Zobrazeno 1 - 10 of 18 pro vyhledávání: '"metabolism, Calcium Channels"'
1
Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons
Autor: Lisa Henkel, Karen Grütz, Anne Grünewald, Anna Kutschenko, Johanne Heine, Selma Staege, Andreas Hermann, Philip Seibler, Hannes Glaß, Norman Kalmbach, Florian Wegner, Thomas Gschwendtberger
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3565, p 3565 (2021)
International journal of molecular sciences 22(7), 3565 (2021). doi:10.3390/ijms22073565
Myoclonus-dystonia (DYT-SGCE, formerly DYT11) is characterized by alcohol-sensitive, myoclonic-like appearance of fast dystonic movements. It is caused by mutations in the SGCE gene encoding ε-sarcoglycan leading to a dysfunction of this transmembra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efd60b20c5aaaf2112bf11ccfefbe65
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2
Enhanced hippocampal type II theta activity AND altered theta architecture in mice lacking the Cav3.2 T-type voltage-gated calcium channel
Autor: Marco Weiergräber, Muhammad Imran Arshaad, Johanna Daubner, Dan Ehninger, Agapios Sachinidis, Karl Broich, Anna Papazoglou, Magdalena Elisabeth Siwek, Christina Henseler, Jürgen Hescheler
Publikováno v: Scientific reports, 11:1099
Scientific reports 11(1), 1099 (2021). doi:10.1038/s41598-020-79763-4
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
T-type Ca2+ channels are assumed to contribute to hippocampal theta oscillations. We used implantable video-EEG radiotelemetry and qPCR to unravel the role of Cav3.2 Ca2+ channels in hippocampal theta genesis. Frequency analysis of spontaneous long-t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72c3edb6ad5a22aa5142666a2c7af8b
https://repository.publisso.de/resource/frl:6429794
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3
Association of A Novel Splice Site Mutation in P/Q-Type Calcium Channels with Childhood Epilepsy and Late-Onset Slowly Progressive Non-Episodic Cerebellar Ataxia
Autor: Marina Dusl, Thomas Klopstock, Silvia Belia, Manuela Wiessner, Peter Bauer, Jan Senderek, Claudia Stendel, Marta Cenciarini, Ehsan Nematian-Ardestani, Mauro Pessia, Maria Cristina D'Adamo
Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 11
International journal of molecular sciences 21(11), 3810-(2020). doi:10.3390/ijms21113810
International Journal of Molecular Sciences, Vol 21, Iss 3810, p 3810 (2020)
Episodic ataxia type 2 (EA2) is characterized by paroxysmal attacks of ataxia with typical onset in childhood or early adolescence. The disease is associated with mutations in the voltage-gated calcium channel alpha 1A subunit (Cav2.1) that is encode
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4
Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses
Autor: Christine E Gee, Jessica Mitlöhner, Alexander Dityatev, Hartmut Niekisch, Renato Frischknecht, Max F. K. Happel, Constanze I. Seidenbecher, Rahul Kaushik, Eckart D. Gundelfinger, Armand Blondiaux
Publikováno v: Cells
Cells 9(2), 260 (2020). doi:10.3390/cells9020260
Cells, 9(2):260
Cells, Vol 9, Iss 2, p 260 (2020)
Volume 9
Issue 2
In the brain, Hebbian-type and homeostatic forms of plasticity are affected by neuromodulators like dopamine (DA). Modifications of the perisynaptic extracellular matrix (ECM), which control the functions and mobility of synaptic receptors as well as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705f575a9b5cc35954059eb0cd2dc7f4
https://pubmed.ncbi.nlm.nih.gov/31972963
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5
Cav3.2 T-Type Calcium Channels Are Physiologically Mandatory for the Auditory System
Autor: Anna Papazoglou, Maheshwar Bakki, Christina Henseler, Ralf Müller, Muhammad Imran Arshaad, Robin Seidel, Julien Soos, Jürgen Hescheler, Marco Weiergräber, Carola Wormuth, Agapios Sachinidis, Andreas Lundt, Dan Ehninger, Karl Broich
Publikováno v: Neuroscience 409, 81-100 (2019). doi:10.1016/j.neuroscience.2019.04.024
Voltage-gated Ca2+ channels (VGCCs) play key roles in auditory perception and information processing within the inner ear and brainstem. Pharmacological inhibition of low voltage-activated (LVA) T-type Ca2+ channels is related to both age- and noise
