Zobrazeno 1 - 10
of 155
pro vyhledávání: '"metabolism, Calcium"'
Autor:
Lucia Cottone, Lorena Ligammari, Hang-Mao Lee, Helen J. Knowles, Stephen Henderson, Sara Bianco, Christopher Davies, Sandra Strauss, Fernanda Amary, Ana Paula Leite, Roberto Tirabosco, Kristian Haendler, Joachim L. Schultze, Javier Herrero, Paul O’Donnell, Agamemnon E. Grigoriadis, Paolo Salomoni, Adrienne M. Flanagan
Publikováno v:
Cell death and differentiation 29(12), 2459-2471 (2022). doi:10.1038/s41418-022-01031-x
Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3.3 as the sole genetic driver present in bone-forming osteoprogenitor ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060d9f2f6a2fa9b3ca4257b925d5abd3
https://doi.org/10.1038/s41418-022-01031-x
https://doi.org/10.1038/s41418-022-01031-x
Autor:
Inseon Song, Tatiana Kuznetsova, David Baidoe-Ansah, Hadi Mirzapourdelavar, Oleg Senkov, Hussam Hayani, Andrey Mironov, Rahul Kaushik, Michael Druzin, Staffan Johansson, Alexander Dityatev
Publikováno v:
Cells
Volume 12
Issue 5
Pages: 744
Cells 12(5), 744 (2023). doi:10.3390/cells12050744 special issue: "10th Anniversary of Cells—Advances in Cell Microenvironment"
Volume 12
Issue 5
Pages: 744
Cells 12(5), 744 (2023). doi:10.3390/cells12050744 special issue: "10th Anniversary of Cells—Advances in Cell Microenvironment"
Our previous studies demonstrated that enzymatic removal of highly sulfated heparan sulfates with heparinase 1 impaired axonal excitability and reduced expression of ankyrin G at the axon initial segments in the CA1 region of the hippocampus ex vivo,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc2816ce2156f93870810f5feb846ef
Autor:
Ricardo Castro-Hernández, Tea Berulava, Maria Metelova, Robert Epple, Tonatiuh Peña Centeno, Julia Richter, Lalit Kaurani, Ranjit Pradhan, M. Sadman Sakib, Susanne Burkhardt, Momchil Ninov, Katherine E. Bohnsack, Markus T. Bohnsack, Ivana Delalle, Andre Fischer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 120(9), e2204933120 (2023). doi:10.1073/pnas.2204933120
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
N 6 -methyladenosine (m 6 A) regulates mRNA metabolism. While it has been implicated in the development of the mammalian brain and in cognition, the role of m 6 A in synaptic plasticity, especially during cognitive decline, is not fully understood. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c930e6d735bc673ed9753105dea4b90
https://pub.dzne.de/record/255495
https://pub.dzne.de/record/255495
Publikováno v:
Trends in neurosciences 46(1), 32-44 (2023). doi:10.1016/j.tins.2022.10.012
The heterogeneity of the endoplasmic reticulum (ER) makes it a versatile platform for a broad range of homeostatic processes, ranging from calcium regulation to synthesis and trafficking of proteins and lipids. It is not surprising that neurons use t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b746ce885448ea25c9ad93807a0bd672
https://pubmed.ncbi.nlm.nih.gov/36428191
https://pubmed.ncbi.nlm.nih.gov/36428191
Autor:
Eva Haas, Olaf Riess, Athar H. Chishti, Yacine Maringer, Stefan Hauser, Jonasz J. Weber, Jeannette Hübener-Schmid, Nicolas Casadei
Publikováno v:
Hum Mol Genet
Human molecular genetics 29(6), 892-906 (2020). doi:10.1093/hmg/ddaa010
Human molecular genetics 29(6), 892-906 (2020). doi:10.1093/hmg/ddaa010
Proteolytic fragmentation of polyglutamine-expanded ataxin-3 is a concomitant and modifier of the molecular pathogenesis of Machado–Joseph disease (MJD), the most common autosomal dominant cerebellar ataxia. Calpains, a group of calcium-dependent c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9bc3418f7a9675f288b55130bf1c68a
