biophysica acta / Biomembranes 1862(5), 183200 (2020). doi:10.1016/j.bbamem.2020.183200
BBA-Biomembranes, 1862(5). ELSEVIER
BBA-Biomembranes, 1862(5). ELSEVIER
The biophysical properties and biological functions of membranes are highly dependent on lipid composition. Supplementing cellular membranes with very long chain fatty acids (vlcFAs) is notoriously difficult given the extreme insolubility of vlcFAs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f208449ec0237cdb31de1110e65e9f5c