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6
The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS
Autor: Joachim L. Schultze, Sebastian Dupraz, Claudia J. Laskowski, Frank Bradke, Thomas Ulas, Andrea Tedeschi, Jia Xue, Marc Beyer
Publikováno v: Neuron 92(2), 419-434 (2016). doi:10.1016/j.neuron.2016.09.026
Injuries to the adult CNS often result in permanent disabilities because neurons lose the ability to regenerate their axon during development. Here, whole transcriptome sequencing and bioinformatics analysis followed by gain- and loss-of-function exp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588aa45b1ade85064676346ec2572ec7
https://doi.org/10.1016/j.neuron.2016.09.026
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7
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses
Autor: Dietmar Schmitz, Rosenmund T, Gülçin Vardar, Claudia G Willmes, Alexander Stumpf, Marta Maglione, Alexander M. Walter, Marisa M Brockmann, Benjamin R. Rost, Haucke, Stephan J. Sigrist, Suneel Reddy-Alla, Christian Rosenmund, Thorsten Trimbuch, Britta J. Eickholt, Maria Pangalos, Grauel Mk
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 113(41): 11615–11620
Proceedings of the National Academy of Sciences of the United States of America 113(41), 11615-11620 (2016). doi:10.1073/pnas.1605256113
Significance Highly regulated and precise positioning of Ca 2+ channels at the active zone (AZ) controls Ca 2+ nanodomains at release sites. Their exact localization affects vesicular release probability (P VR ) and is important for proper synaptic t
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https://doi.org/10.1073/pnas.1605256113
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8
Reply to Rutter et al.: The roles of cytosolic and intramitochondrial Ca2+ and the mitochondrial Ca2+-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation
Autor: Michael Schwarzer, Volkmar Lessmann, Wolfram S. Kunz, Torsten Doenst, Marten Szibor, Frank N. Gellerich, Stefan Vielhaber, Zemfira Gizatullina
Publikováno v: J Biol Chem
JBC papers in press 295(30), 10507-10507 (2020). doi:10.1074/jbc.RL120.014342
Each model used in the work referred to by Rutter et al. (1) addressed certain aspects of mitochondrial biology, and together, they fully support the conclusions made. Please note that we describe Ca2+-mediated regulation of oxidative phosphorylation
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https://doi.org/10.1074/jbc.rl120.014342
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9
Coexpressed Auxiliary Subunits Exhibit Distinct Modulatory Profiles on AMPA Receptor Function
Autor: Alexandru Rusu, Ling Zhang, Jakob von Engelhardt, Paul Farrow, Anton Schulmann, Konstantin Khodosevich, Eric Jacobi, Rolf Sprengel, Hannah Monyer
Publikováno v: Neuron 83(3), 601-615 (2014). doi:10.1016/j.neuron.2014.07.004
Neuron
Summary Gating properties and surface trafficking of AMPA receptors (AMPARs) are modulated by auxiliary subunits. Here we studied the function of coexpressed auxiliary subunits belonging to two different classes. We focused on TARP γ-8 and CKAMP44 i
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10
Heparin/heparan sulfates bind to and modulate neuronal L-type (Cav1.2) voltage-dependent Ca(2+) channels
Autor: Alexander Dityatev, Martin Heine, Gianpiero Garau, Paola Magotti, Patricia Marie-Jeanne Lievens, Svetlana Korotchenko, Vladimir Berezin
Publikováno v: Experimental neurology 274(Pt B), 156-165 (2015). doi:10.1016/j.expneurol.2015.08.006
Experimental Neurology
Our previous studies revealed that L-type voltage-dependent Ca(2+) channels (Cav1.2 L-VDCCs) are modulated by the neural extracellular matrix backbone, polyanionic glycan hyaluronic acid. Here we used isothermal titration calorimetry and screened a s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605dc340222484e49e4f0b0d7e211581
https://pubmed.ncbi.nlm.nih.gov/26272754
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