https://doi.org/10.1093/hmg/ddaa010
https://doi.org/10.1093/hmg/ddaa010
Autor:
Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading, Francesco Roselli
Publikováno v:
Journal of neuroinflammation 19(1), 279 (2022). doi:10.1186/s12974-022-02634-4
Background Traumatic brain injury (TBI) is characterized by massive changes in neuronal excitation, from acute excitotoxicity to chronic hyper- or hypoexcitability. Nuclear calcium signaling pathways are involved in translating changes in synaptic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b41486da2df8fa0d3e78a6c6472942
https://pub.dzne.de/record/165539
https://pub.dzne.de/record/165539
Autor:
Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, Kristian Händler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Publikováno v:
Molecular metabolism 61, 101503 (2022). doi:10.1016/j.molmet.2022.101503
Molecular Metabolism
Molecular Metabolism
Molecular metabolism 61, 101503 (2022). doi:10.1016/j.molmet.2022.101503
Published by Elsevier, Oxford [u.a.]
Published by Elsevier, Oxford [u.a.]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b24ae904790eb54c273e4cca8c9a0d
https://pub.dzne.de/record/164042
https://pub.dzne.de/record/164042
Autor:
Julia Cha, M. Sadman Sakib, Elisabeth M. Zeisberg, Gregor Eichele, Jiayin Zhou, Ranjit Pradhan, A. Francis Stewart, Dennis M. Krüger, Rezaul Islam, Andrea Kranz, Tonatiuh Pena Centeno, Parth Devesh Joshi, Xingbo Xu, Sophie Schröder, Cemil Kerimoglu, Lalit Kaurani, Andre Fischer, Alexandra Michurina
Publikováno v:
The EMBO Journal
The EMBO journal 41(1), e106459 (2022). doi:10.15252/embj.2020106459
The EMBO journal 41(1), e106459 (2022). doi:10.15252/embj.2020106459
In mammals, histone 3 lysine 4 methylation (H3K4me) is mediated by six different lysine methyltransferases. Among these enzymes, SETD1B (SET domain containing 1b) has been linked to syndromic intellectual disability in human subjects, but its role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef1344308a941bd4b7ecfec8bbbc773
http://europepmc.org/articles/PMC8724770
http://europepmc.org/articles/PMC8724770
Autor:
Nefeli Zacharopoulou, Christos Stournaras, Bhuyan Aam, Itishri Sahu, Zohreh Hosseinzadeh, Ludger Schöls, Basma Sukkar, Florian Lang, Tamer Al-Maghout, Lisann Pelzl, Stefan Hauser
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 1, Pp 278-289 (2018)
Cellular physiology and biochemistry 51(1), 278-289 (2018). doi:10.1159/000495229
Cellular physiology and biochemistry 51(1), 278-289 (2018). doi:10.1159/000495229
Background/Aims: The neurodegenerative disease Chorea-Acanthocytosis (ChAc) is caused by loss-of-function-mutations of the chorein-encoding gene VPS13A. In ChAc neurons transcript levels and protein abundance of Ca2+ release activated channel moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065a98c934df070a5ce682a783fb6020
https://www.karger.com/Article/FullText/495229
https://www.karger.com/Article/FullText/495229
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3767-3774.e3 (2019)
Cell reports 29(12), 3767-3774.e3 (2019). doi:10.1016/j.celrep.2019.11.060
Cell reports 29(12), 3767-3774.e3 (2019). doi:10.1016/j.celrep.2019.11.060
Summary: At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone. In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3c34b5845e28d806fbd1f5fe5c25f9
http://www.sciencedirect.com/science/article/pii/S2211124719315517
http://www.sciencedirect.com/science/article/pii/S2211124719315517